Lozano CO

Language: Spanish
References: 18
Page: 147-150
PDF size: 57.06 Kb.

ABSTRACT

Recently it has been demonstrated that the fatty fabric works as an endocrine organ able to secrete adipocytokines that participate in the regulation of the metabolism. Of particular importance they are the resisting and the adipocytokine for their role in the ethyology from the resistance to the insulin; the resisting is specifically a polypeptide secreted by the adipocytes that rises in the obesity. Its administration to mice diminishes the action of the insulin and it alters the tolerance to glucose. The adiponectin also secreted by the adipocytes diminishes in the obesity and in the diabetes type 2; it has been suggested that the hypoadiponectinemia is a primary genetic defect that contributes to the ethyology of obesity and the resistance to insulin.

REFERENCES

1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Baneryee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 1997; 409: 307-12.

2. Henry RR. Thiazolidinediones. Endocrinol Metab Clin North Am 1997; 26: 553-73.

3. Chawla A, Schwars EJ, Dimaculangan DD, Lazar MA. Peroxisome proliferator-activated receptor (gamma): Adipose predominant expression and induction early in adipocyte differentation. Endocrinology 1994; 135: 798-800.

4. Savage DB, Seweter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, O’Rahilly S. Resistin/FIZZ3 expression in relation to obesity and peroxisome proliferator-activated receptor gamma action in humans. Diabetes 2001; 50: 2199-02.

5. Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 2000; 46: 462-72.

6. Hotamisiligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor alfa: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.

7. Olei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-TNF alfa (CDP 571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 1996; 45: 881-85.

8. Mc Ternan PG, Mc Ternan CL, Chetty R, Jenner K, Fisher F, Lauer MN, Crocker J, Barnett AH, Kumar S. Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab 2002; 87: 2407-11.

9. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose-collagen like factor, apM1 (aipose most abundant gene transcript 1) Biochem. Biophys Res Commun 1996; 221: 286-89.

10. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocites. J Biol Chem 1995; 270: 26476-49.

11. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10967-73.

12. Nakano Y, Tobe I, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP 28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 1996; 120: 803-12.

13. Berg H, Combs TP, Xueligan D, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Med 2001; 7: 947-52.

14. Yamauchi T, Kadowaki T et al. The fat derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med 2001; 7: 947-52.

15. Arita Y, Kihara S, Ouchi N et al. Paradoxical decrease of an adipose specific protein, adiponectin in obesity. Biochem Biophys Res Comm 1999; 257: 79-83.

16. Hotta K, Funahashi T, Arita Y et al. Plama concentrations of a novel adipose-specific protein adiponectin in type 2 diabetic patients. Arterioescler Thromb Vasc Biol 2000; 20: 1595-99.

17. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzaua Y, Pratley RE, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930-35.

18. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A. A haplotype at the adiponectinlocus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002; 51: 2306-12.