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TIP Revista Especializada en Ciencias Químico-Biológicas

2014, Número 2

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TIP Rev Esp Cienc Quim Biol 2014; 17 (2)


ArcB: El sensor del estado redox en bacterias

Núñez-Oreza LA, Georgellis D, Álvarez AF

Idioma: Español
Referencias bibliográficas: 55
Paginas: 135-146
Archivo PDF: 649.01 Kb.


RESUMEN

El sistema de dos componentes Arc está compuesto por la cinasa sensora ArcB y por el regulador de respuesta ArcA. En Escherichia coli, este sistema regula la red transcripcional implicada en el metabolismo energético, acorde a las condiciones de óxido-reducción del medio. En condiciones anóxicas de crecimiento, ArcB se autofosforila y transfosforila a ArcA, el cual reprime o activa la expresión de sus operones blanco. En condiciones aeróbicas, ArcB actúa como una fosfatasa, catalizando la defosforilación de ArcA-P e inactivándolo como regulador transcripcional. Esta revisión describe las principales propiedades estructurales de ArcB y los eventos trascendentales que ocurren en la señalización por Arc, incluyendo la percepción de la señal y la regulación de la actividad cinasa. Además, compara la secuencia de ArcB de E. coli con la de homólogos en otras bacterias, revelando similitudes y diferencias que pueden ser de gran importancia en la regulación de esta proteína sensora.


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