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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2008, Número 1

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Rev Invest Clin 2008; 60 (1)


El alfa-tocoferol y el ácido alfa-lipoico. Una sinergia antioxidante con potencial en medicina preventiva

González-Pérez Ó, Moy-López NA, Guzmán-Muñiz J

Idioma: Español
Referencias bibliográficas: 88
Paginas: 58-67
Archivo PDF: 164.19 Kb.


RESUMEN

Las especies reactivas de oxígeno (ERO) participan en la inducción y la progresión del daño en muchas patologías humanas, tales como: Infarto cardiaco, isquemia cerebral, neuropatía diabética y enfermedad de Alzheimer, entre otras. En diversos estudios, se ha descrito el sinergismo entre el ácido alfa-lipoico (AAL) y la vitamina E (VE) y potentes efectos antioxidantes pueden ser obtenidos cuando ambos antioxidantes se utilizan simultáneamente. La presente revisión resalta los hallazgos recientes que muestran que la combinación de AAL y VE reduce de manera eficaz el daño oxidativo en isquemia cardiaca y cerebral, así como en otros procesos patológicos relacionados con el incremento de las ERO. Ambos antioxidantes están presentes en una amplia variedad de alimentos y también se encuentran disponibles también en diversos suplementos alimenticios y sus efectos colaterales son escasos. Por lo tanto, el AAL y la VE podrían desempeñar un papel importante en medicina clínica preventiva y nutrición humana.


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