2016, Número 1
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Residente 2016; 11 (1)
Enfermedad aterosclerótica coronaria en artritis reumatoide
Olvera-Palafox CN, Flores-Chávez A, Romero-Moreno JR, Cardona-Müller D, Trujillo-Trujillo X, González-López L
Idioma: Español
Referencias bibliográficas: 50
Paginas: 19-27
Archivo PDF: 248.44 Kb.
RESUMEN
En el mecanismo de la aterosclerosis subclínica en pacientes con AR, se ha descrito la influencia tanto de la presencia de factores de riesgo tradicionales como el proceso inflamatorio y los mecanismos autoinmunes. Los autoanticuerpos, los autoantígenos, citocinas proinflamatorias y agentes infecciosos juegan un importante papel en este proceso. En la AR, se ha observado un incremento en la incidencia de la aterosclerosis acelerada; en pacientes con AR, la función vascular se encuentra alterada y el proceso de aterosclerosis parece estar acelerado debido a diversos factores, como el incremento de la rigidez arterial, las reducciones de la elasticidad arterial, el deterioro en la respuesta endotelial, el incremento del grosor de la íntima-media y el contenido de calcio coronario, los cuales se ven modificados debido a la presencia de la inflamación severa presente en estos sujetos y, a su vez, representan un incremento en el riesgo de morbilidad y mortalidad cardiovascular.
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