2021, Number 3
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An Med Asoc Med Hosp ABC 2021; 66 (3)
Anesthesia and diabetes in the perioperative period
Ortega GJPA, Carrillo MNE, López RAY
Language: Spanish
References: 54
Page: 195-204
PDF size: 296.55 Kb.
ABSTRACT
Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia and disorders in the metabolism of carbohydrates, proteins and fats. It affects about 9.3% of the world population. In Mexico, up to 25% of surgical patients may be diabetic, being one of the leading causes of morbi and mortality, as well as an increase in the number of days of hospital stay. During intraoperative management, the main objective is to maintain adequate glucose levels, normal electrolyte concentration, as well as to guarantee optimal and adequate cardiovascular and renal function. It is the responsibility of the surgical team to have the necessary resources to diagnose and treat perioperative hyperglycemia, in order to reduce related complications. In cases of elective surgery, glycosylated hemoglobin levels ≤ 8.5% are recommended. The goal of this review is to know the pathophysiology of diabetes in the perioperative period in order to treat, improve and reduce all complications in time.
REFERENCES
Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002; 87 (3): 978-982.
Frisch A, Chandra P, Smiley D, Peng L, Rizzo M, Gatcliffe C et al. Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery. Diabetes Care. 2010; 33 (8): 1783-1788.
Kotagal M, Symons RG, Hirsch IB, Umpierrez GE, Dellinger EP, Farrokhi ET et al. Perioperative hyperglycemia and risk of adverse events among patients with and without diabetes. Ann Surg. 2015; 261 (1): 97-103.
Farrokhi F, Smiley D, Umpierrez GE. Glycemic control in non-diabetic critically ill patients. Best Pract Res Clin Endocrinol Metab. 2011; 25 (5): 813-824.
Furnary AP, Gao G, Grunkemeier GL, Wu Y, Zerr KJ, Bookin SO et al. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003; 125 (5): 1007-1021.
Umpierrez GE, Smiley D, Jacobs S, Peng L, Temponi A, Mulligan P et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011; 34 (2): 256-261.
Cook G, Gall I. Anaesthetic Management of the patients with diabetes. Anaesth Intensive Care Med. 2011; 12: 438.
Dimas AS, Lagou V, Barker A, Knowles JW, Magi R, Hivert MF et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 2014; 63 (6): 2158-2171.
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019; 157: 107843.
Clement S, Braithwaite SS, Magee MF, Ahmann A, Smith EP, Schafer RG et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care. 2004; 27 (2): 553-591.
Stacey RB, Vera T, Morgan TM, Jordan JH, Whitlock MC, Hall ME et al. Asymptomatic myocardial ischemia forecasts adverse events in cardiovascular magnetic resonance dobutamine stress testing of high-risk middle-aged and elderly individuals. J Cardiovasc Magn Reson. 2018; 20 (1): 75.
Halkos ME, Lattouf OM, Puskas JD, Kilgo P, Cooper WA, Morris CD et al. Elevated preoperative hemoglobin A1c level is associated with reduced long-term survival after coronary artery bypass surgery. Ann Thorac Surg. 2008; 86 (5): 1431-1437.
Karamanos E, Sivrikoz E, Beale E, Chan L, Inaba K, Demetriades D. Effect of diabetes on outcomes in patients undergoing emergent cholecystectomy for acute cholecystitis. World J Surg. 2013; 37 (10): 2257-2264.
Mongkolpun W, Provenzano B, Preiser JC. Updates in glycemic management in the hospital. Curr Diab Rep. 2019; 19 (11): 133.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010; 33 (Suppl 1): S62-S69.
Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002; 106 (16): 2067-2072.
Chan TM. The permissive effects of glucocorticoid on hepatic gluconeogenesis. Glucagon stimulation of glucose-suppressed gluconeogenesis and inhibition of 6-phosphofructo-1-kinase in hepatocytes from fasted rats. J Biol Chem. 1984; 259 (12): 7426-7432.
Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996; 97 (12): 2859-2865.
Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 1999; 103 (2): 253-259.
Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A. 1994; 91 (11): 4854-4858.
Thorell A, Efendic S, Gutniak M, Haggmark T, Ljungqvist O. Insulin resistance after abdominal surgery. Br J Surg. 1994; 81 (1): 59-63.
Svanfeldt M, Thorell A, Hausel J, Soop M, Nygren J, Ljungqvist O. Effect of "preoperative" oral carbohydrate treatment on insulin action--a randomised cross-over unblinded study in healthy subjects. Clin Nutr. 2005; 24 (5): 815-821
Awad S, Varadhan KK, Ljungqvist O, Lobo DN. A meta-analysis of randomised controlled trials on preoperative oral carbohydrate treatment in elective surgery. Clin Nutr. 2013; 32 (1): 34-44.
Clarke RS. The hyperglycaemic response to different types of surgery and anaesthesia. Br J Anaesth. 1970; 42 (1): 45-53.
Rehman HU, Mohammed K. Perioperative management of diabetic patients. Curr Surg. 2003; 60 (6): 607-611.
Desborough JP, Jones PM, Persaud SJ, Landon MJ, Howell SL. Isoflurane inhibits insulin secretion from isolated rat pancreatic islets of Langerhans. Br J Anaesth. 1993; 71 (6): 873-876.
Duggan EW, Carlson K, Umpierrez GE. Perioperative hyperglycemia management: an update. Anesthesiology. 2017; 126 (3): 547-560. doi: 10.1097/ALN.0000000000001515.
American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care. 2020; 43 (Suppl 1): S14-S31.
Robinson C, McGinlay M, Mruthunjaya S. Perioperative management of diabetes. Anaesth Intensive Care Med. 2020. doi: 10.1016/j.mpaic.2020.08.001.
Arslanian S, Bacha F, Grey M, Marcus MD, White NH, Zeitler P. Evaluation and management of youth-onset type 2 diabetes: a position statement by the american diabetes association. Diabetes Care. 2018; 41 (12): 2648-2668.
Welsh KJ, Kirkman MS, Sacks DB. Role of glycated proteins in the diagnosis and management of diabetes: research gaps and future directions. Diabetes Care. 2016; 39 (8): 1299-1306.
Selvin E, Wang D, Matsushita K, Grams ME, Coresh J. Prognostic implications of single-sample confirmatory testing for undiagnosed diabetes: a prospective cohort study. Ann Intern Med. 2018; 169 (3): 156-164.
Selvin E. Are there clinical implications of racial differences in HbA1c? A difference, to be a difference, must make a difference. Diabetes Care. 2016; 39 (8): 1462-1467.
Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2018; 391 (10120): 541-551.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK. Metformin in patients with type 2 diabetes and kidney disease: a systematic review. JAMA. 2014; 312 (24): 2668-2675.
Holman RR, Coleman RL, Chan JCN, Chiasson JL, Feng H, Ge J et al. Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017; 5 (11): 877-886.
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M et al. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med. 2016; 374 (14): 1321-1331.
Vaccaro O, Masulli M, Nicolucci A, Bonora E, Del Prato S, Maggioni AP et al. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial. Lancet Diabetes Endocrinol. 2017; 5 (11): 887-897.
Health and Social Care Information Centre. National Diabetes Inpatient Audit (NaDIA), Open data - 2013. 2014. Available in: http://www.hscic.gov.uk/catalogue/PUB14358
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z et al. Diabetes medications as monotherapy or metformin-based combination therapy for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med. 2016; 164 (11): 740-751.
Jia S, Wang Z, Han R, Zhang Z, Li Y, Qin X et al. Incretin mimetics and sodium-glucose co-transporter 2 inhibitors as monotherapy or add-on to metformin for treatment of type 2 diabetes: a systematic review and network meta-analysis. Acta Diabetol. 2021; 58 (1): 5-18.
Li T, Providencia R, Mu N, Yin Y, Chen M, Wang Y et al. Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2021; 20 (1): 30.
Abdi H, Azizi F, Amouzegar A. Insulin monotherapy versus insulin combined with other glucose-lowering agents in type 2 diabetes: a narrative review. Int J Endocrinol Metab. 2018; 16 (2): e65600.
Partridge H, Perkins B, Mathieu S, Nicholls A, Adeniji K. Clinical recommendations in the management of the patient with type 1 diabetes on insulin pump therapy in the perioperative period: a primer for the anaesthetist. Br J Anaesth. 2016; 116 (1): 18-26.
Guidelines for managing continuous subcutaneous insulin infusion therapy in hospitalised patients. DTN-UK.
Membership of the Working Party, Barker P, Creasey PE, Dhatariya K, Levy N, Lipp A et al. Peri-operative management of the surgical patient with diabetes 2015: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia. 2015; 70 (12): 1427-1440. doi: 10.1111/anae.13233.
Dhatariya K, Levy N, Kilvert A, Watson B, Cousins D, Flanagan D et al. NHS Diabetes guideline for the perioperative management of the adult patient with diabetes. Diabet Med. 2012; 29 (4): 420-433.
National Collaborating Centre for Acute Care (UK). Preoperative tests: the use of routine preoperative tests for elective surgery. London: National Collaborating Centre for Acute Care (UK); 2003. Available in: www.nice.org.uk/guidance/
Cook TM, Counsell D, Wildsmith JA; Royal College of Anaesthetists Third National Audit Project. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. Br J Anaesth. 2009; 102 (2): 179-190. Available in: www.rcoa.ac.uk/nap3
Simpson AK, Levy N, Hall GM. Peri-operative i.v. fluids in diabetic patients--don't forget the salt. Anaesthesia. 2008; 63 (10): 1043-1045.
National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. NICE guideline CG174, December 2013. Available in: www.nice.org.uk/guidance/cg174/
Joslin Diabetes Center and Joslin Clinic guideline for inpatient management of surgical and ICU patients with diabetes (pre, peri and postoperative care) 12 30 2015; updated 04/22/19.
Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009; 32 (7): 1335-1343.
Kittah NE, Vella A. Management of endocrine disease: pathogenesis and management of hypoglycemia. Eur J Endocrinol. 2017; 177 (1): R37-R47.
EVIDENCE LEVEL
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