2019, Número 12
<< Anterior Siguiente >>
Ginecol Obstet Mex 2019; 87 (12)
Istmocele: una revisión sistemática de la literatura
Alkon-Meadows T, Luna-Rojas M, Hernández-Nieto C, Sandler B
Idioma: Español
Referencias bibliográficas: 35
Paginas: 820-831
Archivo PDF: 519.66 Kb.
RESUMEN
Objetivo: Revisar la bibliografía de la prevalencia, factores de riesgo, síntomas,
diagnósticos y tratamiento de las pacientes con istmocele.
Método: Búsqueda electrónica en las bases de datos: PubMed, EMBASE y Google
Scholar. Se utilizaron los siguientes términos, palabras y sus combinaciones: “Cesarean
section defect, uterine niche, isthmocele, uterine sacculation, uterine diverticulum,
uterine pouch, isthmocele diagnosis, segmentocele y isthmocele treatment”. La variable
primaria estudiada fueron los síntomas asociados con el istmocele. Las variables
secundarias: prevalencia, factores de riesgo, diagnóstico y tratamiento.
Resultados: Se reunieron 549 artículos de los que se eliminaron 288 por duplicidad
y 228 no cumplieron los criterios de inclusión; al final solo se analizaron 33 artículos. El
istmocele tiene una prevalencia de 15 a 84% en mujeres con antecedente de cesárea.
Su incidencia se correlaciona directamente con la cantidad de cesáreas previas. Su
aparición puede ser sintomática o asintomática. La manifestación clínica más común
es el sangrado uterino anormal, que sucede en 28.9 a 82% de los casos. Incluso 88%
se diagnostican en el ultrasonido transvaginal. La histeroscopia quirúrgica se asoció
con disminución de los síntomas en 56.9 a 100%.
Conclusiones: El istmocele suele identificarse de manera fortuita en el ultrasonido
transvaginal y casi siempre es asintomático. Puede ocasionar sangrado uterino anormal
e infertilidad secundaria. Su prevalencia depende del método diagnóstico utilizado.
La histeroscopia es el método de tratamiento más efectivo.
REFERENCIAS (EN ESTE ARTÍCULO)
Di Spiezio Sardo A, Saccone G, McCurdy R, Bujold E, Bifulco G, Berghella V. Risk of Cesarean scar defect following single- vs double-layer uterine closure: systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstet Gynecol. 2017;50:578-583. DOI: 10.1002/ uog.18911
Morris H. Surgical pathology of the lower uterine segment caesarean section scar: is the scar a source of clinical symptoms? Int J Gynecol Pathol. 1995;14:16-20. PMID:7883420
Bij de Vaate AJ, Brolmann HA, van der Voet LF, van der Slikke JW, Veersema S, Huirne JA. Ultrasound evaluation of the Cesarean scar: relation between a niche and postmenstrual spotting. Ultrasound Obstet Gynecol 2011; 37: 93–99. DOI:10.1002/uog.8864
Gubbini G, Casadio P, Marra E. Resectoscopic correction of the “isthmocele” in women with postmenstrual abnormal uterine bleeding and secondary infertility. J Minim Invasive Gynecol. 2008;15:172– 175. DOI: 10.1016/j. jmig.2007.10.004.
Gubbini G, Centini G, Nascetti D, et al. Surgical hysteroscopic treatment of cesarean-induced isthmocele in restoring fertility: prospective study. J Minim Invasive Gynecol. 2011;18:234–237. DOI: 10.1016/j.jmig.2010.10.011.
Borges LM, Scapinelli A, Depes D, Lippi U, Lopes R. Findings in patients with postmenstrual spotting with prior cesarean section. J Minim Invasive Gynecol. 2010;17:361–364. DOI: 10.1016/j.jmig.2010.02.007.
Thurmond AS, Harvey WJ, Smith SA. Cesarean section scar as a cause of abnormal vaginal bleeding: diagnosis by sonohysterography. J Ultrasound Med. 1999;18:13–16. DOI:10.7863/jum.1999.18.1.13
Fabres C, Aviles G, De La Jara C, et al. The cesarean delivery scar pouch: clinical implications and diagnostic correlation between transvaginal sonography and hysteroscopy. J Ultrasound Med. 2003;22: 695–700. DOI:10.7863/ jum.2003.22.7.695
Osser OV, Jokubkiene L, Valentin L. High prevalence of defects in cesarean section scars at transvaginal ultrasound examination. Ultrasound Obstet Gynecol. 2009;34:90–97. DOI: 10.1002/uog.6395.
Ofili-Yebovi D, Ben-Nagi J, Sawyer E, et al. Deficient lower-segment cesarean section scars: prevalence and risk factors. Ultrasound Obstet Gynecol. 2008;31:72–77. DOI:10.1002/uog.5200
Armstrong V, Hansen WF, Van Voorhis BJ, Syrop CH. Detection of cesarean scars by transvaginal ultrasound. Obstet Gynecol. 2003;101: 61–65. DOI:10.1016/s0029- 7844(02)02450-x
Wang CB, Chiu WW, Lee CY, et al. Cesarean scar defect: correlation between cesarean section number, defect size, clinical symptoms and uterine position. Ultrasound Obstet Gynecol. 2009;34:85–89. DOI:10.1002/uog.6405
Wang CJ, Huang HJ, Chao A, et al. Challenges in the transvaginal management of abnormal uterine bleeding secondary to cesarean section scar defect. Eur J Obstet Gynecol Reprod Biol. 2011;154: 218–222. 21. DOI:10.1016/j. ejogrb.2010.10.016
Osser OV, Jokubkiene L, Valentin L. Cesarean section scar defects: agreement between transvaginal sonographic findings with and without saline contrast enhancement. Ultrasound Obstet Gynecol. 2010;35:75–83. DOI:10.1002/uog.7496
Fabres C, Arriagada P, Fernandez C, et al. Surgical treatment and follow-up of women with intermenstrual bleeding due to cesarean section scar defect. J Minim Invasive Gynecol. 2005;12: 25–28. DOI:10.1016/j.jmig.2004.12.023
Feng YL, Li MX, Liang XQ, Li XM. Hysteroscopic treatment of postcesarean scar defect. J Minim Invasive Gynecol. 2012;19: 498–502. DOI:10.1016/j.jmig.2012.03.010
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health-care interventions: explanation and elaboration. BMJ 2009;339: b2700. DOI:10.1016/j.jclinepi.2009.06.006
Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M; STROBE Initiative. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med 2007;4: e297. DOI:10.1016/j. ijsu.2014.07.014
Pomorski M, Fuchs T, Zimmer M. Prediction of uterine dehiscence using ultrasonographic parameters of cesarean section scar in the nonpregnant uterus: a prospective observational study. BMC Pregnancy and Childbirth. 2014;14:365. DOI:10.1186/s12884-014-0365-3
Monteagudo A, Carreno C, Timor-Tritsch IE. Saline infusion sonohysterography in nonpregnant women with previous cesarean delivery: the ‘‘niche’’ in the scar. J Ultrasound Med.2001;20:1105–1115. DOI:10.7863/ jum.2001.20.10.1105
Chang Y, Tsai EM, Long CY, Lee CL, Kay N. Resectoscopic treatment combined with sonohysterographic evaluation of women with postmenstrual bleeding as a result of previous cesarean delivery scar defects. Am J Obstet Gynecol. 2009;200:370.e1–370.e4. DOI:10.1016/j. ajog.2008.11.038
Hayakawa H, Itakura A, Mitsui T, et al. Methods for myometrium closure and other factors impacting effects on cesarean section scars of the uterine segment detected by the ultrasonography. Acta Obstet Gynecol Scand. 2006;85:429–434. DOI:10.1080/00016340500430436
Yazicioglu F, Gokdogan A, Kelekci S, Aygun M, Savan K. Incomplete healing of the uterine incision after caesarean section: Is it preventable? Eur J Obstet Gynecol Reprod Biol. 2006;124: 32 – 36. DOI:10.1016/j.ejogrb.2005.03.023
Vervoort AJ, Van der Voet LF, Witmer M, Thurkow AL, Radder CM, van Kesteren PJ, et al. The HysNiche trial: hysteroscopic resection of uterine caesarean scar defect (niche) in patients with abnormal bleeding, a randomised controlled trial. BMC Women's Health. 2015;15:103. DOI:10.1186/s12905-015-0260-8
Vervoort A, Vissers J, Hehenkamp W, Brölmann H, Huirne J. The effect of laparoscopic resection of large niches in the uterine caesarean scar on symptoms, ultrasound findings and quality of life: a prospective cohort study. BJOG. 2018;125(3):317-25. DOI:10.1111/1471- 0528.14822
Zhang Y. A comparative study of transvaginal repair and laparoscopic repair in the management of patients with previous cesarean scar defect. J Minim Invasive Gynecol. 2016;23(4):535-41. DOI:10.1016/j.jmig.2016.01.007
Luo L, Niu G, Wang Q, Xie HZ, Yao SZ. Vaginal repair of cesarean section scar diverticula. J Minim Invasive Gynecol. 2012;19:454–458. DOI:10.1016/j.jmig.2012.03.012
Raimondo G, et al. Hysteroscopic treatment of symptomatic cesarean induced isthmocele: a prospective study. J Minim Invasive Gynecol. 2015; 22: 297-301.:10.1016/j. jmig.2014.09.011
Melo-Cerda I. Importancia ginecológica del istmocele ¿cómo y cuándo tratar? Ginecol Obstet Mex 2017 feb; 85 (2): 55-63. http://www.scielo. org.mx/scielo.php?script=sci_arttext&pid=S0300- 90412017000200055
Menada Valenzano M, et al. Vaginal ultrasonographic and hysterosonographic evaluation of the low transverse incision after caesarean section: correlation with gynecological symptoms. Gynecol Obstet Invest. 2006; 61:216-22. doi:10.1159/000091497
Chen HY, Chen SJ, Hsieh FJ. Observation of cesarean section scar by transvaginal ultrasonography. Ultrasound Med Biol. 1990; 16: 443-47. PMID:2238250
Regnard C, et al. Cesarean section scar evaluation by saline contrast sonohysterography. Ultrasoundm Obstet Gynecol. 2004; 23: 289-92. doi:10.1002/uog.999
Uppal T, et al. Sonographically detected caesarean section scar defects and menstrual irregularity. J Obstet Gynaecol. 2011; 31: 413-16. https://doi.org/10.3109/01443615.2 011.577252
El-Mazny A, et al. Diagnostic correlation between sonohysterography and hysteroscopy in the assessment of uterine cavity after cesarean section. Middle East Fertil Soc J. 2011; 16: 72-76. https://doi.org/10.1016/j. mefs.2010.07.015
Borges LM, et al. Findings in patients with postmenstrual spotting with prior cesarean Section. J Minim Invasive Gynecol. 2010; 17: 361-64. doi:10.1016/j.jmig.2010.02.007