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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2013, Número 6

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Rev Invest Clin 2013; 65 (6)


Seguridad de un sistema de fibra derivada del agave con potencial acción prebiótica incorporado a una fórmula infantil en recién nacidos de término

López-Velázquez G, Díaz-García L, Anzo A, Parra-Ortiz M, Llamosas-Gallardo B, Ortiz-Hernández AA, Mancilla-Ramírez J, Cruz-Rubio JM, Gutiérrez-Castrellón P

Idioma: Ingles.
Referencias bibliográficas: 40
Paginas: 483-490
Archivo PDF: 166.17 Kb.


RESUMEN

Justificación. Las fórmulas infantiles se han suplementado con probióticos, prebióticos o simbióticos, a pesar de que continúan existiendo dudas acerca de la seguridad y eficacia de los mismos. El agave mexicano es una fuente de fructanos con características particulares y con potencial efecto prebiótico. Material y métodos. Ensayo clínico controlado (RCT) realizado en 600 recién nacidos de término sanos (20 ± 7 días), aleatorizados a recibir una fórmula infantil estándar (control) o una fórmula adicionada con mezcla variable de prebióticos derivados del agave mexicano. Los desenlaces primarios fueron la frecuencia y consistencia de las evacuaciones, los datos de tolerancia gastrointestinal (distensión abdominal, flatulencia, regurgitaciones y vómito). Los desenlaces secundarios fueron la ganancia pondo-estatural y la frecuencia de eczema. Resultados. En el análisis de 66,120 días de seguimiento no se observaron diferencias en la frecuencia diaria de las evacuaciones (leche materna 3.8 ± 2.4 evacuaciones/día; Pro + Metlin + Metlos 3.6 ± 2.0; Pro + Metlin 3.6 ± 2; fórmula sólo con probióticos 3.4 ± 2.3 y sólo fórmula 3.4 ± 2.0; p NS). La consistencia de las evacuaciones fue similar entre los grupos de leche materna y quienes recibieron la mezcla de prebióticos. La frecuencia de manifestaciones gastrointestinales fueron significativamente menores en estos mismos grupos. Conclusiones. La adición de fructanos derivados del agave mexicano en las fórmulas infantiles es segura y bien tolerada por los recién nacidos sanos mexicanos.


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