Paulino R

Idioma: Español
Referencias bibliográficas: 26
Paginas: 145-148
Archivo PDF: 190.48 Kb.

RESUMEN

En la infección por VIH-1 el tropismo del mismo por los linfocitos T CD4+, la activación de Linfocitos B dependiente de T es retrasada de forma drástica. Entre un 10 - 30% de las personas que se infectan con VIH desarrollan actividad serológica con la habilidad de generar respuestas neutralizadoras contra algunos subtipos de VIH. A estos individuos capaces de generar una respuesta neutralizante se les conoce como controladores élite. Estos anticuerpos neutralizantes incluyen anticuerpos contra la región hipervariable de V3 en la glicoproteína gp 120, también conocido como anticuerpo 447-52D. Estos anticuerpos no han demostrado una alta potencia neutralizante pero sí de especificidad a las estructuras proteicas del virus. Los anticuerpos neutralizantes tienen como característica que son somáticamente mutables. A pesar del éxito de la inmunoterapia en situaciones de infecciones bacterianas y virales, los investigadores aún no han podido demostrar de manera eficaz que el uso de anticuerpos contra VIH-1 sea efectivo a largo plazo; esta incapacidad se fundamenta debido a que el VIH-1 tiene la capacidad de escape y cambios rápidos en su estructura molecular

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