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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2008, Número 1

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Rev Invest Clin 2008; 60 (1)


BMP4: Importante regulador del desarrollo embrionario y la hematopoyesis

Fernández-Sánchez V, Mayani H

Idioma: Español
Referencias bibliográficas: 39
Paginas: 68-74
Archivo PDF: 66.30 Kb.


RESUMEN

Las proteínas morfogénicas del hueso (BMPs) son factores de crecimiento multifuncionales, que pertenecen a la superfamilia del factor de crecimiento transformante-β (TGF-β). El papel de las BMPs en el desarrollo embrionario, así como sus funciones celulares en la etapa postnatal, han sido extensamente estudiadas en años recientes. Una de dichas proteínas es BMP4, la cual ha sido identificada como un regulador pleiotrópico, fundamental para la formación del mesodermo y para la especificación vascular/hematopoyética durante el desarrollo. El estudio de las moléculas que regulan la proliferación, expansión y diferenciación de las células troncales hematopoyéticas (CTH) y células progenitoras hematopoyéticas (CPH) se han enfocado al estudio de algunas citocinas hematopoyéticas, sin embargo, estudios recientes han sugerido que BMP4, al igual que otras moléculas que actúan como morfógenos en la etapa embrionaria, juegan un papel importante en la especificaciones de la hematopoyesis del adulto. En este trabajo se pretende destacar la importancia de BMP4 durante el desarrollo embrionario y su papel en la expansión de CTH y CPH, particularmente aquellas provenientes de la sangre de cordón umbilical (SCU).


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