2013, Número 2
<< Anterior Siguiente >>
Perinatol Reprod Hum 2013; 27 (2)
Tumor phyllodes
Jiménez-López J, Márquez-Acosta G, Olaya GEJ, Gómez-Pue D, Arteaga GAC
Idioma: Español
Referencias bibliográficas: 55
Paginas: 106-112
Archivo PDF: 458.98 Kb.
RESUMEN
El tumor
phyllodes es una neoplasia fibroepitelial rara; constituye el 0.3 al 0.9% de tumores de mama y 2-3% de los tumores fibroepiteliales de mama. Puede presentarse a cualquier edad y no hay características confiables para predecir su comportamiento clínico. Se deben evaluar varios parámetros, incluyendo la celularidad estromal, atipia, mitosis, crecimiento estromal excesivo, infiltración de bordes y presencia o ausencia de necrosis. La mayor parte de estos tumores son benignos, pero hasta 30% pueden presentar tejido conectivo maligno. Las metástasis generalmente son hematógenas más que linfáticas y se presentan en un 13% de los casos. La disección de ganglios axilares generalmente no se recomienda. El tumor
phyllodes benigno y maligno recurre de manera local en el 25%, por lo que se recomienda el seguimiento de los casos.
REFERENCIAS (EN ESTE ARTÍCULO)
Rowell MD, Perry RR, Hsiu JG, Barranco SC. Phyllodes Tumors. Am J Surgery. 1993; 165: 376-9.
Guray M, Sahin A. Benign breast diseases: classification, diagnosis, and management. The Oncologist. 2006; 11: 435-49.
Chen W, Cheng S, Tzen C, Yang T, Jeng K, Liu C et al. Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. J Surg Oncol. 2005; 91: 185-94.
August D, Kearney T. Cystosarcoma phyllodes: mastectomy, lumpectomy, or lumpectomy plus irradiation. Surgical Oncology. 2000; 9: 49-52.
Guerrero M, Ballard B, Grau A. Malignant phyllodes tumor of the breast review of the literature: and case report of stromal overgrowth. Surgical Oncology. 2003; 12: 27-37.
Salvadori B, Cusumano F, Del Bo R, Delledonne V, Grassi M, Rovini D. Surgical treatment of phyllodes tumors of the breast. Cancer. 1989; 63: 2532-6.
Reinfus M, Mitus J, Duda K, Stelmach A, Rys J, Smolak K. The treatment and prognosis of patients with phyllodes tumor of the breast. Cancer. 1996; 77: 910-6.
World Health Organization. Histologic typing of breast tumors, vol. 2. 2nd ed. Geneve Switzerland: Healt Organization; 1981: 22.
Parker S, Harries S. Phyllodes tumours. Review. Postgrad Med J. 2001; 77: 428-35.
Buchanan E. Cystosarcoma phyllodes and its surgical management. Am Surg. 1995; 61: 350-5.
Mangi A, Smith B, Gadd M, Tanabe K, Ott M, Souba W. Surgical management of phyllodes tumors. Arch Surg. 1999; 134: 487-93.
Bernstein L, Deapen D, Ross R. The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast. Cancer. 1993; 71: 3020-4.
Adachi Y, Matsushima T, Kido A. Phyllodes tumor in adolescents. Report of two cases and review of the literatura. Breast Dis. 1993; 6: 285-293.
Vorherr H, Vorherr U, Kutvirt D, Kay C. Cystosarcoma phyllodes. Epidemiology, pathohistology, pathobiology, diagnosis, therapy and survival. Arch Gynecol. 1985; 236: 173-81.
Keelan P, Myers J, Wold L, Katzmann J. Phyllodes tumours: clinicopathologic review of 60 patients and floor citometric analysis in 30 patients. Hum Pathol. 1992; 23: 1048-54.
Rajan P, Cranor M, Rosen P. Cystosarcoma phyllodes in adolescent girls, young women. Am J Surg Pathol. 1998; 229: 64-9.
Pantoja E, Llobert R, Lopez E. Gigant cystosarcoma phyllodes in a man with gynecomastia. Arch Surg. 1976; 111: 611-9.
Lindquist KD, van Heerden JA, Weiland LH, Martin JK. Recurrent and metastatic cystosarcoma phyllodes. Am J Surg. 1982; 144: 341-3.
Kapiris I, Nasiri N, A’Hern R, Healy V. Outcome and predictive factors local recurrence and distant metastases following primary surgical treatment of high-grade malignant phyllodes tumours of the breast. EJSO. 2001; 27: 723-30.
Carter B, Page D. Phyllodes tumor of the breast: local recurrence versus metastatic capacity. Hum Pathol. 2004; 35: 1051-2.
Pandey M, Mathew A, Kattoor J, Abraham E, Mathew B, Rajan B. Malignant Phyllodes Tumor. Breast J. 2001; 7: 411-6.
Kario K, Maeda S, Mizuno Y, Tankawa H, Kitazawa S. Phyllodes tumor of the breast: a clinicopathologic study of 34 cases. J Surg Oncol. 1990; 45: 46-51.
Moffat C, Pinder S, Dixon A, Elston C, Blamey M, Ellis I. Phyllodes tumors of the breast: a clinicopathological review of 32 cases. Histopathology. 1995; 27: 205-18.
Birdsall S, Summershill B, Egan M, Fentiman I, Gusterson B, Shipley J. Additional copies of 1q in sequential samples from a phyllodes tumor of the breast. Can Gen Cytogen. 1995; 83: 111-4.
Atherton A, Monaghan P, Warburton MJ, Robertson D, Kenny AF, Gudterson BA. Dipeptidyl peptidase IV expression identifies functional sub-population of breast fibroblasts. Int J Cancer. 1992; 50: 15-9.
Aranda FI, Laforga JB, Lopez JL. Phyllodes tumor of the breast. An immunohistochemical study of 28 cases with special attention to the role of myofibroblast. Pathol Res Pract. 1994; 190: 474-81.
Satou T, Matsunami N, Fujiki C, Tanaka K, Hayashi, Hashimoto S. Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation. Diagnostic. Cytopathology. 2000; 22: 364-69.
Chua CL, Thomas A. Cystosarcoma phyllodes: a review of surgical options. Surgery. 1989; 105: 141-7.
Zissis C, Apostólikas N, Konstantinidou A. The extent of surgery and prognosis of patients with phyllodes tumor of the breast. Breast Cancer Res Treat. 1998; 48: 205-10.
Hopkins M, McGowan T, Rawlings G, Liu F, Fyles A, Yeho J et al. Phyllode tumor of the breast: a report of 14 cases. J Surg Oncol. 1994; 56: 108-12.
Modena S, Prati G, Mainente M, Massocco A, Montresor E, Pelosi G et.al. Phyllodes tumor of the breast: problems of differential diagnosis and therapeutic approach from an análisis of 17 cases. EJSO. 1993; 19: 70-3.
Page J, Williams J. The radiological features of phyllodes tumour of the breast with clinico-pathological correlation. Clin Radiol. 1991; 44: 8-12.
Buchberger W, Strasser K, Heim K, Muller E, Schrocksnadel H. Phyllodes tumor: findings on mammography, sonography and aspiration cytology in 10 cases. Am J Roent. 1991; 157: 715-19.
Cole–Beuglet C, Soriano R, Kurtz AB. Ultrasound, X-ray mammography and histopathology of cystosarcoma phyllodes. Radiology. 1983; 146: 121-4.
Villafañe N, Villaseñor Y. Imaging evaluation of phylodes tumor at the National Institute of Cancer logy: 86 patient series. BMC Cancer. 2007; 7: A4-A8.
Bhattarai S, Kapila K, Verma K. Phyllodes tumor of the breast. A cytohistologic study of 80 cases. Acta Cytologica. 2000; 44: 790-6.
Krishnamurthy S, Ashafaq R, Shin H, Sneige N. Distinction of phyllodes tumor from fibroadenoma: a reappraisal of an old problem. Cancer. 2000; 90: 342-9.
Shimizu K, Masawa N, Yamada T, Okamoto K, Kanda K. Cytologic evaluation of phyllodes tumor as compared to fibroadenomas of the breast. Acta Cytol. 1994; 38: 891-7.
Vladescu T, Klijanienko J, Caillaud J, Lagacé R, Vielh P. Fine-needle sampling in malignant phyllodes tumors: clinicopathologic study of 22 cases seen at the Institut Curie. Diagn Cytopathol. 2004; 31: 71-6.
Dillon M, Quinn C, Mc Dermott E, O’Doherty A, O’ Higings N, Hill A. Needle core biopsy in the diagnosis of phyllodes neoplasm. Surgery. 2006; 5: 779-84.
Confavreux C, Lurkin A, Mitton N, Blondet R, Saba C, Ranchère D. Sarcomas and malignant phyllodes tumours of the breast. A retrospective study. EJC. 2006; 42: 2715-21.
Chaney A, Pollack A, McNeese M, Zagars G, Pisters P, Pollock R et al. Primary treatment of cystosarcoma phyllodes of the breast. Cancer. 2000; 89: 1502-10.
Stockade A, Leader M. Phyllodes tumor of the breast: response to radiotherapy. Clin Radiol. 1987; 38: 287.
Rao B, Meyer J, Fry C. Most cystosarcoma phyllodes and fibroadenomas have progesterona receptors but lack estrogen receptor: stromal localization of the progesterona receptor. Cancer. 1981; 47: 2016-21.
Kleer C, Giordano T, Braun, Oberman H. Pathologic, immunohistochemical and molecular features of bening and malignant phyllodes tumors of the breast. Mod Pathol. 2001; 14: 185-90.
Lester J, Layfield J, Neuwirth H, Bohman R, Trumbull W. Relation between DNA ploidy and the clinical behavior of phyllodes tumors. Cancer. 1989; 64: 1486-9.
Kuijper A, van der Groep P, van der Wall E, van DiesTP. Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast. Breast Cancer Res. 2005; 7: 808-18.
Feakins R, Mulcahy H, Nickols C, Wells C. P53 expression in phyllodes tumours is associated with histological features of malignancy but does not predict outcome. Histopathology. 1999; 35: 162-9.
Lu Y, Birdsall S, Osin P, Gusterson B, Shipley J. Phyllodes tumours of the breast analyzed by comparative genomic hybridization and association of increased 1q copy number with stromal overgrowth and recurrent. Genes Chromosomes Cancer. 1997; 20: 275-81.
Ladesich J, Damjanov I, Persons D, Jeweell W, Arthur T, Rogana J. Complex kayotype in a low grade phyllodes tumor of the breast. Cancer Gent Cytogent. 2002; 132: 149-51.
Cohn CG, Rutqvist L, Rosendahl I, Silversward C. Prognostic factors in Cystosarcoma Phyllodes. A clinicopathologic Study of 77 Patients. Cancer. 1991; 68: 2017-22.
Staren E, Lynch G, Boyle C, Witt T, Bines S. Malignant cystosarcoma phyllodes. Am Surg. 1994; 60: 583-5.
Hopkins M, McGowan T, Rawlings G, Liu F, Fyles A, Yeoh J et al. Phyllodes tumor of the breast: a report of 14 cases. J Surg Oncol. 1994; 56: 108-12.
de Ross W, Kaye P, Dent D. Factors leading to local recurrente or death alter surgical resection of phyllodes tumours of the breast. Br J Surg. 1999; 86: 396-9.
Hawkins R, Sckofield J, Wiltskaw E, Fisher C, Mckinna J. Ifosfamide is an active drug for chemotherapy of metastatic cystosarcoma phyllodes. Cancer. 1992: 69: 2271-5.