2014, Número 4
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Rev cubana med 2014; 53 (4)
Asociación entre hepatitis crónica por virus C y linfoma no Hodgkin de células B
Dorta GZ, Arús SER, Calzadilla BL
Idioma: Español
Referencias bibliográficas: 50
Paginas: 468-477
Archivo PDF: 89.72 Kb.
RESUMEN
Se estima que unos 170 millones de personas están infectadas por el virus de la
hepatitis C (VHC) en todo el mundo. La persistencia del virus en el organismo es
consecuencia de su capacidad de mutar y de las alteraciones en la respuesta
inmunológica que produce. Existen teorías que relacionan este virus con la
linfomagénesis. El riesgo relativo de que pacientes infectados con el VHC padezcan
linfoma no Hodgkin (LNH) es de 2 a 4 veces mayor que en los sujetos no
infectados. Esta asociación tiene variabilidad geográfica: los países donde esa
asociación es mayor son Italia, Japón y Estados Unidos, y donde es menor son
Canadá y los del norte de Europa. El linfoma de la zona marginal de células B y el
linfoplasmocitico son los más reportados en asociación con el VHC. Los LNH
indolentes asociados con el VHC pueden ser tratados con terapia antiviral, no así las
formas agresivas que necesitan de inmunoquimioterapia específica. Se ha
demostrado que la hepatitis C es un significativo factor de riesgo para la toxicidad
hepática en los pacientes que necesitan quimioterapia.
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