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2002, Number 2

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Rev Fac Med UNAM 2002; 45 (2)

Intercellular communication has interested physiologists for many years. Even though for decades adenosin-trisphophate (ATP) has been exclusively considered a source of energy for intracellular metabolism, in reality, it has been accepted that ATP is an i

Mendoza FV, Pacheco DRL, Valenzuela F

Language: Spanish
References: 35
Page: 71-77
PDF size: 111.78 Kb.


ABSTRACT

Intercellular communication has interested physiologists for many years. Even though for decades adenosin-trisphophate (ATP) has been exclusively considered a source of energy for intracellular metabolism, in reality, it has been accepted that ATP is an important cellular neurotransmitter, as much intra –as extra-cellular. In recent years, the concept of purinergic neurotransmission has also been established that regulates, amongst other systems, coronary blood flow. In addition, the P1 and P2 receptors have been recognized, one trait of which is to intervene in blood platelet aggregation and another is to act as transmembranal controls, similar to the sodium and potassium channels of epithelial cells, but very different from glutamate and nicotine channels.
Independently of noradrenaline, ATP participates in synaptic communication between sympathetic nerves in the blood vessels, especially in certain areas such as the mesenteric plexus; purinergic transmission in the parasympathetic system is important in the activity of the heart and respiratory tracts. Finally, ATP facilities the activity of dopaminergic neurons and at the same time acts in pain transmission in the slow conduction sensory neurons.


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