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2006, Número 2

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Enf Infec Microbiol 2006; 26 (2)


Actividades antibacterianas de lactoferrina

Drago SME

Idioma: Español
Referencias bibliográficas: 44
Paginas: 58-63
Archivo PDF: 134.84 Kb.


RESUMEN

Diversas especies de mamíferos producen lactoferrina, una glicoproteína no hémica de unión a hierro perteneciente a la familia de las transferrinas. La lactoferrina está presente en una variedad de fluidos exocrinos y es particularmente abundante en leche y calostro. La lactoferrina es un componente esencial de los mecanismos innatos de defensa del hospedero, puesto que exhibe diversas actividades antibacterianas y además por su estratégica presencia en las secreciones diseminadas sobre las superficies mucosas que continuamente están expuestas al contacto con bacterias patógenas. La investigación básica de las propiedades antibacterianas de la lactoferrina ha influido en estudios clínicos relacionados con estrategias profilácticas para la prevención de enfermedades bacterianas, así como en el diseño de métodos terapéuticos para el tratamiento de infecciones causadas por bacterias resistentes a antibióticos.


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