2019, Número 3
Uso de aceites esenciales como agentes quimiopreventivos contra el cáncer colorrectal
Páez-Hernández G, Espinosa-Andrews H, Castillo-Herrera GA, Herrera-Rodríguez SE
Idioma: Español
Referencias bibliográficas: 45
Paginas: 199-206
Archivo PDF: 395.91 Kb.
RESUMEN
Introducción: La incidencia del cáncer colorrectal
ha incrementado en los últimos años. En México, es el
tercer tipo de cáncer con mayor prevalencia tanto para
hombres como para mujeres. Suele ser asintomático en
las primeras etapas, por lo que es detectado en etapas
avanzadas cuando representa una enfermedad incurable.
Además, los tratamientos aplicados para tratar el cáncer
colorrectal presentan efectos secundarios adversos que
comprometen la salud del paciente. Por tal motivo,
actualmente se está promoviendo el uso de compuestos
naturales como agentes quimiopreventivos. Los aceites
esenciales son mezclas complejas de compuestos volátiles,
provenientes de diversas fuentes naturales.
Objetivo:
Esta revisión discute el potencial terapéutico y los
mecanismos de acción de aceites esenciales en diversas
líneas celulares de cáncer colorrectal.
Resultados y
conclusiones: Diversos estudios han demostrado que los
aceites esenciales presentan un efecto anticancerígeno
en diferentes líneas celulares de cáncer colorrectal, por
lo que representan una alternativa efectiva como agentes
quimiopreventivos y coadyuvantes en el tratamiento
contra el cáncer colorrectal.
REFERENCIAS (EN ESTE ARTÍCULO)
IARC. World Cancer Report 2014. Wild BWS and CP, editor. 2014.
Salud OM de la. Cáncer [Internet]. 2017. Disponible en: http://www. who.int/mediacentre/factsheets/fs297/es/
Secretaría de Salud. 160 mil nuevos casos de cáncer al año en México [Internet]. 2016. Disponible en: https://www.gob.mx/salud/ prensa/160-mil-nuevos-casos-de-cancer-al-ano-en-mexico
Ferlay J, Soerjomataram I I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359- 386.
Bogaert J, Prenen H. Molecular genetics of colorectal cancer. Ann Gastroenterol. 2014;27(1):9–14.
Fearon ERR. Molecular Genetics of Colorectal Cancer. Annu Rev Pathol. 2011;6:479–507.
Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin. 2000;50(1):7–33.
Sociedad Americana contra el Cáncer. Cirugía del cáncer de colon [Internet]. 2017. Disponible en: https://www.cancer.org/ es/cancer/cancer-de-colon-o-recto/tratamiento/cirugia-delcolon. html
Sociedad Americana contra el Cáncer. Radioterapia para el cáncer colorrectal [Internet]. 2017. Disponible en: https://www. cancer.org/es/cancer/cancer-de-colon-o-recto/tratamiento/ radioterapia.html#escrito_por
Sociedad Americana contra el Cáncer. Quimioterapia para el cáncer colorrectal [Internet]. 2017. Disponible en: https://www.cancer.org/es/ cancer/cancer-de-colon-o-recto/tratamiento/quimioterapia.html
Labianca R, Pessi MA, Zamparelli G. Treatment of Colorectal Cancer. Drugs. 1997;53(4):593–607.
Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N, et al. Drug resistance in cancer: An overview. Cancers (Basel). 2014;6(3):1769–92.
Pardini B, Kumar R, Naccarati A, Novotny J, Prasad RB, Forsti A, et al. 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/ MTRR genotypes. Br J Clin Pharmacol. 2011;72(1):162–3.
Gerber DE. Targeted therapies: A new generation of cancer treatments. Am Fam Physician. 2008;77(3):311–9.
Rejhová A, Opattová A, Čumová A, Slíva D, Vodička P. Natural compounds and combination therapy in colorectal cancer treatment. Eur J Med Chem. 2018;144:582–94.
Weng CJ, Yen GC. Chemopreventive eff ects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev. 2012;38(1):76–87.
Yang CS, Wang H, Dan V, Filippo SS. Cancer Chemoprevention: What Have we Learned? Curr Pharmacol Reports. 2017;3(6):409–22.
Edris AE. Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review. Phyther Res. 2007;21(4):308–23.
Gautam N, Mantha AK, Mittal S, Gautam N, Mantha AK, Mittal S. Essential Oils and Th eir Constituents as Anticancer Agents: A Mechanistic View. Biomed Res Int. 2014;2014, 2014:e154106.
Sharma SH, Th ulasingam S, Nagarajan S. Terpenoids as anti-colon cancer agents – A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017;795(April 2016):169–78.
Ong TP. Dietary Essential Oils and Cancer Chemopreventive Potential. In: Bioactive Essential Oils and Cancer. 2015. p. 237–50.
Bayala B, Bassole IH, Scifo R, Gnoula C, Morel L, Lobaccaro J-MA, et al. Anticancer activity of essential oils and their chemical components - a review. Am J Cancer Res. 2014;4(6):591–607.
Patel S, Gogna P. Tapping botanicals for essential oils: Progress and hurdles in cancer mitigation. Ind Crops Prod. 2015;76:1148–63.
Begnini KR, Nedel F, Lund RG, Carvalho PH de A, Rodrigues MRA, Beira FTA, et al. Composition and Antiproliferative Eff ect of Essential Oil of Origanum vulgare Against Tumor Cell Lines. J Med Food. 2014;17(10):1129–33.
Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological eff ects of essential oils - A review. Food Chem Toxicol. 2008;46(2):446–75.
Raut JS, Karuppayil SM. A status review on the medicinal properties of essential oils. Ind Crops Prod. 2014;62:250–64.
Saikumar P, Dong Z, Mikhailov V, Denton M, Weinberg JM, Venkatachalam MA. Apoptosis: Defi nition, mechanisms, and relevance to disease. Am J Med. 1999;107(5):489–506.
Patil JR, Jayaprakasha GK, Chidambara Murthy KN, Tichy SE, Chetti MB, Patil BS. Apoptosis-mediated proliferation inhibition of human colon cancer cells by volatile principles of Citrus aurantifolia. Food Chem. 2009;114(4):1351–8.
Cha JD, Kim YH, Kim JY. Essential oil and 1,8-cineole from Artemisia lavandulaefolia induces apoptosis in KB Cells via mitochondrial stress and caspase activation. Food Sci Biotechnol. 2010;19(1):185–91.
Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat. 2004;7(2):97–110.
Sheikh BY, Sarker MMR, Kamarudin MNA, Mohan G. Antiproliferative and apoptosis inducing eff ects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. Biomed Pharmacother. 2017;96:834–46.
Itani WS, El-Banna SH, Hassan SB, Larsson RL, Bazarbachi A, Gali- Muhtasib HU. Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. Cancer Biol Th er. 2008;7(11):1765–73.
Jaganathan SK, Mazumdar A, Mondhe D, Mandal M. Apoptotic eff ect of eugenol in human colon cancer cell lines. Cell Biol Int. 2011;35(6):607–15.
Jeong JB, Choi J, Lou Z, Jiang X, Lee SH. Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. Int Immunopharmacol. 2013;16(2):184–90.
Nishida N, Yano H, Nishida T, Kamura T, Kojiro M. Angiogenesis in cancer. Vasc Health Risk Manag. 2006;2(3):213–9.
Murthy KNC, Jayaprakasha GK, Patil BS. D-limonene rich volatile oil from blood oranges inhibits angiogenesis , metastasis and cell death in human colon cancer cells. LFS. 2012;91(11–12):429–39.
Donadu MG, Usai D, Mazzarello V, Molicotti P, Cannas S, Bellardi MG, et al. Change in Caco-2 cells following treatment with various lavender essential oils. Nat Prod Res. 2017;31(18):2203–6.
Sharma PR, Mondhe DM, Muthiah S, Pal HC, Shahi AK, Saxena AK, et al. Anticancer activity of an essential oil from Cymbopogon fl exuosus. Chem Biol Interact. 2009;179(2–3):160–8.
Piras A, Rosa A, Marongiu B, Atzeri A, Dessì MA, Falconieri D, et al. Extraction and Separation of Volatile and Fixed Oils from Seeds of Myristica fragrans by Supercritical CO 2: Chemical Composition and Cytotoxic Activity on Caco-2 Cancer Cells. J Food Sci. 2012;77(4):448– 53.
Gomide M da S, Lemos F de O, Lopes MTP, Alves TM de A, Viccini LF, Coelho CM. Th e eff ect of the essential oils from fi ve diff erent Lippia species on the viability of tumor cell lines. Rev Bras Farmacogn. 2013;23(6):895–902.
Da Silva JKR, Pinto LC, Burbano RMR, Montenegro RC, Andrade EHA, Maia JGS. Composition and cytotoxic and antioxidant activities of the oil of Piper aequale Vahl. Lipids Health Dis. 2016;15(1):1–6.
Rashid S, Rather MA, Shah WA, Bhat BA. Chemical composition, antimicrobial, cytotoxic and antioxidant activities of the essential oil of Artemisia indica Willd. Food Chem. 2013 May 1;138(1):693–700.
Yousefzadi M, Riahi-Madvar A, Hadian J, Rezaee F, Rafi ee R, Biniaz M. Toxicity of essential oil of Satureja khuzistanica: In vitro cytotoxicity and anti-microbial activity. J Immunotoxicol. 2014;11(1):50–5.
de Oliveira PF, Alves JM, Damasceno JL, Oliveira RAM, Júnior Dias H, Crotti AEM, et al. Cytotoxicity screening of essential oils in cancer cell lines. Brazilian J Pharmacogn. 2015;25(2):183–8.
Sylvestre M, Legault J, Dufour D, Pichette A. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. Phytomedicine. 2005;12(4):299–304.