2020, Number 3
<< Back Next >>
Enf Infec Microbiol 2020; 40 (3)
Antibiotic treatment compliance in ambulatory children, in the South of Mexico City
Ramírez SMLP, Varela RMA, Reyes GU
Language: Spanish
References: 15
Page: 87-91
PDF size: 235.06 Kb.
ABSTRACT
Objective. To know antibiotic treatment adherence in outpatient children, and to identify non-compliance related causes.
Method. Cross-sectional, prospective, descriptive and observational study. Children from six to 85 months of age who had been
prescribed an antibiotic in a first contact infectious diseases clinic, were included. Sociodemographic variables such as: age, sex,
parental education level, marital status of parents, social class of parents were studied.
Compliance Morisky-Green questionnaire and other characteristics related to the antibiotic indicated to the participants were
analyzed.
Results. 150 children were evaluated in six months, median age 12 months and average of 56.6 months (range six to 85 months).
Compliance with the questionnaire Morisky-Green was not adequate in 55% of the patients. Most frequent reasons for incorrect
administration or abandonment of treatment were: not waking up the child (43%), presenting improvement (28%). Other variables
associated with non-compliance with antibiotic treatment were: parents with secondary or higher scholar education, the
marital status of the parents.
Conclusions. More than half of the children who take antibiotics in primary care do not comply correctly with the prescribed
treatment. It is necessary that medical staff explain to the parents or guardians, the pharmacokinetics, pharmacodynamics and
days of administration, of each drug and to raise awareness of the importance of proper administration to their children.
REFERENCES
Ballester Vidal, M.R., De la Rosa Alarcón, L., Mansilla Ortuño, J., Tello Nieves, G., Ossa Moreno, M. y Párraga Martínez, I., “Cumplimiento del tratamiento antibiótico en niños en atención primaria”, Rev Clin Med Fam, 2014, 7 (1): 32-38.
who, Adherence to long term therapies: evidence for action, Ginebra, World Health Organization, 2003.
Haynes, R.B., “A critical review of the determinants of patient compliance therapeutic regimens”, en Sackett, D.L. y Haynes, R.B. (eds.), Compliance with therapeutic regimens, Baltimore, John Hopkins University Press, 1976, pp. 24-40.
Holmes, S.J., Morrow, A.L. y Pickering, L.K., “Child-care practices: effects of social change on the epidemiology of infectious diseases and antibiotic resistance”, Epidemiol Rev, 1996, 18: 10-28.
Vrijens, B. y Urquhart, J., “Patient adherence to prescribed antimicrobial drug dosing regimens”, J Antimicrob Chemother, 2005, 55: 616-627.
Cars, O., Mölstad, S. y Melander, A., “Variation in antibiotic use in the European Union”, Lancet, 2001, 357: 1851-1853.
Martínez-Mir, I. y Palop, V., “El problema del incumplimiento terapéutico en diferentes áreas”, en Sacristán, J.A., García, F.M., Martínez Mir, I., Palop, V. y Amado, E. (eds.), Cumplimiento terapéutico, Madrid, Biblioteca Lilly, 2001, pp. 73-86.
Silvestre, C., Ramalle, E., Arnáez, R., Flor, A., García, J., Ramil, H. et al., “Estudio multicéntrico sobre adhesión al tratamiento antibiótico en población infantil en atención primaria”, Aten Primaria, 2001, 27: 554-558.
Ramalle, E., Bermejo, R., Alonso, R., Mariño, I., Sáenz de Cabezón, M.I. y Villaro, C., “Cumplimiento del tratamiento antibiótico en niños no hospitalizados”, Aten Primaria, 1999, 24: 364-367.
Alexandre, A.I., “Ensayo clínico de intervención sobre el cumplimiento terapéutico con antibióticos en atención primaria de salud”, tesis doctoral, Universidad Miguel Hernández, San Juan de Alicante, España, 1999.
Llor, C., Sierra, N., Hernández, S., Moragas, A., Hernández, M., Bayona, C. et al., “The higher the number of daily doses of antibiotic treatment in lower respiratory tract infection the worse the adherence”, J Antimicrob Chemother, 2009, 63: 386-389.
Morisky, D.E., Green, L.W. y Levine, D.M., “Concurrent and predictive validity of a self-report measure of medication adherence”, Med Care, 1986, 24: 67-74.
Sanson-Fisher, R., Bowman, J. y Armstrong, S., “Factors affecting nonadherence with antibiotics”, Diagn Microbiol infect Dis, 1992, 151: 103-109.
Pichichero, M.E., Casey, J.R., Mayes, T., Francis, A.B., Marsocci, S.M., Murphy, A.M. et al., “Penicillin failure in streptococcal tonsillopharyngitis: causes and remedies”, Pediatr Infect Dis J, 2000, 19: 917-923.
Álvez, F., “Uso racional de antibióticos en las infecciones más comunes de los niños”, An Pediatr Contin, 2010, 8: 221-230.