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2021, Number 4

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Rev Latin Infect Pediatr 2021; 34 (4)

Rothia mucilaginosa bacteremia in immunocompromised children: case report and review of the literature

Castillo BJI, Pérez CS, Cisneros SD, Larragoity GEA, Espinosa VF, Rodríguez SMM, Romo LE, De PAG, Vaquera ADN, Mascareñas SAH

Language: Spanish
References: 33
Page: 193-202
PDF size: 285.82 Kb.


ABSTRACT

Rothia mucilaginosa, previously known as Stomatococcus mucilaginosus, is a Gram-positive coccobacillus that is part of the microbiota of the oral cavity, and upper respiratory tract. Infections with this microorganism are infrequent, occurring mainly in immunocompromised children. It is currently recognized as an opportunistic pathogen and emerging in children with cystic fibrosis. In the present work, we describe two cases of pediatric oncology patients with primary R. mucilaginosa bacteremia, and a literature review of R. mucilaginosa bacteremia in immunocompromised children.


REFERENCES

  1. Collins MD, Hutson RA, Baverud V, Falsen E. Characterization of a Rothia-like organism from a mouse: description of Rothia nasimurium sp. nov. and reclassification of Stomatococcus mucilaginosus as Rothia mucilaginosa comb. nov. Int J Syst Evol Microbiol. 2000; 50 Pt 3: 1247-1251.

  2. Poyer F, Friesenbichler W, Hutter C, Pichler H, Dworzak M, Peters C et al. Rothia mucilaginosa bacteremia: A 10-year experience of a pediatric tertiary care cancer center. Pediatr Blood Cancer. 2019; 66 (7): e27691.

  3. Silva FO. Rothia mucilaginosa. retrato microbiológico. Rev Chil Infect. 2008; 25 (1): 29.

  4. Trivedi MN, Malhotra P. Rothia prosthetic knee joint infection. J Microbiol Immunol Infect. 2015; 48 (4): 453-455.

  5. Wang JY, Brossard J, Cellot S, Dix D, Feusner J, Johnston DL et al. Invasive Rothia infections in children with acute myeloid leukemia: a report from the Canadian infections in AML research group. Pediatr Hematol Oncol. 2016; 33 (5): 277-281.

  6. Mikulska M, Viscoli C. Gram-positive bacterial infections after haematopoietic stem cell or solid organ transplantation. In: Ljungman P, Snydman D, Boeckh M (eds). Transplant infections. Cham: Springer; 2016. Available in: https://doi.org/10.1007/978-3-319-28797-3_20

  7. Rubin SJ, Lyons RW, Murcia AJ. Endocarditis associated with cardiac catheterization due to a Gram-positive coccus designated Micrococcus mucilaginosus incertae sedis. J Clin Microbiol. 1978; 7 (6): 546-549.

  8. Treviño M, García-Zabarte A, Quintás A, Varela E, López-Paz JM, Jato A et al. Stomatococcus mucilaginosus septicemia in a patient with acute lymphoblastic leukaemia. Eur J Clin Microbiol Infect Dis. 1998; 17 (7): 505-507.

  9. Chavan RS, Pannaraj PS, Luna RA, Szabo S, Adesina A, Versalovic J et al. Significant morbidity and mortality attributable to Rothia mucilaginosa infections in children with hematological malignancies or following hematopoietic stem cell transplantation. Pediatr Hematol Oncol. 2013; 30 (5): 445-454.

  10. Ochi F, Tauchi H, Moritani K, Yonezawa S, Miyamoto H, Suemori K et al. Rothia mucilaginosa infection in a child with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017; 64 (1): 205-206.

  11. Gutierrez V, Cerda C, Alcantara A, Clavarie X. Rothia mucilaginosa, an important cause of invasive disease in children with leukemia: report of 2 cases and review of the literature. Authorea [Internet]. 2020. Available in: https://www.authorea.com/doi/full/10.22541/au.159284826.61673369

  12. Park MK, Khan J, Stock F, Lucey DR. Successful treatment of Stomatococcus mucilaginosus meningitis with intravenous vancomycin and intravenous ceftriaxone. Clin Infect Dis. 1997; 24 (2): 278.

  13. Bayhan C, Karadag Oncel E, Cengiz AB, Oksuz AB, Aydin GB. Bacteriemia causada por Rothia mucilaginosa después de neumonía en un paciente con trasplante de células progenitoras hematopoyéticas. Arch Argent Pediatr. 2016; 114 (5): 343-345.

  14. Khan ST, Ahamed M, Musarrat J, Al-Khedhairy AA. Anti-biofilm and antibacterial activities of zinc oxide nanoparticles against the oral opportunistic pathogens Rothia dentocariosa and Rothia mucilaginosa. Eur J Oral Sci. 2014; 122 (6): 397-403.

  15. Henwick S, Koehler M, Patrick CC. Complications of bacteremia due to Stomatococcus mucilaginosus in neutropenic children. Clin Infect Dis. 1993; 17 (4): 667-671.

  16. Morgan EA, Henrich TJ, Jarell AD, Shieh WJ, Zaki SR, Marty FM et al. Infectious granulomatous dermatitis associated with Rothia mucilaginosa bacteremia: a case report. Am J Dermatopathol. 2010; 32 (2): 175-179.

  17. Clinical and Laboratory Standards Institute (CLSI). Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria. CLSI guideline M45. 3rd edition. Wayne, Pennsylvania: CLSI; 2015.

  18. McWhinney PH, Kibbler CC, Gillespie SH, Patel S, Morrison D, Hoffbrand AV et al. Stomatococcus mucilaginosus: an emerging pathogen in neutropenic patients. Clin Infect Dis. 1992; 14 (3): 641-646.

  19. Bruminhent J, Tokarczyk MJ, Jungkind D, DeSimone JA Jr. Rothia mucilaginosa prosthetic device infections: a case of prosthetic valve endocarditis. J Clin Microbiol. 2013; 51 (5): 1629-1632.

  20. Ramos JM, Mateo I, Vidal I, Rosillo EM, Merino E, Portilla J. Infection due to Rothia mucilaginosa. A respiratory pathogen? Enferm Infecc Microbiol Clin. 2014; 32 (5): 306-309.

  21. Goldman M, Chaudhary UB, Greist A, Fausel CA. Central nervous system infections due to Stomatococcus mucilaginosus in immunocompromised hosts. Clin Infect Dis. 1998; 27 (5): 1241-1246.

  22. Weinblatt ME, Sahdev I, Berman M. Stomatococcus mucilaginosus infections in children with leukemia. Pediatr Infect Dis J. 1990; 9 (9): 678-679.

  23. Ascher DP, Zbick C, White C, Fischer GW. Infections due to Stomatococcus mucilaginosus: 10 cases and review. Rev Infect Dis. 1991; 13 (6): 1048-1052.

  24. Langbaum M, Eyal FG. Stomatococcus mucilaginosus septicemia and meningitis in a premature infant. Pediatr Infect Dis J. 1992; 11 (4): 334-335.

  25. Souillet G, Chomarat M, Barbé G, Balouck N, Ploton C, Philippe N. Stomatococcus mucilaginosus meningitis in a child with leukemia. Clin Infect Dis. 1992; 15 (6): 1045.

  26. Andstrom E, Bygdeman S, Ahlén S, Heimdal A, Nystrom B. Stomatococcus mucilaginosus septicemia in two bone marrow transplanted patients. Scand J Infect Dis. 1994; 26 (2): 209-214.

  27. Vaccher S, Cordiali R, Osimani P, Manso E, de Benedictis FM. Bacteremia caused by Rothia mucilaginosa in a patient with Shwachman-Diamond syndrome. Infection. 2007; 35 (3): 209-210.

  28. Mustafa MM, Carlson LR, Krisher K. Stomatococcus mucilaginosus fatal sepsis in a child with leukemia. Pediatr Infect Dis J. 1993; 12 (9): 784-786.

  29. Kaufhold A, Reinert RR, Kern W. Bacteremia caused by Stomatococcus mucilaginosus: report of seven cases and review of the literature. Infection. 1992; 20 (4): 213-220.

  30. Rizvi M, Fatima N, Shukla I, Afzal K. Stomatococcus mucilaginosus meningitis in a healthy 2-month-old child. J Med Microbiol. 2008; 57 (Pt 3): 382-383.

  31. Vydra J, Shanley RM, George I, Ustun C, Smith AR, Weisdorf DJ et al. Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2012; 55 (6): 764-770.

  32. Rosa RG, Dos Santos RP, Goldani LZ. Mortality related to coagulase-negative staphylococcal bacteremia in febrile neutropenia: A cohort study. Can J Infect Dis Med Microbiol. 2014; 25 (1): e14-e17.

  33. Ascher DP, Bash MC, Zbick C, White C. Stomatococcus mucilaginosus catheter-related infection in an adolescent with osteosarcoma. South Med J. 1991; 84 (3): 409-410.




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