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2019, Número 4

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Rev Educ Bioquimica 2019; 38 (4)


Lipoproteínas de alta densidad y riesgo cardiovascular

Hernández PG, Laguna MKD, Reyes GM, Moreno PJR, Matuz MD

Idioma: Español
Referencias bibliográficas: 44
Paginas: 93-99
Archivo PDF: 460.54 Kb.


RESUMEN

Los lípidos son moléculas altamente hidrofóbicas y por lo tanto insolubles en el componente acuoso de la sangre, por lo que deben ser transportados a través de lipoproteínas. Las lipoproteínas de alta densidad (HDL) son las más pequeñas, con el mayor contenido de apoproteínas y menor contenido de triacilgliceroles (TAG); se sintetizan en el hígado e intestino, remueven el colesterol de los tejidos periféricos y lo regresan al hígado, por lo que tradicionalmente se les ha conferido el papel protector en la aterogénesis. Existen diferentes subtipos de HDL, uno de los cuales, el subtipo de HDL pre-β1, a diferencia del papel protector del resto, se ha relacionado con el desarrollo de la ateroesclerosis. El presente artículo tiene como objetivo revisar la interacción de las HDL con otras proteínas que la remodelan, afectando su composición y/o función, así como la asociación de un subtipo de HDL con el riesgo cardiovascular.


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