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TIP Revista Especializada en Ciencias Químico-Biológicas

2015, Número 2

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TIP Rev Esp Cienc Quim Biol 2015; 18 (2)


Infertilidad masculina y fragmentación del ADN espermático: Un problema actual

Quintero–Vásquez GA, Bermúdez-Cruz RM, Castillo-Cadena J

Idioma: Español
Referencias bibliográficas: 87
Paginas: 144-151
Archivo PDF: 741.38 Kb.


RESUMEN

El ADN del espermatozoide aporta la mitad del material genético a la descendencia, en la actualidad los parámetros obtenidos a través de un seminograma no dan una información completa sobre el potencial fecundante del semen y la capacidad de dar lugar a un embrión sano y un embarazo evolutivo. Es por ésto que ha aumentado el interés en desarrollar técnicas encaminadas a evaluar la fragmentación del ADN espermático, ya que en cualquier etapa del proceso de la espermatogénesis se puede producir un daño, siendo éste un fenómeno multifactorial y no del todo delimitado. Actualmente la infertilidad es un problema global que va en aumento y se ha demostrado que la calidad del ADN del espermatozoide puede afectar la fecundación; es por ello que la evaluación de la integridad del ADN, además del estudio de los parámetros seminales, puede aportar información adicional acerca de la calidad del espermatozoide, y ser de gran ayuda para identificar las causas de la infertilidad masculina y así orientar de mejor manera a las parejas.


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