medigraphic.com
Academia Mexicana de Neurología, A.C.

2016, Número 5

<< Anterior Siguiente >>

Rev Mex Neuroci 2016; 17 (5)


Similitudes y diferencias en la sintomatología obsesivo-compulsiva y autista: aportaciones desde la neurociencia

Martínez-González AE, Piqueras JA, Pineda-Sánchez D

Idioma: Español
Referencias bibliográficas: 73
Paginas: 70-82
Archivo PDF: 317.66 Kb.


RESUMEN

En los últimos años diversos estudios internacionales han destacado la importancia de las variables transdiagnósticas comunes a diferentes trastornos mentales. En el caso concreto de los trastornos del espectro obsesivo-compulsivo y del espectro autista, éstos comparten síntomas comunes relacionados con la conducta repetitiva. El presente estudio tiene el objetivo de realizar una revisión sobre las semejanzas y diferencias neuropsicológicas y de neuroimagen cerebral entre el TOC y el autismo. Se concluye que existen aspectos sintomatológicos similares como las conductas repetitivas y alteraciones en las funciones ejecutivas entre ambos trastornos. Sin embargo, los sujetos con autismo presentan alteraciones generalizadas en los distintos tipos de memoria y una disminución de la actividad cerebral en diversas estructuras neuronales, mientras que los sujetos con trastorno obsesivo-compulsivo presentan déficits más concretos en la memoria no verbal e hiperactividad funcional en los lóbulos frontales y córtex cingulado anterior.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (5th ed., text revision). Washington, DC.: American Psychiatric Association; 2013.

  2. Canals J, Hernández-Martínez C, Cosi S, Voltas N. The epidemiology of obsessive-compulsive disorder in Spanish school children. J Anxiety Disord. 2012;26: 746–752.

  3. Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry.2010; 15(1): 53-63.

  4. Fullana MA, Vilagut G, Rojas-Farreras S, Mataix-Cols D, De Graaf R, DemyttenaereK, et al. Obsessive-compulsive symptom dimensions in the general population: Results from an epidemiological study in six European countries. J Affect Disord. 2010;124(3): 291–299.

  5. Sun J, Li Z, Buys N, Storch EA. Correlates of comorbid depression, anxiety and helplessness with obsessive–compulsive disorder in Chinese adolescents. J Affect Disord . 2015; 174: 31-37.

  6. Weinberg A, Kotov R, Proudfit GH. Neural indicators of error processing in generalized anxiety disorder, obsessive-compulsive disorder, and major depressive disorder.J Abnorm Psychol. 2015; 124: 172-185.

  7. Leckman JF, Denys D, Simpson HB, Mataix‐Cols D, Hollander E, Saxena S, et al. Obsessive– compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V. Depress Anxiety. 2010;27(6): 507-527.

  8. Gillberg C. The ESSENCE in child psychiatry: early symptomatic syndromes eliciting neurodevelopmental clinical examinations. Res Dev Disabil. 2010; 31(6): 1543-1551.

  9. Eddy CM, Cavanna AE. Tourette syndrome and obsessive compulsive disorder: Compulsivity along the continuum. J Obsessive Compuls Relat Disord. 2014; 3(4): 363–371.

  10. Paula-Pérez, I. Diagnóstico diferencial entre el trastorno obsesivo compulsivo y los patrones de comportamiento, actividades e intereses restringidos y repetitivos en los trastornos del espectro autista. Rev Psiquiatr Salud Ment. 2013; 6(4): 178-186.

  11. Ruzzano L, Borsboom D, Geurts HM. Repetitive Behaviors in Autism and Obsessive–Compulsive Disorder: New Perspectives from a Network Analysis. J Autism Dev Disord.2015; 45(1): 192-202.

  12. The lancet. A revolution in psychiatry. The Lancet. 2013; 381 (9881): p1878

  13. Joshi G, Wozniak J, Petty C, Martelon MK, Fried R, et al. Psychiatric co-morbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. J Autism Dev Disord. 2013; 43:1314–1325.

  14. Wu MS, Rudy BM, Storch EA. Obsessions, Compulsions, and Repetitive Behavior: Autism and/or OCD. In Handbook of Autism and Anxiety (pp. 107-120). Springer International Publishing; 2014.

  15. Jacob S, Landeros-Weisenberger A, Leckman JF. Autism spectrum and obsessivecompulsivedisorders: OC behaviors, phenotypes and genetics. Autism Res. 2009; 2(6): 293–311.

  16. Cadman T, Spain D, Johnston P, Russell A, Mataix‐Cols D, Craig M, et al. Obsessive‐Compulsive Disorder in Adults with High‐Functioning Autism Spectrum Disorder: What Does Self‐Report with the OCI‐R Tell Us?.Autism Res. 2015;doi: 10.1002/aur.1461.

  17. Bodfish JW, Symons FJ, Parker DE, Lewis MH. Varieties of repetitive behavior in autism: Comparisons to mental retardation. J Autism Dev Disord.2000; 30(3): 237-243.

  18. Oberhauser O. EndNote X7–Bibliographies Made Easy™(= Version 17). Carlsbad, CA: Thomson Reuters, 2013. Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare. 2014; 67(1): 174-178.

  19. Moher D, Liberati A, Tetzlaff J, AltmanDG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009; 151(4): 264-269.

  20. Martínez-González AE,Piqueras JA. Actualización neuropsicológica del trastorno obsesivo compulsivo. Rev Neurol. 2008;4:618-625.

  21. Martínez-González AE, Piqueras JA. Eficacia de la terapia cognitivo-conductual en trastornos de ansiedad y estado de ánimo mediante neuroimagen funcional. Rev Neurol. 2010; 50:167-178.

  22. Armstrong T, Sarawgi S, Olatunji BO. Attentional bias toward threat in contamination fear: Overt components and behavioral correlates. J Abnorm Psychol. 2012; 121(1): 232-237.

  23. Endrass T, Riesel A, Kathmann N, Buhlmann U. Performance monitoring in obsessive–compulsive disorder and social anxiety disorder. J Abnorm Psychol. 2014; 123(4): 705-714.

  24. McGuire JF, Crawford EA, Park JM, Storch EA, Murphy TK, Larson MJ, Lewin AB. Neuropsychological performance across symptom dimensions in pediatric obsessive compulsive disorder. Depress Anxiety. 2014; 31(12): 988–996.

  25. Najmi S, Amir N. The effect of attention training on a behavioral test of contamination fears in individuals with subclinical obsessive-compulsive symptoms. J Abnorm Psychol. 2010; 119(1): 136- 142.

  26. Shin NY, Kang DH, Choi JS, Jung MH, Jang JH, Kwon JS. Do organizational strategies mediate nonverbal memory impairment in drug-naïve patients with obsessive-compulsive disorder?. Neuropsychology. 2010; 24(4): 527-533.

  27. Vandborg SK, Hartmann TB, Bennedsen BE, Pedersen AD, Thomsen PH. Memory and executive functions in patients with obsessive-compulsive disorder.Cogn Behav Neurol. 2014; 27: 8-16.

  28. Endrass T, Koehne S, Riesel A, Kathmann N. Neural correlates of feedback processing in obsessive– compulsive disorder. J Abnorm Psychol. 2013; 122(2), 387-396.

  29. Endrass T, Ullsperger M. Specificity of performance monitoring changes in obsessive-compulsive disorder. Neurosci Biobehav Rev. 2014; 46(1): 124–138.

  30. Abramovitch A, Abramowitz JS, Mittelman A.The neuropsychology of adult obsessive–compulsive disorder: A meta-analysis. Clin psychol rev. 2013; 33(8): 1163-1171.

  31. Zhu C, YuF, Ye R, Chen X, Dong Y, Li D,et al. External error monitoring in subclinical obsessivecompulsive subjects: Electrophysiological Evidence from a Gambling Task. PloS one. 2014; 9(3): e90874.

  32. Lewin AB, Larson MJ, Park JM, McGuire JF, Murphy TK, Storch EA. Neuropsychological functioning in youth with obsessive compulsive disorder: An examination of executive function and memory impairment. Psychiatry Res. 2014; 30 (216):108-115.

  33. Wright L, Lipszyc J, Dupuis A, Thayapararajah SW, Schachar R. Response inhibition and psychopathology: A meta-analysis of go/no-go task performance. J Abnorm Psychol. 2014; 123(2): 429-439.

  34. Vara AS, Pang EW, Doyle-Thomas KA, Vidal J, Taylor MJ, Anagnostou E. Is inhibitory control a ‘nogo’in adolescents with autism spectrum disorder?. Mol Autism. 2014; 5(1): 6.doi:10.1186/2040- 2392-5-6.

  35. Wilson CE, Happé F, Wheelwright SJ, Ecker C, Lombardo MV, Johnston P, et al. The Neuropsychology of Male Adults With High‐Functioning Autism or Asperger Syndrome. Autism Res. 2014; 7 (5): 568–581.

  36. Yerys BE, Kenworthy L, Jankowski KF, Strang J, Wallace GL. Separate components of emotional go/no-go performance relate to autism versus attention symptoms in children with autism. Neuropsychology. 2013; 27(5): 537-545.

  37. Kenworthy L, Yerys BE, Weinblatt R, Abrams DN, Wallace GL. Motor demands impact speed of information processing in autism spectrum disorders. Neuropsychology. 2013; 27(5): 529-536.

  38. Jiang YV, Capistrano CG, Esler AN, Swallow KM. Directing attention based on incidental learning in children with autism spectrum disorder. Neuropsychology. 2013. 27(2), 161-169.

  39. Roser ME, Aslin RN, McKenzie R, Zahra D, Fiser J. Enhanced visual statistical learning in adults with autism.Neuropsychology. 2015; 29(2):163-72.

  40. Swettenham J, Remington A, Murphy P, Feuerstein M, Grim K, Lavie N. Seeing the Unseen: Autism Involves Reduced Susceptibility to Inattentional Blindness.Neuropsychology. 2014; 28(4): 563-570.

  41. Lind SE, Williams DM, Bowler DM, Peel A. Episodic memory and episodic future thinking impairments in high-functioning autism spectrum disorder: An underlying difficulty with scene construction or self-projection?. Neuropsychology. 2014;28(1): 55-67.

  42. Southwick JS, Bigler ED, Froehlich A, DuBray MB, Alexander AL, Lange N, Lainhart J. E. Memory functioning in children and adolescents with autism. Neuropsychology. 2011; 25(6): 702-710.

  43. Wojcik DZ, Moulin CJ, Souchay C. Metamemory in children with autism: Exploring “feeling-ofknowing” in episodic and semantic memory. Neuropsychology. 2013; 27(1): 19-27.

  44. Williams DM, Jarrold C, Grainger C, Lind SE. Diminished time-based, but undiminished event-based, prospective memory among intellectually high-functioning adults with autism spectrum disorder: relation to working memory ability. Neuropsychology. 2014; 28(1): 30-42.

  45. Vogan VM, Morgan BR, Lee W, Powell TL, Smith ML, Taylor MJ. The neural correlates of visuospatial working memory in children with autism spectrum disorder: effects of cognitive load. J Neuro dev Disord. 2014; 6(1): 1-15.

  46. Mammarella IC, Giofrè D, Caviola S, Cornoldi C, Hamilton C. Visuospatial working memory in children with autism: The effect of a semantic global organization. Res Dev Disabil. 2014; 35(6): 1349-1356.

  47. Erviti M, Semal C, Wright BA, Amestoy A, Bouvard MP, Demany L. A late-emerging auditory deficit in autism.Neuropsychology. 2014; 15: http://dx.doi.org/10.1037/neu0000162.

  48. Christ SE, Kanne SM, Reiersen AM. Executive function in individuals with subthreshold autism traits. Neuropsychology. 2010; 24(5): 590.

  49. Christ SE, Kester LE, Bodner KE, Miles JH. Evidence for selective inhibitory impairment in individuals with autism spectrum disorder. Neuropsychology. 2011; 25(6): 690.

  50. Rosenthal M, Wallace GL, Lawson R, Wills MC, Dixon E, Yerys BE, Kenworthy L. Impairments in real-world executive function increase from childhood to adolescence in autism spectrum disorders. Neuropsychology. 2013; 27(1): 13-18.

  51. White SJ. The triple I hypothesis: Taking another’s perspective on executive dysfunction in autism. J Autism Dev Disord. 2013; 43: 114–121.

  52. South M, Chamberlain PD, Wigham S, Newton T, Le Couteur A, McConachie H, et al. Enhanced decision making and risk avoidance in high-functioning autism spectrum disorder. Neuropsychology. 2014; 28(2): 222-228.

  53. Iidaka T. Resting state functional magnetic resonance imaging and neural network classified autism and control. Cortex. 2015; 63: 55-67.

  54. Weber AM, Soreni N, Stanley JA, Greco A, Mendlowitz S, Szatmari P, et al. Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder. Psychiat Res-Neuroim. 2014; 222: 67-74.

  55. Wen SL, Cheng MF, Cheng MH, Yue JH, Li JF, Xie LJ. Neurocognitive dysfunction and regional cerebral blood flow in medically naïve patients with Obsessive-Compulsive Disorder. Dev Neuropsychol. 2014; 39: 37-50.

  56. Brennan BP, Rauch SL, Jensen JE, Pope Jr HG. A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder. Biol Psychiatry. 2013; 73(1): 24-31.

  57. de la Vega DC, Ibaez Cuadrado A, Saiz Ruiz J. 2698–Interhemispheric asymmetry in OCD patients an study using non linear analysis of MEG recordings. Eur Psychiatry. 2013; 28: 1-1.

  58. Korostenskaja M, Harris E, Giovanetti C, Horn P, Wang Y, Rose D, et al. Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder. Psychiat Res-Neuroim. 2013; 212: 132-140.

  59. Alvarenga PG, do Rosário MC, Batistuzzo MC, Diniz JB, Shavitt RG, Duran FL, et al. Obsessivecompulsive symptom dimensions correlate to specific gray matter volumes in treatment-naïve patients. J Psychiatr Res. 2012; 46(12): 1635-1642.

  60. Harrison BJ, Pujol J, Cardoner N, Deus J, Alonso P, López-Solà M, et al. Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol Psychiatry. 2013; 73(4): 321-328.

  61. Radua J, Grau M, van den Heuvel OA, de Schotten MT, Stein DJ, Canales-Rodríguez, EJ, et al. Multimodal voxel-based meta-analysis of white matter abnormalities in Obsessive–Compulsive Disorder. Neuropsychopharmacology. 2014; 39(7): 1547-1557.

  62. Beucke JC, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, et al. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA psychiatry.2013;70(6): 619-629.

  63. Chien HY, Gau SSF, HsuYC, Chen YJ, Lo YC, ShihYC, TsengWYI. Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder. AutismResearch. 2015; Doi: 10.1002/aur.1484

  64. Cauda F, Costa T, Palermo S, D’Agata F, Diano M, Bianco F, et al. Concordance of white matter and gray matter abnormalities in autism spectrum disorders: A voxel‐based meta‐analysis study. Hum Brain Mapp. 2014; 35(5): 2073-2098.

  65. Aoki Y, Cortese S, Tansella M. Neural bases of atypical emotional face processing in autism: A metaanalysis of fMRI studies. World j biolpsychiatry. 2014; 29: 1-10.

  66. Allely CS, Gillberg C, Wilson P. Neurobiological abnormalities in the first few years of life in individuals later diagnosed with autism spectrum disorder: a review of recent data. Behav neurol.2014; Article ID 210780: 1-20.

  67. Skefos J, Cummings C, Enzer K, Holiday J, Weed K, Levy E, et al. Regional alterations in purkinje cell density in patients with Autism. PloS one. 2014; 9(2): e81255.

  68. Wang SSH, Kloth AD, Badura A. The cerebellum, sensitive periods, and autism. Neuron. 2014; 83(3): 518-532.

  69. Edalatmanesh MA, Nikfarjam H, Vafaee F, Moghadas M. Increased hippocampal cell density and enhanced spatial memory in the valproic acid rat model of autism. Brain Res. 2013; 1526: 15-25.

  70. Maister L, Simons JS, Plaisted-Grant K. Executive functions are employed to process episodic and relational memories in children with autism spectrum disorders. Neuropsychology. 2013; 27(6): 615-627.

  71. Barnea-Goraly N, Frazier TW, Piacenza L, Minshew NJ, Keshavan MS, Reiss AL, Hardan AY. A preliminary longitudinal volumetric MRI study of amygdala and hippocampal volumes in autism. Prog Neuropsychopharmacol Biol Psychiatry. 2014; 48: 124-128.

  72. Di Martino A, Yan CG, Li Q, Denio E, Castellanos FX, Alaerts K, et al. The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Mol Psychiatry. 2014; 19(6): 659-667.

  73. Zürcher NR, Bhanot A, McDougle CJ, Hooker JM. A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: Current state and future research opportunities. Neurosci Biobehav Rev.2015; doi:10.1016/j.neubiorev.2015.02.002.




2020     |     www.medigraphic.com