Jiménez-Flores LM, Flores-Pérez EC, Mares-Álvarez DP, Macías-Cervantes MH, Ramírez-Emiliano J, Pérez-Vázquez V

Idioma: Español
Referencias bibliográficas: 51
Paginas: 88-94
Archivo PDF: 229.04 Kb.

RESUMEN

La incidencia de la diabetes mellitus tipo 2 (DM2) está creciendo rápidamente debido al envejecimiento de la población, cambios en el estilo de vida e incremento en la prevalencia de la obesidad. En la DM2, la hiperglucemia crónica conlleva complicaciones macro- y microvasculares que en la actualidad son un problema grave para los sistemas de salud en todo el mundo. La DM2 es una enfermedad altamente heterogénea que requiere de técnicas de estudio de alto rendimiento que permitan obtener información sobre los mecanismos y vías biológicas que inducen a la enfermedad y sus complicaciones. En este trabajo describimos las aportaciones más recientes de la proteómica en el estudio de la diabetes y discutimos su importancia en la identificación de blancos terapéuticos y biomarcadores que podrían ayudar en el diagnóstico de la DM2, a monitorear la progresión de la enfermedad y al desarrollo de nuevos fármacos para mejorar las terapias y disminuir sus complicaciones.

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