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2011, Número 3

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Rev Hematol Mex 2011; 12 (3)


Estado de los micronutrientes y parámetros hematológicos y bioquímicos en dubtypes falciformes: reporte preliminar de la India

Pandey S, Ranjan R, Toteja GS, Rao S, Mishra RM, Pandey Sw, Saxena R

Idioma: Español
Referencias bibliográficas: 45
Paginas: 131-137
Archivo PDF: 95.05 Kb.


RESUMEN

Objetivo: evaluar las concentraciones de varios micronutrientes en pacientes con anemia drepanocítica y estudiar los parámetros bioquímicos y hematológicos asociados con la gravedad de la enfermedad.
Material y método: estudioÖ.. al que se incluyeron 25 pacientes con drepanocitosis y 30 sujetos controles. El diagnóstico de drepanocitosis se hizo por cromatografía líquida de alta resolución. En todos los pacientes y controles se analizaron las características clínicas y los parámetros hematológicos. Se midieron la cifras de glucosa, bilirrubina total, proteínas totales, transaminasas, fosfatasa alcalina, proteína C reactiva y los micronutrientes: cinc, selenio, cobre, vitamina A y vitamina E. Los pacientes con drepanocitosis se sublasificaron en tres grupos: heterocigotos (n = 6), homocigotos (n = 8) y dobles heterocigotos para hemoglobinopatía S y talasemia beta (n =11). Las transaminasas hepáticas se encontraron elevadas, principalmente la AST. En los pacientes homocigotos la proteína C-reactiva, fosfatasa alcalina y glucosa se encontraron elevadas, y las concentraciones de cinc, selenio y vitamina A estuvieron significativamente disminuidas. Las concentraciones de vitamina E disminuyeron en los pacientes dobles heterocigotos.
Conclusiones: las concentraciones de varios micronutrientes están disminuidas en los pacientes drepanocíticos de la India y asociadas significativamente con parámetros hematológicos y bioquímicos relacionados con la gravedad del padecimiento


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