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2003, Number 1

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Rev Hosp M Gea Glz 2003; 6 (1)

Pathophysiological aspects in uremic syndrome

Gutiérrez VI, Domínguez MA, Acevedo MJJ

Language: Spanish
References: 62
Page: 13-24
PDF size: 130.75 Kb.


ABSTRACT

The uremic syndrome can be defined as a deterioration of biochemical and physiologic functions during development of end-stage renal disease. Clinical signs and symptoms are al least in part due to the accumulation of uremic retention solutes and uremic toxins. Arginina is one of the most versatiles amino-acids in animal cells as a precursor for the synthesis no only of proteins but also of nitric oxide, urea, glutamate, polyamines and creatine, therefore, and overview of arginina metabolism is important for a better understanding of uremic syndrome. This article review pathophysiological aspects of uremic toxins and mechanisms of accumulation that include a decrease in renal function, oxidative stress, inflammatory response, uremia per se and modifications of proteins resulting in abnormalities of biological functions in patiens with chronic renal failure.


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