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ISSN 0188-9796 (Print)

2002, Number 3

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Rev Endocrinol Nutr 2002; 10 (3)

Endocrine and paracrine influence on the adipogenesis

Viveros CA, Laviada MH, Bastarrachea SR

Language: Spanish
References: 106
Page: 151-164
PDF size: 121.72 Kb.


ABSTRACT

Current scientific information on the mechanisms of adipocyte development was reviewed. In vitro and in vivo studies (different mesodermal stem cell lines with adipogenic potential) were quantified to assess the influence of the most representative substances with hormonal (Insuline, insuline-like growth factor, glucocorticoids, triiodothyronine and cAMP) and parahormonal (GFs and TNFa) activity on both the adipocyte differentiation and the changes on recruitment/proliferative pattern in the mature cell. The results of this quest showed that there were more inductor agents (66.7%) than inhibitors (33.3%) to produce adipocyte differentiation. PPARg2 was the most active transcriptional factor involved in promoting adipogenesis and TNFa to inhibit this effect. Trough the logic analysis of these molecular interactions it can be obtained the biochemical and physiological basis for the pharmacologic designing of antiobesity compounds that may act on specifics cellular structures linked with adipogenesis; additionally, the clinicians will be able to enlarge their knowledge on the obesity pathophysiology and on the pharmacodynamics of the new drugs used for treating adipose mass excess.


REFERENCES

  1. Villee AC. Biología: Algunos conceptos generales importantes en biología y principios, y teorías de la evolución. 7ª. Ed. Editorial Interamericana, México. 1986: 14-15 y 630-645.

  2. Albert B, Bray D, Lewis J, Raff M, Robert K, Watson DJ. Evolution of the cell: Molecular biology of the cell. 3rd Ed. New York & London. 1994: 3-41.

  3. Dyson DR. Cell biology: a molecular approach. 1st. Ed. Boston USA. Allyn and Bacon, INC. 1974: 2-58, 62-94, 148-182.

  4. Lehninger LA. Bioquímica: las bases moleculares de la estructura y función celular. 2ª Ed. Omega S.A. Barcelona, España. 1995: 846.

  5. Friedman JM, Leibel RL. Tackling a weighty problem. Cell 1992; 69: 217-20.

  6. Junqueira CL, Carneiro J. Histología básica, texto y atlas. 4ª Ed. Masson, Barcelona, España. 1996: 103-109.

  7. Junqueira CL, Carneiro J. Biología celular y molecular: transformación y almacenamiento de energía. 6ª Ed. McGraw-Hill International, Chile. 1998: 68-82.

  8. Moore LK, Persuad NTV. Embriología básica. 5ª Ed. Interamericana, MacGraw-Hill México. 1995: 102.

  9. Arner P. The b3 adrenergic receptor a cause and a cure of obesity. N Engl J Med 1995: 333-382.

  10. Clemente K et al. Genetic variation in b3 adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995: 333- 352.

  11. Katzung GB. Farmacología básica y clínica: Introducción a la farmacología autonómica. 7ª Ed. Manual Moderno, México. 1999: 91-109.

  12. Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM et al. Expression of ob gene in adipose cells. J Biol Chem 1996; 271: 2365-68.

  13. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.

  14. Hwang CS, Mandrup S, MacDougald OM, Geiman DE, Lane MD. Transcriptional activation of the mouse obese gene by CCAAT/enhancer protein. Proc Natl Acad Sci USA 1996; 93: 873-77.

  15. Cornelius P, MacDougald OA, Lane MD. Regulation of adipocyte development. Annu Rev Nutr 1994; 14: 99-129.

  16. Kirkland J, Hollenberg C, Gillon W. Age. Anatomic site. And the replication and differentiation of adipocyte precursors. Am J Physiol 1990; 258: C206-10.

  17. MacDougald OA, Lane MD. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 1995; 64: 345-73.

  18. Novikoff AB, Novikoff PM, Rosen OM. Rubin CS. Organelle relationships in cultured 3T3-L1 preadipocytes. J Cell Biol 1980; 87: 180-96.

  19. Freytag SO, Paielli DL, Gilbert JD. Ectopic expression of the CCAAT/enhancerbinding protein a promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev 1994; 8: 1654-63.

  20. Serrero G, Lepak NM, Goodrich SP. Prostaglandin F2a inhibits the differentiation of adipocyte precursors in primary culture. Biochem Biophys Res Commun 1992; 183: 438-42.

  21. Shillabeer G, LI Z-H, Hatch G, Kumar V, Lau DCW. A novel method for studying preadipocyte differentiation in vitro. Int J Obesity 1996; 20: 577-83.

  22. Lau DCW, Shillabeer G, Wong K-L, Tough SC, Russell JC. Influence of paracrine factors on preadipocyte replication and differentiation. Int J Obesity 1990; 14: 193-201.

  23. Varzaneh FE, Shillabeer G, Wong K-L, Lau DCW. Extracellular matrix components secreted by microvascular endothelial cells stimulate preadipocyte differentiation in vitro. Metabolism 1994; 43: 906-12.

  24. Lau DCW, Roncari DAK, Hollenberg CH. Release of mitogenic factors by cultured preadipocytes from a massively obese human subjects. J Clin Invest 1987; 79: 632-36.

  25. Mandrup SM, Lane MD. Regulating adipogenesis. J Biol Chem 1997; 272: 5367-70.

  26. Green H, Kehinde O. Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line. J Cell Phys 1979; 101: 169-72.

  27. Mandrup S, Loftus TM, MacDougald CA, Kuhadja F, Lane MD. Obese gene expression at in vivo levels by fat pads derived from subcutaneously implanted 3T3-F442A preadipocytes. Proc Natl Acad Sci USA 1997; 93: 4300-5.

  28. Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Phystol Rev 1979; 59:,719-809.

  29. Student AK, Hsu RY, Lane MD. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J Biol Chem 1980; 255: 4745-50.

  30. Amri E-Z, Dani C, Doglio A, Etienne J, Gnmaldi P, Ailhaud G. Adipose cell differentiation: evidence for a two-step process in the polyamine-dependent. Ob/1754 clonal line. Brochem 1986; 238: 115-22.

  31. Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS. Insulin-like growth factor is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem 1988; 263: 9402-8.

  32. Reed BC, Lane MD. Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 1980; 77: 285-89.

  33. Knight DM, Chapman AB, Navre M, Drinkwater L, Bruno JJ, Ringold GM. Requirements for triggering of adipocyte differentiation by glucocorticoids and indomethacin. Mol Endocrinol 1987; 1: 36-43.

  34. Aihaud G. Extracellular factors signaling pathways and differentiation of adipose precursor cells. Curr Opin Cell Biol 1990; 2: 1043-19.

  35. Luetteke N, Lee D, Palmiter R, Brinster R, Sandgren E. Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells. Cell Growth Diff 1993; 4: 203-13.

  36. Serrero G. EGF inhibits the differentiation of adipocyte precursors in primary cultures. Biochem Biophys Res Commun 1987; 146: 194-202.

  37. Serrero G, Mills D. Physiological role of epidermal growth factor on adipose tissue development in vivo. Proc Natl Acad Sci USA 1991; 8: 3912-16.

  38. Navre M, Ringold G. Differential effects of fibroblast growth factor and tumor promoters on the initiation and maintenance of adipocyte differentiation. J Cell Biol 1989; 109: 1857-63.

  39. Pairault J, Green H. A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate as differentiation marker. Proc Nalt Acad Sci USA 1979; 76: 5138-42.

  40. Darimont C, Gaillard D, Ailhaud G, Negrel R. Terminal differentiation of mouse preadipocyte cells: adipogenic and antimitogenic role of triodothyronine. Mol Cell Endocrinol 1993; 98: 67-73.

  41. Xue JC, Schwartz EJ, Chawla A, Lazar MA. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPAR. Mol Cell Biol 1996; 16: 1567-75.

  42. Bain G, Ray WJ, Yao M, Goalieb DT. Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture. Biochem Biophys Res Commun 1996; 223: 691-94.

  43. Stone RL, Bernlohr DA. The molecular basis for inhibition of adipose conversion of murine 3T3-L1 cells by retinoic acid. Differentiation 1990; 45: 119-27.

  44. Safonova, Darimont C, Amri E-Z, Grimaldi P, Ailhaud G et al. Retinoids are positive effectors of adipose cell differentiation. Mol Cell Endocrinol 1994; 104: 201-11.

  45. Oka A, Miki T, Mauro Y, Yamasaki M, Ariyoshi T, Fujii H. Effects of vitamin A on the quality of Japanese bovine marbling. Clin Vet Med 1992; 10: 34-40.

  46. Cook K, Min H, Johnson D, Chaplinsky R, Flier J et al. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science 1987; 237: 402-5.

  47. Cianflone K, Maslowska M. Differentiation-induced production of ASP in human adipocytes. Eur J Clin Invest 1995; 25: 817-25

  48. Cianflone K, Roncari DA, Maslowska M, Baldo A, Forden J, Sniderman AD. Adipsin/acylation stimulating protein system in human adipocytes: regulation of triacylglycerol synthesis. Biochemistry 1994; 33: 9489-95.

  49. Frederich RJ, Kahn BB, Peach MJ, Flier JS. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 1992; 19: 339-44.

  50. Zorad S, Fickova M, Zelezna B, Macho L, Kral JG. The role of angiotensin II and its receptors in regulation of adipose tissue metabolism and cellularity. Gen Physiol Biophys 1995; 14: 383-91.

  51. Jonsson JR, Game PA, Head RJ, Frewin DB. The expression and localization of the angiotensin-converting enzyme m RNA in human adipose tissue. Blood Press 1994; 3: 72-75.

  52. Torlone E, Britta M, Rambotti AM, Perriello G, Santeusanio F et al. Improved insulin action and glycemic control after long-term angiotensin-converting enzyme inhibition in subjects with arterial hypertension and type II diabetes. Diabetes Care 1993; 16: 1347-55.

  53. Darimont C, Vassaux G, Ailhaud G, Negrel R. Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotesin-II. Endocrinology 1994; 135: 2030-36.

  54. Richelsen B. Release and effects of prostaglandins in adipose tissue. Prost Leuk E 1992; 47: 171-82.

  55. Hyman BT, Stoll LL, Spector AA. Prostaglandin production by 3T3-L1 cells in culture. Biochim Biophys Acta 1982; 713: 375-85.

  56. Casimir DA, Miller CW, Ntambi JM. Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. Differentiation 1996; 60: 203-10.

  57. Miller CW, Casimir DA, Ntambi JM. The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2 ALPHA. Endocrinology 1996; 137: 5641-50.

  58. Negrel R, Grimaldi P, Atlhaud G. Establishment of readipocyte clonal line from epididymal fat pad of oblob mouse that responds to insulin and to lipolytic hormones. Proc Natl Acad Sci USA 1978; 75: 6054-58.

  59. Hertz R, Berman I, Keppler D, Bar TJ. Activation of gene transcription by prostacyclin analogues is mediated by the peroxisomeproliferators activated receptor (PPAR). Eur J Biochem 1996; 235: 42-47.

  60. Forman BM, Tontonoz P, Chen J, Brun RP, Spregelman BM, Evans RM. 15-Deoxy-delta 12.14 prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995; 83: 803-12.

  61. Weiner FR, Smith PJ, Wertheimer S, Rubin CS. Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem 1991; 266: 23525-28.

  62. Ron D, Brasier AR, McGehee RJ, Habener JF. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhacer binding protein (C/EBP). J Clin Invest 1992; 89: 223-33.

  63. Hotamisligil G, Arner P, Caro J, Atkinson R, Spiegelman B. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-15.

  64. Hurst H. Transcription factors I: bZ1P proteins. Protein Profile 1994; 1: 123.

  65. Yeh WC, Cao Z, Classon M, McKnight SL. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 1995; 9(2): 168-81.

  66. Descombes P, Schibler U. A liver enriched transcriptional activator protein. LAP. And a transcriptional inhibitory protein. LIP. Are translated from the same Mrna. Cell 1991; 67: 569-79.

  67. Wu Z, Bucher NL, Farmer SR. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPb, C/EBPd and glucocorticoids. Mol Cell Biol 1996; 16: 4128-36.

  68. Lin F-T, Lane MD. Antisense CCA-AT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes Dev 1992; 6: 533-44.

  69. Wang N, Finegold M, Bradley A, Ou C, Abdelsayed S et al. Impaired energy homeostasis in C/EBP alpha knockout mice. Science 1995; 269: 1108-12.

  70. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J 1996; 15: 1012-20.

  71. Lin F-T, Lane MD. CCAAT/enhancer binding protein is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA 1994; 91: 8757-61.

  72. Vasseur-Cognet M, Lane MD. CCA-AT/enhancer binding protein a (c/EBPa) undifferentiated protein: a developmentally regulated nuclear protein that binds to the C/EBP(gene promoter. Proc Natl Acad Sci USA 1993; 90: 312-16.

  73. Umek RM, Friedman AD, McKnight SL. CAAT-enhancer binding protein: a component of a differentiation switch. Science 1991; 251: 288-92.

  74. Freytag SO, Geddes TJ. Reciprocal regulation of adipogenesis by myc and C/EBP. Science 1992; 256: 379-82.

  75. Constance C, Morgan J, Umek R. C/EBP alpha regulation of the growth-arrest-associated gene gadd45. Mol Cell Biol 1996; 16: 3878-33.

  76. Timchenko N, Wilde M, Nakanishi M, Smith J, Darlington G. CCAAT/enhancer binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-I/SDI-1) protein. Genes Dev 1996; 10: 804-15.

  77. Ubeda M, Wang X-Z, Zinszzner H, Wu I, Habener, Ron D. Stress-induce binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol 1996; 16: 1479-89.

  78. Batchvarova N, Wang XZ, Ron D. Inhibition of adipogenesis by the stress-induced protein CHOP(Gadd153). EMBO 1995; 14: 4654-61.

  79. Carlson SG, Fawcett TW, Bartlett JD, Bernier M, Holbrook NJ. Regulation of the C/EBP related gene gadd153 by glucose deprivation. Mol Cell Biol 1993; 13: 4736-44.

  80. Wang X, Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP(GADD153) by p38 MAP kinase. Science 1996; 272: 1347-49.

  81. Chawla A, Schwarz EJ, Dimaculangan EE, Lazar MA. Peroxisome proliferator activated receptor (PPAR)y: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinol 1994; 135: 798-800.

  82. Teboul L, Gaillard D, Staccini L, Inadera H, Amn E-Z, Grimaldi PA. Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. J Biol Chem 1995; 270: 28183-87.

  83. Brun RP, Tontonoz P, Forman BM, Ellis R, Jasmine C et al. Differential activation of adipogensis by multiple PPAR isoforms. Genes Dev 1996; 10: 974-84.

  84. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 1995; 83: 841-50 .

  85. Tontonoz P, Hu E, Graves RA, Budavari Al, Spiegelman BM. m PPARg2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 8: 1224-34.

  86. Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996; 1302: 93-109.

  87. Tontonoz P, Hu E, Graves RA, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56.

  88. Miller CW, Ntambi JM. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci USA 1996; 93: 9443-48.

  89. Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D et al. Structural organization of mouse peroxisome proliferator-activated receptor gamma (m PPAR gamma) gene alternative promoter use and different splicing yield two m PPAR gamma isoforms. Proc Natl Acad Sci USA 1995; 92: 7921-25.

  90. Tontonoz P, Nagy L. Regulation of macrophage gene expression by peroxisone-proliferator-activated receptor (gamma): implications for cardiovascular disease. Current Opinion in Lipidology 1999; 10 (6): 485-90.

  91. Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP et al. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 1995; 270: 23975-83.

  92. Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin(ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1996; 93: 5793-96.

  93. Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR( and C/EBP). Proc Nail Acad Sci USA 1995; 92: 9856-60.

  94. Shalev A, Siegnst-Kaiser CA, Yen PM, Wahli W, Burger AGC et al. The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology 1996; 137: 4499-502.

  95. Hu E, Kim J, Sarraf P, Spiegelman B. Inhibition of adipogenesis through MAP Kinase-mediated phosphorylation of PPAR gamma. Science 1996; 274: 2100-3.

  96. Zhang B, Berger J, Zhou G, Elbrecht Z, Biswas S et al. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem 1996; 271: 31771-74.

  97. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix–loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol 1993; 13: 4753-59.

  98. Yokayama C, Wang X, Briggs MR, Admon A, Wu J et al. SREBP-1. A basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 1993; 75: 187-97.

  99. Kim JB, Spotts GD, Halvorsen Y-D, Shih H-M, Ellenberger T et al. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol 1995; 15: 2582-88.

  100. Kim JB, Spiegelman BM. ADDI/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 1996; 10: 1096-107.

  101. Kawabe Y, Sato R, Matsumoto A, Honda M, Wada Y et al. Regulation of fatty acid synthase expression by cholesterol in human cultured cells. Biochem Biophys Res Common 1996; 219: 515-20.

  102. Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages. One within a transmembrane segment. Cell 1996; 85: 1037-46.

  103. Kawada T, Kamei Y, Sugimoto E. The possibility of active form of vitamins A and D as suppressors on adipocyte development via ligand-dependent transcriptional regulators. Int J Obesity 1996; 20: 552-57.

  104. Schwarz EJ, Reginato MJ, Shao D, Krakow SL, Lazar MA. Retinoic acid blocks adipogenesis by inhibiting C/EBP mediated transcription. Mol Cell Biol 1997; 17: 1552-61.

  105. Wu Z, Xie Y, Bucher NL, Farmer SR. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev 1995; 9: 2350-63.

  106. Christy RJ, Yang VW, Ntembi jm, Geirnan DE, Landschulz WH et al. Differentiation induced gene expression in 3t3-l.1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev 1989; 3: 1323-35.




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