Soria FC, Pérez VMI, Flores SME, Feria VAI

Idioma: Español
Referencias bibliográficas: 53
Paginas: 480-489
Archivo PDF: 98.34 Kb.

RESUMEN

El propósito de este trabajo fue recapitular e integrar información disponible de diferentes estudios sobre la participación de la serotonina (5-HT) en la modulación de la conducta agresiva. A la 5-HT se le ha implicado en la modulación de la agresión de diversas especies de animales, incluyendo a los humanos. En el sistema nervioso central (SNC) el sistema serotoninérgico tiene interacciones complejas con varias moléculas neurotransmisoras en el cerebro. Su localización, distribución y diversidad de receptores hacen de éste un sistema interesante en muchos de los aspectos conductuales básicos, tales como: ingesta de agua y alimento, la conducta sexual y la agresión. A pesar de las investigaciones en el supuesto papel de la 5-HT en la agresión, no existen datos claros acerca de su papel específico. El empleo de agonistas y/o antagonistas selectivos para ciertos subtipos de receptores a la 5-HT parece ser una de las aproximaciones más comprometedoras en el entendimiento de la 5-HT en la agresión. De los 14 tipos de receptores a la 5-HT, el 5-HT1B (posináptico) y en un menor grado el receptor 5-HT1A parece desempeñar un papel importante en la modulación de la agresión (ofensiva) al menos en roedores.

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