Gallardo PJC, Espinosa CM, Meléndez ZJ, Maldonado LV

Idioma: Español
Referencias bibliográficas: 23
Paginas: 101-107
Archivo PDF: 136.17 Kb.

RESUMEN

El cultivo de los esferoides tumorales multicelulares (MTS) ha cobrado relevancia en los últimos años como modelo in vitro de los tumores sólidos. La estructura general de los MTS mimetiza las etapas iniciales de los microtumores sólidos in vivo antes de la vascularización. Por lo anterior han sido utilizados en el estudio de la biología tumoral incluyendo migración, invasión y angiogénesis. La resistencia a diferentes fármacos antineoplásicos de los MTS es similar a la del tumor sólido. Además, empiezan a ser incluidos en pruebas fármaco-toxicológicas y en la evaluación de nuevas estrategias terapéuticas contra el cáncer como paso previo a su aplicación en los tumores sólidos in vivo.

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