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2012, Número 1

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Gac Med Mex 2012; 148 (1)


Trampas extracelulares de neutrófilos (NET), consecuencia de un suicidio celular

Yam-Puc JC, García-Marín L, Sánchez-Torres LE

Idioma: Español
Referencias bibliográficas: 62
Paginas: 68-75
Archivo PDF: 523.66 Kb.


RESUMEN

Recientemente se descubrió que los neutrófilos pueden generar fibras o redes extracelulares llamadas neutrophil extracellular traps (NET), las cuales están compuestas de un esqueleto de ADN sobre el que se encuentran diversos componentes citoplásmicos –entre ellos diversas enzimas– y nucleares. Las NET son una barrera física que en muchos casos evita la diseminación de los microorganismos e incluso facilita su muerte al favorecer una alta concentración local de moléculas antimicrobianas. Por otro lado, su estructura fibrosa limita el daño al tejido donde se generan, al restringir el radio de acción de las moléculas que son liberadas por el neutrófilo. En este trabajo se describe de manera general esta nueva forma de muerte celular de los neutrófilos y las implicaciones que puede tener en diferentes enfermedades.


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