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2003, Número 4

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Rev Inst Nal Enf Resp Mex 2003; 16 (4)


Microquimerismo y enfermedades humanas

Bustos EML

Idioma: Español
Referencias bibliográficas: 53
Paginas: 261-270
Archivo PDF: 89.03 Kb.


RESUMEN

Se conoce como quimerismo al fenómeno en el cual un individuo porta células de otro, y microquimerismo a los bajos niveles de quimerismo. La enfermedad injerto-versus-huésped es un proceso patológico en que el paciente presenta quimerismo, y comparte características clínicas con algunas enfermedades autoinmunes como la esclerosis sistémica progresiva, la cirrosis biliar primaria y el síndrome de Sjögren. Estos antecedentes dieron origen a la hipótesis de que las células microquiméricas podrían desempeñar un papel en la patogénesis de dichas enfermedades autoinmunes. Durante los últimos años se ha reportado la persistencia de células fetales en la madre, así como la presencia de células maternas en el hijo, aunque las investigaciones realizadas para dilucidar su posible relación con enfermedades autoinmunes han dado resultados contradictorios.


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