2020, Número S1
<< Anterior Siguiente >>
Ginecol Obstet Mex 2020; 88 (S1)
Anticonceptivos orales combinados
Vásquez-Awad D, Ospino AM
Idioma: Español
Referencias bibliográficas: 79
Paginas: 13-31
Archivo PDF: 321.95 Kb.
RESUMEN
Los anticonceptivos orales combinados son los fármacos más prescritos y consumidos
en todo el mundo. La primera píldora anticonceptiva hormonal combinada se aprobó
en 1960 y desde su introducción al mercado han sucedido considerables cambios en su
composición, principalmente asociados con el tipo y la dosis de estrógenos y progestinas.
Los anticonceptivos orales combinados se clasifican de acuerdo con la concentración
de estrógenos y progestinas (monofásicos, bifásicos o trifásicos). Las progestinas más
prescritas incluyen: levonorgestrel, acetato de ciproterona, drospirenona, dienogest,
clormadinona y acetato de nomegestrol. Los anticonceptivos orales combinados pueden
prescribirse a cualquier paciente que busque un método de anticoncepción reversible.
Debe considerarse que los anticonceptivos orales combinados no protegen de las
enfermedades de trasmisión sexual. Entre los beneficios de los anticonceptivos orales
combinados están: regulación del ciclo menstrual; disminución del sangrado menstrual,
de la dismenorrea, de los síntomas premenstruales severos y del desorden disfórico
premenstrual. Incrementan la densidad mineral ósea, particularmente en los últimos
años de la vida reproductiva; disminución de los síntomas perimenopáusicos; control
del acné, disminución del hirsutismo, del riesgo de neoplasias benignas de la mama,
sobre todo de fibromas mamarios; reducción de la incidencia de salpingitis, del origen
de endometriomas relacionados con endometriosis; bajo riesgo de cáncer endometrial
y de ovario, y disminución del riesgo de carcinoma colorrectal. Los efectos secundarios
de los anticonceptivos orales combinados son comunes en los primeros tres meses de
tratamiento; sin embargo, desaparecen espontáneamente.
REFERENCIAS (EN ESTE ARTÍCULO)
Dragoman MV. The combined oral contraceptive pill -- recent developments, risks and benefits. Best Pract Res Clin Obstet Gynaecol 2014;28(6):825-834. https://doi. org/10.1016/j.bpobgyn.2014.06.003.
United Nations, Department of Economic and Social Affairs, Population Division (2017). World Contraceptive Use 2017 (POP/DB/CP/Rev2017 [en línea]. Dirección URL: .
Encuesta Nacional de Demografía y salud 2015. [en línea]. Dirección URL: .
Centers for Disease Control and Prevention. Achievements in public health, 1900-1999: family planning. MMWR Morb Mortal Wkly Rep 1999;48:1073-80. https://www.cdc.gov/ mmwr/preview/mmwrhtml/mm4847a1.htm
Sitruk-Ware R, et al. Contraception technology: past. Present and future. Contraception 2013;87(3):319-30. https:// doi.org/10.1016/j.contraception.2012.08.002.
Vásquez-Awad D, et al. Historia y farmacología de los esteroides y los estrógenos. En: Menopausia una visión clínica. Bogotá: Editorial Kimpres, 2016;49-75.
North American Menopause Society. Role of progestogen in hormone therapy for postmenopausal women: position statement of the North American Menopause Society. Menopause 2003;10(2):113-32.
Vásquez-Awad D, et al. Guías Latinoamericanas: Anticonceptivos orales combinados. Medicina (Bogotá) 2014;36(2):136-150. https://revistamedicina.net/ojsanm/ index.php/Medicina/article/view/105-4
Sánchez-Borrego R, et al. Guía práctica en anticoncepción oral basada en la evidencia. Sociedad Española de Contracepción. 2003. http://hosting.sec.es/descargas/ AH_2003_GuiaPracticaAnticOral.pdf.
Pérez E, et al. Anticoncepción hormonal combinada. Sociedad Española de Contracepción. http://sec.es/area-cientifica/ documentacion-cientifica/anticoncepcion-hormonal/.
Valero LP, et al. Planificación familiar: información general y seguimiento de anticonceptivos orales. http://www.san. gva.es/documents/246911/251004/guiasap029planfam. pdf.
Trussell J. Contraceptive failure in the United States. Contraception 2011;83:397-404. https://doi.org/10.1016/j. contraception.2011.01.021.
Dinger JC, et al. Oral contraceptive effectiveness according to body mass index, weight, age, and other factors. Am J Obstet Gynecol 2009;201:263.e1-9. https://doi. org/10.1016/j.ajog.2009.03.017.
Speroff L, et al. Oral contraception. A clinical guide for contraception. 5th ed. Philadelphia: Lippincott Williams and Wilkins, 2010.
Rossmanith WG, et al. Comparative randomized trial on the impact of two low-dose oral contraceptives on ovarian activity, cervical permeability, and endometrial receptivity. Contraception 1997;56:23-30.
World Healh Organization. Medical eligibility criteria for contraceptive use. 5th ed. 2015. http://apps.who.int/iris/ bitstream/handle/10665/181468/9789241549158_eng. pdf;jsessionid=D1F539419FBA8ABC84F098F3EB592F63 ?sequence=1.
Bahamondes L, et al. Non-contraceptive benefits of hormonal and intrauterine reversible contraceptive methods. Hum Reprod Update 2015;21:640-51. https:// doi.org/10.1093/humupd/dmv023.
Rosenberg MJ, et al. Efficacy, cycle control, and side effects of low- and lower-dose oral contraceptives: a randomized trial of 20 micrograms and 35 micrograms estrogen preparations. Contraception 1999;60:321-9
Bachmann G, et al. Bleeding patterns associated with oral contraceptive use: a review of the literature. Contraception 2007;76:182-9. https://doi.org/10.1016/j.contraception. 2007.05.081
van Vliet HA, et al. Triphasic versus monophasic oral contraceptives for contraception. Cochrane Database Syst Rev 2011;(11):CD003553. 10.1002/14651858.CD003553.pub3.
Ahrendt HJ, et al. Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel. Contraception 2009;80:436-44. https://doi.org/10.1016/j.contraception. 2009.03.018.
Kaunitz AM, et al. Cycle control with a 21-day compared with a 24-day oral contraceptive pill: a randomized controlled trial. Obstet Gynecol 2009;114(6):1205-12. https://doi. org/10.1097/AOG.0b013e3181beab47.
Archer DF, et al. Norethindrone acetate 1.0 milligram and ethinyl estradiol 10 micrograms as an ultra low-dose oral contraceptive. Obstet Gynecol 2013;122(3):601-7. https:// doi.org/10.1097/AOG.0b013e3182a1741c.
Redmond G, et al. Use of placebo controls in an oral contraceptive trial: methodological issues and adverse event incidence. Contraception 1999;60(2):81-5.
Gallo MF, et al. Combination contraceptives: effects on weight. Cochrane Database Syst Rev 2014;(1):CD003987. https://doi.org/10.1002/14651858.CD003987.pub5.
Keyes KM, et al. Association of hormonal contraceptive use with reduced levels of depressive symptoms: a national study of sexually active women in the United States. Am J Epidemiol 2013;178:1378-88. 10.1093/aje/kwt188.
Davis AR, et al. Oral contraceptives and libido in women. Ann Rev Sex Res 2004;15:297-320.
Elaut E, et al. Cycle-related changes in mood, sexual desire, and sexual activity in oral contraception-using and nonhormonalcontraception- using couples. J Sex Res 2014;53:1-12. https://doi.org/10.1080/00224499.2014.976780.
Graham CA, et al. The effects of steroidal contraceptives on the well-being and sexuality of women: a double blind, placebo-controlled, two-centre study of combined and progestogen-only methods. Contraception 1995;52:363-9.
Sabatini R, et al. Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives. Contraception 2006;74:220-3. https://doi. org/10.1016/j.contraception.2006.03.022
Pastor Z, et al. The influence of combined oral contraceptives on female sexual desire: a systematic review. Eur J Contracept Reprod Health Care 2013;18:27-43. https:// doi.org/10.3109/13625187.2012.728643.
Strufaldi R, et al. Effects of two combined hormonal contraceptives with the same composition and different doses on female sexual function and plasma androgen levels. Contraception 2010;82:147-54. 10.1016/j.contraception. 2010.02.016.
Vetvik KG, et al. Contraceptive-induced amenorrhoea leads to reduced migraine frequency in women with menstrual migraine without aura. J Headache Pain 2014;15:30. https://doi.org/10.1186/1129-2377-15-30
De Leo V, et al. Combine oral contraceptives in women with menstrual migraine without aura. Fertil Steril 2011;96:917- 20. https://doi.org/10.1016/j.fertnstert.2011.07.1089.
Handel AC, et al. Risk factors for facial melasma in women: a case-control study. Br J Dermatol 2014;171:588-94. 10.1111/bjd.13059.
Guinot C, et al. Aggravating factors for melasma: a prospective study in 197 Tunisian patients. J Eur Acad Dermatol Venereol 2010;24:1060e9. https://doi.org/10.1111/j.1468- 3083.2010.03592.x.
Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet 1996;347(1917):1713-27.
Narod SA, et al. Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Caner Inst 2002;94:1773-9.
Brohet RM, et al. Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group. J Clin Oncol 2007;25(25):3831- 6. https://doi.org/10.1200/JCO.2007.11.1179
Farley TM, et al. Hormonal contraception and risk of cardiovascular disease. An international perspective. Contraception 1998;57:211-30.
Roach RE, et al. Combined oral contraceptives: the risk of myocardial infarction and ischemic stroke. Cochrane Database Syst Rev 2015:27(8):CD011054. https://doi. org/10.1002/14651858.CD011054.pub2.
Bennion LJ, et al. Effects of oral contraceptives on the gallbladder bile of normal women. New Engl J Med 1976;294:189- 92. https://doi.org/10.1056/NEJM197601222940403
Benign gallbladder disease: newer data suggest little or no excess risk with oral contraceptive use. Contracept Rep 1997;8(5):9-11.
Jick S, et al. Drospirenone- and levonorgestrel-containing oral contraceptives and the risk of gallbladder disease. Contraception 2012;86:220-3. https://doi.org/10.1016/j. contraception.2012.01.006.
Moorman PG, et al. Oral contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis. J Clin Oncol 2013;31(33):4188-98. https://doi.org/10.1200/ JCO.2013.48.9021.
Iodice S, et al. Oral contraceptive use and breast or ovarian cancer risk in BRCA1/2 carriers: a meta-analysis. Eur J Cancer 2010;46:2275-84. https://doi.org/10.1016/j. ejca.2010.04.018.
Vessey M, et al. Oral contraceptive use and cancer: final report from the Oxford-Family Planning Association contraceptive study. Contraception 2013;88:678-83. https:// doi.org/10.1016/j.contraception.2013.08.008.
Moreno V, et al. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study. Lancet 2002;359:1085-92. https://doi.org/10.1016/S0140- 6736(02)08150-3
International Collaboration of Epidemiological Studies of Cervical Cancer, Appleby P, Beral V, Berrington de González A, et al. Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet 2007;370:1609-21. https://doi.org/10.1016/S0140-6736(07)61684-5
Oh HY, et al. Association of combined tobacco smoking and oral contraceptive use with cervical intraepithelial neoplasia 2 or 3 in Korean women. J Epidemiol 2016;26:22- 9. https://doi.org/10.2188/jea.JE20150047.
Dinger JC, et al. The safety of a drospirenone containing oral contraceptive: final results from the European Active Surveillance Study on oral contraceptives based on 142,475 women-years of observation. Contraception 2007;75:344- 54. https://doi.org/10.1016/j.contraception.2006.12.019
Sidney S, et al. Recent combined hormonal contraceptives (CHCs) and the risk of thromboembolism and other cardiovascular events in new users. Contraception 2013;87:93- https://doi.org/100. 10.1016/j.contraception.2012.09.015.
Shulman LP. Oral contraceptives: risks. Obstet Gynecol Clin N Am 2000;27:695-704.
Mikkelsen EM, et al. Pre-gravid oral contraceptive use and time to pregnancy: a Danish prospective cohort study. Hum Reprod 2013;28:1398-405. https://doi.org/10.1093/ humrep/det023.
Mansour D, et al. Fertility after discontinuation of contraception: a comprehensive review of the literature. Contraception 2011;84:465-77. https://doi.org/10.1016/j. contraception.2011.04.002.
Briggs GC, et al. Drugs in pregnancy and lactation. 10th ed. Philadelphia: Wolters Kluwer Health; 2014. https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4989726/
Charlton BM, et al. Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study. BMJ 2016;352:h6712. https://doi. org/10.1136/bmj.h6712
Allen RH, et al. Contraception in women over 40 years of age. CMAJ 2013;185(7):565-73. https://doi.org/10.1503/ cmaj.121280
Palli MB, et al. A single-center, randomized double-blind, parallel-group study to examine the safety and efficacy of 3mg drospirenone/0.02mg ethinyl estradiol comparedwith placebo in the treatment of moderate truncal acne vulgaris. J Drugs Dermatol 2013;12(6):633-7.
Kelly S, et al. Effects of oral contraceptives containing ethinylestradiol with either drospirenone or levonorgestrel on various parameters associated with well-being in healthy women: a randomized, single-blind, parallel-group, multicentre study. Clin Drug Investig 2010;30:325-36. https:// doi.org/10.2165/11535450-000000000-00000.
Arowojolu AO, et al. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev 2012;(7):CD004425. https://doi.org/10.1002/14651858. CD004425.pub6.
Vessey M, et al. Oral contraceptive use and cancer. Findings in a large cohort study, 1968-2004. Br J Cancer 2006;95:385-9. https://doi.org/10.1038/sj.bjc.6603260
Cibula D, et al. Hormonal contraception and risk of cancer. Hum Reprod Update 2010;16:631-50. https://doi. org/10.1093/humupd/dmq022.
Collaborative Group on Epidemiological Studies on Endometrial Cancer. Endometrial cancer and oral contraceptives: an individual participant meta-analysis of 27 276 women with endometrial cancer from 36 epidemiological studies. Lancet Oncol 2015;16(9):1061-70. https:// www.thelancet.com/journals/lanonc/article/PIIS1470- 2045(15)00212-0/fulltext
Vessey M, et al. Factors affecting mortality in a large cohort study with special reference to oral contraceptive use. Contraception 2010;82:221-9. https://doi.org/10.1016/j. contraception.2010.04.006.
Gross TP, et al. The estimated effect of oral contraceptive use on the cumulative risk of epithelial ovarian cancer. Obstet Gynecol 2003;83:419-24
Bosetti C, et al. Oral contraceptives and colorectal cancer risk: a systematic review and meta-analysis. Hum Reprod Update 2009;15:489-98. https://doi.org/10.1093/humupd/ dmp017.
Curtis KM, et al. U.S. selected practice recommendations for contraceptive use, 2016. MMWR Recomm Rep 2016;65(4):1-66. https://doi.org/10.15585/mmwr. rr6504a1.
Westhoff C, et al. Bleeding patterns after immediate vs. conventional oral contraceptive initiation: a randomized, controlled trial. Fertil Steril 2003;79:322-9.
Brahmi D, et al. When can a woman start combined hormonal contraceptives (CHCs)? A systematic review. Contraception 2013;87:524-38. https://doi.org/10.1016/j. contraception.2012.09.010.
Halbe HW, et al. Efficacy and acceptability of two monophasic oral contraceptives containing ethinylestradiol and either desogestrel or gestodene. Eur J Contracept Reprod Health Care 1998;3:113-20.
Archer DF, et al. Efficacy and safety of a low-dose monophasic combination oral contraceptive containing 100 microg levonorgestrel and 20 microg ethinyl estradiol (Alesse). Am J Obstet Gynecol 1999;181:39e44.
Rosenberg MJ, et al. The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception 1996;53(2):85-90.
Grossman MP, et al. Menstrual cycle bleeding patterns in cigarette smokers. Contraception 2006;73:562-5. https:// doi.org/10.1016/j.contraception.2006.01.016
Murphy PA, et al. Interaction of St. John’s Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contraception 2005;71(6):402-8. https://doi.org/10.1016/j.contraception. 2004.11.004
Dinger J, et al. Effectiveness of oral contraceptive pills in a large U.S. cohort comparing progestogen and regimen. Obstet Gynecol 2011;117(1):33-40.
Dinger JC, et al. Oral contraceptive effectiveness according to body mass index, weight, age, and other factors. Am J Obstet Gynecol 2009;201:263.e1-9. 10.1016/j. ajog.2009.03.017.
Lopez LM, et al. Skin patch and vaginal ring versus combined oral contraceptives for contraception. Cochrane Database Syst Rev 2013;(4):CD003552. https://doi. org/10.1002/14651858.CD003552.pub4.
Cozza KL, et al. The concise guide to the cytochrome P450 system: drug interaction principles for medical practice. Washington: American Psychiatric Publishing, 2001;103-14. https://doi.org/10.1034/j.1600- 0447.2003.01024_1.x