Rodríguez-Franco DA, Vázquez-Moreno L, Ramos-Clamont MG

Idioma: Español
Referencias bibliográficas: 119
Paginas: 102-111
Archivo PDF: 180.85 Kb.

RESUMEN

La lactoferrina (Lf) es una glicoproteína multifuncional que presenta la capacidad de unir hierro. Una de las funciones primordiales de la Lf es el transporte de metales. También actúa como proteína de defensa no específica. La Lf se encuentra en diversas secreciones mucosas como la leche, las lágrimas y la saliva. También es un componente abundante de los neutrófilos y puede ser liberada al plasma sanguíneo por la acción de éstos. Las lactoferrinas humana y bovina, despliegan un amplio espectro antimicrobiano, actuando contra bacterias Gram positivas y Gram negativas y contra algunos virus y hongos. Inicialmente se pensó que esta actividad antimicrobiana se debía únicamente a su capacidad de secuestrar hierro. En la actualidad, se sabe que existen diversos mecanismos que contribuyen a la capacidad de esta glicoproteína, para defender a los mamíferos de las infecciones microbianas. Esta revisión presenta un panorama del conocimiento actual acerca de dichos mecanismos y de las aplicaciones clínicas potenciales de la Lf, contra infecciones microbianas.

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