2013, Número 6
<< Anterior Siguiente >>
Salud Mental 2013; 36 (6)
La especialización hemisférica y la regulación de la conducta motora desde la perspectiva de la neurociencia cognitiva
Machado S, Arias-Carrión Ó, Orellana CAV, Lattari E, Cardoso SA, Egídio NA
Idioma: Español
Referencias bibliográficas: 99
Paginas: 513-520
Archivo PDF: 210.81 Kb.
RESUMEN
Introducción
Nuestra comprensión de la organización funcional del cerebro se
debe a los avances en las técnicas de neuroimagen y a una intensa
investigación clínica. Recientemente, la ciencia cognitiva (neurociencia
cognitiva) en combinación con los avances tecnológicos han cambiado
nuestra comprensión sobre la relación cerebro-conducta. Esta
relación simbiótica ha permitido una mejor caracterización del sitio
de la lesión en pacientes con trastornos cerebrales y de los patrones
de activación en sujetos sanos.
Objetivo
En el presente artículo se discute la contribución del hemisferio izquierdo
y la participación del hemisferio derecho en la regulación de
la conducta motora; esto nos permitirá comprender mejor la lateralización
de las funciones motoras.
Desarrollo
Los resultados apoyan la visión de un predominio del hemisferio izquierdo
para el lenguaje y el control motor, y un predominio del hemisferio
derecho para las funciones espaciales y la atención. Las áreas especializadas
son probablemente predeterminadas y ciertas funciones
están lateralizadas a uno u otro hemisferio, esto debido a la eficiente
organización y procesamiento de la información en el cerebro.
Conclusión
En los estudios revisados, se observaron funciones específicas para
cada hemisferio, lo que sugiere la existencia de una compleja organización
que recluta a varias áreas del Sistema Nervioso para el
adecuado desempeño de una tarea.
REFERENCIAS (EN ESTE ARTÍCULO)
Haaland KY. Left hemisphere dominance for movement. Clin Neuropsychol 2006;20:609-622.
Matthews PM, Adcock J, Chen Y, Fu S et al. Towards understanding language organization in the brain using fMRI. Hum Brain Mapp 2003;18:239-247.
Serrien DJ, Brown P. The functional role of interhemispheric synchronization in the control of bimanual tasks. Exp Brain Res 2002;147:268-272.
Serrien DJ, Cassidy MJ, Brown P. The importence of the dominant hemisphere in the organization of bimanual movements. Hum Brain Mapp 2003;18:296-305.
Serrien DJ, Fisher RJ, Brown P. Transient increases of synchronized neural activity during movement preparation: influence of cognitive constraints. Exp Brain Res 2003;153:27-34.
Serrien DJ, Ivry RB, Swinnen SP. The missing link between action and cognition. Prog Neurobiol 2007;82:95-107.
Friston KJ. Models of brain function in neuroimaging. Ann Rev Psychol 2005;56:57-87.
Joanette Y, Ansaldo AI, Kahlaoui K, Côté H et al. Impacto de las lesiones del hemisferio derecho sobre las habilidades lingüísticas: perspectivas teórica y clínica. Rev Neurol 2008;46:481-488.
Goble DJ, Brown SH. The biological and behavioral basis of upper limb asymmetries in sensorimotor performance. Neurosci Biobehav Rev 2008;32:598-610.
Voets NL, Adcock JE, Flitney DE, Behrens TE et al. Distinct right frontal lobe activation in language processing following left hemisphere injury. Brain 2006;129:754-766.
Isaacs KL, Barr WB, Nelson PK, Devinsky O. Degree of handedness and cerebral dominance. Neurology 2006;66:1855-1858.
Sveller C, Briellmann RS, Saling MM, Lillywhite L et al. Relationship between language lateralization and handedness in left-hemispheric partial epilepsy. Neurology 2006;67:1813-1817.
Homae F, Watanabe H, Nakano T, Taga G. Prosodic processing in the developing brain. Neurosci Res 2007;59:29-39.
Pannekamp A, Weber C, Friederici AD. Prosodic processing at the sentence level in infants. Neuroreport 2006;17:675-178.
Vernooij MW, Smits M, Wielopolski PA, Houston GC et al. Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study. Neuroimage 2007;35:1064-1076.
Pascual A, Huang KL, Neveu J, Préat T. Neuroanatomy: brain asymmetry and long-term memory. Nature 2004;427:605-606.
Hatta T. Handedness and the brain: a review of brain-imaging techniques. Magn Reson Med Sci 2007;6:99-112.
Skipper JI, Goldin-Meadow S, Nusbaum HC, Small SL. Speech-associated gestures, Broca’s area, and the human mirror system. Brain Lang 2007;101:260-277.
Lausberg H, Zaidel E, Cruz RF, Ptito A. Speech-independent production of communicative gestures: evidence from patients with complete callosal disconnection. Neuropsychologia 2007;45:3092-3104.
Roy AC, Craighero L, Fabbri-Destro M, Fadiga L. Phonological and lexical motor facilitation during speech listening: a transcranial magnetic stimulation study. J Physiol Paris 2008;102:101-105.
Watkins K, Paus T. Modulation of motor excitability during speech perception: the role of Broca’s area. J Cogn Neurosci 2004;16:978-987.
Hauk O, Jonhsrude I, Pulvermüller F. Somatotopic representation of action words in the motor and premotor cortex. Neuron 2004;41:301-307.
Pulvermüller F, Hauk O, Nilkulin VV, Limoniemi RJ. Functional links between motor and language systems. Eur J Neurosci 2005;21:793-797.
Fabbri-Destro M, Rizzolatti G. Mirror neurons and mirror systems in monkeys and humans. Physiology (Bethesda) 2008;23:171-179.
Rizzolatti G, Fabbri-Destro M, Cattaneo L. Mirror neurons and their clinical relevance. Nat Clin Pract Neurol 2009;5:24-34.
Binkofski F, Buccino G. Motor functions of the Broca’s region. Brain Lang 2004;89:362-369.
Dominey PF, Hoen M, Blanc, JM, Lelekov-Boissard T. Neurological basis of language and sequential cognition: evidence from simulation, aphasia, and ERP studies. Brain Lang 2003;86:207-225.
Dominey PF, Inui T, Hoen M. Neural network processing of natural language: II. Towards a unified model of corticostriatal function in learning sentence comprehension and non-linguistic sequencing. Brain Lang 2008;109:80-92.
McGeoch PD, Ramachandran VS. Apraxia, metaphor and mirror neurons. Med Hypotheses 2007;69:1165–1168.
Harrington DL, Haaland KY. Hemispheric specialization for motor sequencing: Abnormalities in levels of programming. Neuropsychologia 1991;29:147–163.
Kimura D. Left-hemisphere control of oral and brachial movements and their relation to communication. Philos Trans R Soc Lond Biol Sci 1982;298:135–149.
Harrington DL, Rao SC, Haaland KY, Bobholz JA et al. Specialized neural systems underlying representation of sequential movements. J Cogn Neurosci 2000;12:56–77.
Amunts K, Schleicher A, Zilles, K. Cytoarchitecture of the cerebral cortex-more than localization. Neuroimage 2007;37:1061-1065.
Hammond G. Correlates of human handedness in primary motor cortex: a review and hypothesis. Neurosci Biobehav Rev 2002;26:285-92.
Gross RG, Grossman M. Update on apraxia. Curr Neurol Neurosci Rep 2008;8:490-496.
Haaland KY, Elsinger CL, Mayer AR, Durgerian S et al. Motor sequence complexity and performing hand produce differential patterns of hemispheric lateralization. J Cogn Neurosci 2004;16:621-636.
Haaland KY, Prestopnick JL, Knigth RT, Lee RR. Hemispheric asymmetries for kinematic and positional aspects of reaching. Brain 2004;127:1145-1158.
Schaefer SY, Haaland KY, Sainburg RL. Ipsilesional motor deficits following stroke reflect hemispheric specializations for movement control. Brain 2007;130:2146-2158.
Rinehart JK, Singleton RD, Adair JC, Sadek JR et al. Arm use after left or right hemiparesis is influenced by hand preference. Stroke 2009;40:545-550.
Vines BW, Nair D, Schlaug G. Modulating activity in the motor cortex affects performance for the two hands differently depending upon which hemisphere is stimulated. Eur J Neurosci 2008;28:1667-1673.
Guye M, Bartolomei F, Ranjeva JP. Imaging structural and functional connectivity: towards a unified definition of human brain organization? Curr Opin Neurol 2008;21:393-403.
Müller-Dahlhaus JF, Orekhov Y, Liu Y, Ziemann U. Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation. Exp Brain Res 2008;187:467-475.
Rushworth MF, Taylor PC. TMS in the parietal cortex: updating representations for attention and action. Neuropsychologia 2006;44:2700-2716.
Carboni-Roman A, Del Rio Grande D, Capilla A, Maestu F et al. Bases neurobiológicas de las dificultades de aprendizaje. Rev Neurol 2006;42:S171-S175.
Jax SA, Coslett HB. Disorders of the perceptual-motor system. Adv Exp Med Biol 2009;629:377-391.
O’Shea J, Sebastian C, Boorman ED, Johansen-Berg H et al. Functional specificity of human premotor-motor cortical interactions during action selection. Eur J Neurosci 2007;26:2085-2095.
Króliczak G, Frey SH. A Common network in the left cerebral hemisphere represents planning of tool use pantomimes and familiar intransitive gestures at the hand-independent level. Cereb Cortex 2009;19:2396-2410.
Aramaki Y, Honda M, Sadato N. Suppression of the non-dominant motor cortex during bimanual symmetric finger movement: a functional magnetic resonance imaging study. Neuroscience 2006;141:2147-2153.
Cincotta M, Ziemann U. Neurophysiology of unimanual motor control and mirror movements. Clin Neurophysiol 2008;119:744-762.
Seitz RJ, Franz M, Azari NP. Value judgments and self-control of action: The role of the medial frontal cortex. Brain Res Rev 2009;60:368-378.
Wu X, Chen K, Liu Y, Long Z et al. Ipsilateral brain deactivation specific to the nondominant hand during simple finger movements. Neuroreport 2008;19:483-486.
Hickok G, Bellugi U, Klima ES. The neurobiology of sign language and its implications for the neural basis of language. Nature 2002;381:699-702.
Hickok G, Poeppel D. The cortical organization of speech processing. Nat Rev Neurosci 2007;8:393-402.
Martin JH, Friel KM, Salimi I, Chakrabarty S. Activity- and use-dependent plasticity of the developing corticospinal system. Neurosci Biobehav Rev 2007;31:1125-1135.
Mars RB, Piekema C, Coles MG, Hulstijn W et al. On the programming and reprogramming of actions. Cereb Cortex 2007;17:2972-2979.
Machado S, Cunha M, Portella CE, Silva JG et al. Integration of cortical areas during performance of a catching ball task. Neurosci Lett 2008;446:7-10.
Chase C, Seidler R. Degree of handedness affects intermanual transfer of skill learning. Exp Brain Res 2008;190:317-328.
Rossini PM, Dal Forno G. Integrated technology for evaluation of brain function and neural plasticity. Phys Med Rehab Clin North Am 2004;15:263-306.
Shabbott BA, Sainburg RL. Differentiating between two models of motor lateralization. J Neurophysiol 2008;100:565-575.
Corballis PM. Visuospatial processing and the right-hemisphere interpreter. Brain Cogn 2003;53:171-176.
Mesulam MM. Spatial attention and neglect: parietal, frontal and cingulated contributions to the mental representation and attentional targeting of salient extrapersonal events. Philos Trans R Soc Lond Biol Sci 1999;354:1325-1346.
Macaluso E, Cherubini A, Sabatini U. Bimanual passive movement: functional activation and inter-regional coupling. Front Integr Neurosci 2007;1:5.
Machado S, Cunha M, Portella CE, Silva JG et al. Participación de la corteza parietooccipital en el proceso de integración sensoriomotora: estudio electroencefalográfico. Rev Neurol 2008;47:146-149.
Verstynen TD, Dieedrichsen J, Albert N, Aparicio P et al. Ipsilateral motor cortex activity during unimanual hand movements relates to task complexity. J Neurophysiol 2005;93:1209-1222.
Sainburg RL. Evidence for a dynamic-dominance hypotesis of handedness. Exp Brain Res 2002;142:241-258.
Sun FT, Miller LM, D’esposito M. Measuring temporal dynamics of functional networks using phases spectrum of MRI data. Neuroimage 2005;28:227-237.
Halsband U, Lange RK. Motor learning in man: a review of functional and clinical studies. J Physiol Paris 2006;99:414-424.
Goldberg E, Podell K, Loveli M. Lateralization of frontal lobe functions and cognitive novelty. J Neuropsychiatry Clin Neurosci 1994;6:371-378.
Himmelbach M, Karnath HQ. Goal-directed hand movements are not affected by the biasesd space representation in spatial neglect. J Cogn Neurosci 2003;15:972-980.
Debare F, Wenderoth N, Sunaert S, van Hecke P et al. Changes in brain activation during the acquisition of a new bimanual coordination task. Neuropsychologia 2004;42:855-867.
Rossini PM, Altamura C, Ferreri F, Melgari JM et al. Neuroimaging experimental studies on brain plasticity in recovery from stroke. Eura Medicophys 2007;43:241-254.
Esparza DY, Archambault PS, Winstein CJ, Levin MF. Hemispheric specialization in the co-ordination of arm and trunk movements during pointing in patients with unilateral brain damage. Exp Brain Res 2003;148:488-497.
Johansen-Berg H, Matthews PM. Attention to movement modulates activity in sensorimotor areas, including primary motor cortex. Exp Brain Res 2007;142:13-24.
Abbruzzese G, Berardelli A. Sensorimotor integration in movement disorders. Mov Disorders 2003;18:231-240.
Zeuner KE, Molloy FM. Abnormal reorganization in focal hand dystonia- sensory and motor training programs to retrain cortical function. NeuroRehabilitation 2008;23:43-53.
Werhahn KJ, Mortensen J, Van Boven RW, Zeuner KE et al. Enhanced tactile spatial acuity and cortical processing during acute hand deafferentation. Nat Neurosci 2002;5:936–938.
Maki Y, Wong KF, Sugiura M, Ozaki T et al. Asymmetric control mechanisms of bimanual coordination: an application of directed connectivity analysis to kinematic and functional MRI data. Neuroimage 2008;42:1295-1304.
Duque J, Mazzocchio R, Dambrosia J, Murase N et al. Kinematically specific interhemispheric inhibition operanting in the process of generation of a voluntary movement. Cereb Cortex 2005;15:588-593.
De Gennaro L, Cristiani R, Bertini M, Curcio G et al. Handedness is mainly associated with an asymmetry of corticospinal excitability and not of transcallosal inhibition. Clin Neurophysiol 2004;115:1305-1312.
Garvey MA, Mall V. Transcranial magnetic stimulation in children. Clin Neurophysiol 2008;119:973-984.
Derakhshan I. Laterality of motor control revisited: directionality of callosal traffic and its rehabilitative implications. Top Stroke Rehabil 2005;12:76-82
Cardoso de Oliveira S, Gribova A, Donchin O, Bergman H et al. Neural interactions between motor cortical hemispheres during bimanual and unimanual arm movements. Eur J Neurosci 2001;14:1881-1896.
Obhi SS, Goodale MA. Bimanual interference in rapid discrete movements is task specific and occurs at multiple levels of processing. J Neurophysiol 2005;94:1861-1868.
Maslovat D, Carlsen AN, Ishimoto R, Chua R et al. Response preparation changes following practice of an asymmetrical bimanual movement. Exp Brain Res 2008;190:239-249.
Sternad D, Wei K, Diedrichsen J, Ivry RB. Intermanual interactions during initiation and production of rhythmic and discrete movements in individuals lacking a corpus callosum. Exp Brain Res 2007;176:559-574.
Varela F, Lachaux JP, Rodríguez E, Martinerie J. The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2001;2:229-239.
Sporns O, Chialvo DR, Kaiser M, Hilgetag CC. Organization, development and function of complex brain networks. Trends Cogn Sci 2004;8:418-425.
Ioannides AA. Dynamic functional connectivity. Curr Opin Neurobiol 2007;17:161-170.
Brovelli A, Ding M, Ledberg A, Chen Y et al. Beta oscillations in a large- scale sensorimotor cortical network: directional influences revealed by Granger causality. Proc Nat Acad Sci USA 2004;101:9849-9854.
Zhang Y, Chen Y, Bressler SL, Ding M. Response preparation and inhibition: the role of the cortical sensorimotor beta rhythm. Neuroscience 2008;156:238-246.
Fries P. A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci 2005;9:474-480.
Kranczioch C, Athanassiou S, Shen S, Gao G et al. Short-term learning of a visually guided power-grip task is associated with dynamic changes in EEG oscillatory activity. Clin Neurophysiol 2008;119:1419-1430.
Hummel F, Gerloff C. Larger interregional synchrony is associated with greater behavioral success in a complex sensory integration task in humans. Cereb Cortex 2005;15:670-678.
Andres FG, Mima T, Schulman AE, Dichgans J et al. Functional coupling of human cortical sensorimotor areas during bimanual skill acquisition. Brain 1999;122:855-870.
Sarter M, Berntson GG, Cacioppo JT. Brain imaging and cognitive neuroscience. Toward strong inference in attributing function to structure. Am Psychol 1996;51:13–21.
Iacoboni M, Dapretto M. The mirror neuron system and the consequences of its dysfunction. Nat Rev Neurosci 2006;7:942-951.
Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? Neuropsychol Rev 2005;15:59-71.
Gisiger T, Kerszberg M. From a representation of behavior to the concept of cognitive syntax: a theoretical framework. Prog Brain Res 2007;165:463-474.
Iacoboni M, Zaidel E. Interhemispheric visuo-motor integration in humans: the role of the superior parietal cortex. Neuropsychologia 2004;42:419-425.