2011, Número 4
<< Anterior Siguiente >>
Med Int Mex 2011; 27 (4)
Hipernatremia intrahospitalaria: ¿indicador de calidad en la atención médica?
Blas SV, Blas MJ
Idioma: Español
Referencias bibliográficas: 44
Paginas: 349-355
Archivo PDF: 250.42 Kb.
RESUMEN
La hipernatremia es el aumento en la concentración de sodio plasmático que excede las 145 mmol/L. Se origina, sobre todo, por la pérdida de agua o por el aporte excesivo de sodio. Los signos y síntomas neurológicos son más comunes en el adulto. Al inicio, la hipernatremia causa descenso en el contenido de agua cerebral, lo que condiciona la contracción del encéfalo, seguida de una etapa adaptativa entre 1 y 3 días. La corrección debe ser cautelosa. La rápida disminución en la concentración de sodio plasmático causa un movimiento brusco de agua hacia el cerebro, lo que puede conducir a convulsiones, daño neurológico permanente o muerte. La hipernatremia es común en el paciente hospitalizado como consecuencia iatrogénica, que se considera un factor de riesgo para mortalidad hospitalaria.
REFERENCIAS (EN ESTE ARTÍCULO)
Singer GG, Brenner MB. Alteraciones de líquidos y electrolitos. En: Harrison. Principios de Medicina Interna. 16ª ed. México: McGraw-Hill Interamericana, 2005;303-310.
Marino LP. The ICU Book. 2ª ed. Baltimore: William Wilkins, 1998;631-640.
Rose BD. Post TW. Situaciones de hiperosmolaridad-hipernatremia. En: Trastornos de los electrolitos y del equilibrio ácido. 5ª ed. Madrid: Marbán, 2002;747-793.
Ayus JC, Caramelo C. Trastornos del equilibrio del agua. En: Shoemaker. Tratado de Medicina Crítica y Terapia Intensiva. 4ª ed. Buenos Aires: Panamericana, 2002;834-838.
Sterns RH, Narins RG. Hypernatremia and hiponatremia. En Adrogue. Acid-Base and electrolyte disorders. New York: Churchill Livingstone, 1991;161-174.
Palevsky PM, Bhagrath R, Greenberg A. Hypernatremia in hospitalized patients. Ann Intern Med 1996;124:197-203.
Mahowald JM, Himmelstein DU. Hypernatremia in the elderly: relation to infection and mortality. J An Geriatr Soc 1981;29:177-180.
Himmelstein DU, Jones AA, Woolhandler S. Hypernatremic dehydration in nursing home patients: an indicator of neglect. J An Geriatr Soc 1993;31: 466-471.
Lianis G, Nasilist, Donnas M, Spyron A, et al. Clinical and laboratory characteristics of hypernatremia in an internal medicine clinic. Nephrol Dial Trasplant 2008;23:136-143.
Paleusky PM. Hypernatremia. Semin Nephrol 1998;18:20-30.
Borra SI, Beredo R, Kleinfeld M. Hypernatremia in the aging; causes, manifestations and outcome. J Natl Med Assoc 1995;87:220-224.
Snyder NA. Feigal DW, Areff AI. Hypernatremia in elderly patients: a heterogeneous, morbid, and iatrogenic entity. Ann Intern Med 1987;107:309-319.
Polderman KN, Schreuder WO, Strack van Schijndel RJM, et al. Hypernatremia in the intensive care unit: An indicator of quality of care? Crit Care Med 1999;27:1105-1108.
Devita MU, Gardenswartz MH, Konechy A, Zabetakis PM. Incidence and etiology of hipernatremia in an intensive care unit. Clin Nephrol 1990;34:163-166.
Mandal AK, Saklayen MG, Hillman NM, Market RJ. Predictive factors for high mortality in hypernatremia patients. An J Emerg Med 1997;15:130-132.
Alyagari U, Derbert E, Diringer HN. Hypernatremia in the neurologic intensive care unit: how high is too high? J Critic Care 2006;21:163-172.
Lianis G, Kalogiron M, Sangus V, Elisa FM. Therapeutic approach in patients with dysnatremias. Nephrol Dial Transplant 2006;21:1564-1569.
Adrogue HJ, Madias NF. Hypernatremia. N Engl J Med 2000;342:1493-1499.
Mac Manus ML, Churchwell KB, Strange K. Regulation of cell volume in health and disease. N Engl J Med 1995;333:1260-1266.
Kang SK, Kim W, Nan S. Pathogenesis and treatment of hypernatremia. Nephrol 2002;92:14-17.
Bagshaw SM, Towsend DR, McDermid RC. Disorders of sodium and water balance in hospitalized patients. Can J Anaesth 2009;56:151-167.
Chasagne P, Druesne L, Capet C, Menard JF, Borcoff E. Clinical presentation of hypernatremia in the elderly patients: a case control study. J An Geriatr Soc 2006;54:1225-1230.
Milionis HJ, Lianis G, Elisaf MS. Plasma sodium changes in the hyperglycemic state: clinical aspects of pathophysiology and management. Int J Diabete Met 2001;9:60-66.
Mc Gee S, Abernethy W, Simel DL. Is this patient hypovolemic. JAMA 1999;28:1022-1209.
Katz MA. Hyperglycemia induced hyponatremia calculation of expected serum sodium depression. N Engl J Med 1973;289:843-844.
Lianis G, Giamoutsos C, Elisaf MS. Hyperosmolar Nonketotic syndrome with hypernatremia: how can we monitor treatment? Diabetes-Metabolism 2000;26:403-405.
Gennari FJ. Serum Osmolality: uses and limitations. N Engl J Med 1984;310:102-105.
Nguyen MK, Kurtz I. A new quantitative approach to the treatment of the dysnatremias. Clin Exp Nephrol 2003;7:125-137.
Nguyen MK, Kurtz I. Analysis of current formulas used for treatment of the dysnatremias. Clin Exp Nephrol 2004;8:12-16.
Adrogue HJ, Madias NE. Aiding fluid prescription for the dysnatremias. Intensive Care Med 1997;23:309-316.
Brown WD. Osmotic demyelination disorders: central pontine and extrapontine myelinolysis. Curr Opin Neurol 2000;13:691-697.
Moder KG, Hurley DL. Fatal hypernatremia from exogenous salt intake: report of a case and review of the literature Mayo Clin Proc 1990;65:1587-1594.
Hilton A, Pellegrino Va, Scheinsketcl CD. Avoiding common problems associated with intravenous fluid therapy. MJA 2008;189(9):509-513.
Stoner DF. Hyperosmolar hyperglycemic state. An Fam Phsician 2005;71:1723-1730.
Moghissi ES, KorytKowsky MT, DiNardo M, et al. American Association of clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 2009; 32:1119-1131.
Ferg PU. Hypernatremia and hypertonic syndromes. Med Clin North An 1981;65:271-290.
Worthley LI. Hyperosmolar coma treated with intravenous sterile water. A study of three cases. Arch Intern Med 1986;146:945-947.
Tanaka S, Kabayashi T, Kamanami D, et al. Paradoxical glucose infusion for hypernatremia in diabetic hyperglycemic hyperosmolar syndrome. J intern Med 2000;248:166-168.
Brown WD. Osmotic demyelination disorders: central pontine and extrapontine myelinolysis. Curr Opin Neurol 2000;13:691-697.
Franke DA, Scheinkestel DC, Hilton KA, Pellegrino AN. Avoiding common problems associated with intravenous fluid therapy. Med J Aust 2009;190:718-725.
Minhtri K, Nguyen MJ, Kurtz I. Analysis of current formulas used for treatment of the dysnatremias. Clin Exp Nephrol 2004;8:12-16.
Smiley D, Rhee M, Pengl R, Mulligan P, et al. Safety and efficacy of continuous insulin infusion in noncritical care settings. J Hosp Med 2010;5:212-217.
Taylor BE, Schallom ME, Sona CS, Buchman TG, et al. Efficacy and safety of an insulin infusion protocol in a surgical ICU. J Am Coll Surg 2006;200:1-9.
Joehberger S, Mayr Nd, Luckner G, et al. Serum Vasopressin concentrations in critically ill patients. Crit Care Med 2006;34:293-299.