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2012, Número 1

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Rev Esp Cienc Salud 2012; 15 (1)


El receptor para el factor de crecimiento epidérmico (EGFR) y su relación con el cáncer

Zerecero CO, Valle MA, Weiss SB, Soto CI

Idioma: Español
Referencias bibliográficas: 92
Paginas: 15-25
Archivo PDF: 196.80 Kb.


RESUMEN

El receptor para el factor de crecimiento epidérmico (EGFR) y los otros miembros de la familia ErbB son receptores con actividad de cinasa de tirosina que juegan papeles esenciales tanto en condiciones fisiológicas normales como en condiciones cancerosas. Al unirse a sus ligandos, se llevan a cabo cambios conformacionales tanto en los dominios extracelulares como intracelulares de las cinasas de tirosina, dando como resultado la transfosforilación de residuos de tirosina en el dominio Cterminal regulador. Estas tirosinas se convierten en sitios de unión para moléculas señalizadoras y pueden inducir una evasión de la apoptosis, proliferación, hasta invasión y metástasis, procesos que son muy importantes para el fenotipo del cáncer. Se han encontrado varias mutaciones en el gen EGFR, particularmente en el dominio de cinasa en diferentes tipos de cáncer. El significado biológico de esas mutaciones y su relación con otros genes activados en el cáncer se discuten en este trabajo.


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