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2021, Number 3

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Rev Educ Bioquimica 2021; 40 (3)

Un vistazo a la morfología y dinámica de la mitocondria y a los sitios de producción de las especies reactivas de oxígeno

Matus OG, Pardo JP, Guerra SG, Buendía CK, Matus OM, González J, Luqueño BOI, Vázquez CM, Romero AL

Language: Spanish
References: 69
Page: 111-127
PDF size: 847.49 Kb.


ABSTRACT

Mitochondria are cellular organelles, capable to adapt their metabolism through fission and fusion events, leading to elongated, interconnected, and fragmented morphologies. They have their own genome and are responsible for the synthesis of ATP, through oxidative phosphorylation. Mitochondria also generate reactive oxygen species (ROS) and this production occurs in the respiratory complexes and in some dehydrogenases located in the mitochondrial matrix. This review addresses the classic concepts and describes new insights into the function, morphology, and mitochondrial metabolism, such as the formation of mitochondrial networks, the cristae junction structure, the presence of respiratory supercomplexes, processes of fusion and fission and the sites of reactive oxygen production in mitochondria and by other enzymes.


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