Carrillo ER, Carvajal RR

Idioma: Español
Referencias bibliográficas: 40
Paginas: 238-245
Archivo PDF: 109.54 Kb.

RESUMEN

La sepsis es la respuesta inflamatoria sistémica a la infección y es una de las principales causas de ingreso a las unidades de terapia intensiva. Se asocia a una elevada mortalidad. Es secundaria a la interacción de la respuesta inmune innata con microorganismos, lo que resulta en daño endotelial y coagulopatía que puede evolucionar a trombosis microvascular, hipoxia y disfunción orgánica múltiple. El diagnóstico temprano y oportuno es fundamental. El tratamiento está dirigido al control del disparador, al empleo racional de antibióticos, reanimación temprana y agresiva, control metabólico y otras medidas de sostén. La proteína C activada recombinante humana disminuye significativamente la mortalidad y está indicada en pacientes con sepsis grave que presenten APACHE II > 25 puntos, choque séptico y disfunción orgánica múltiple.

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