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2021, Number 6

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Acta Pediatr Mex 2021; 42 (6)

Update on neonatal hemochromatosis

Sandoval-Garín, Nadia; Zárate-Mondragón FE

Language: Spanish
References: 28
Page: 294-304
PDF size: 225.92 Kb.


ABSTRACT

Liver failure in the neonatal period has a mortality of up to 24% and may have an infectious, metabolic, ischemic and neonatal hemochromatosis etiology. Neonatal hemochromatosis in up to 80-90% is of autoimmune origin and is known as gestational alloimmune liver disease, it is produced by the transplacental passage of IgG maternal immunoglobulins from week 12 of gestation directed against neonatal liver receptors; It causes severe liver damage accompanied by an iron deposit both in the liver and in other tissues such as the salivary or thyroid glands, with which the diagnosis is made either by biopsy or magnetic resonance imaging. Timely treatment reduces its mortality from 80% to 20% and is by administering gamma globulin at 1 mg/kg/do.


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