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Instituto Nacional de Neurología y Neurocirugía

2008, Número 1

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Arch Neurocien 2008; 13 (1)


La actividad de Na+, K+ ATPasa en cerebro puede ser un marcador de estrés oxidativo

Calderón GD, Hernández GE, Barragán MG

Idioma: Español
Referencias bibliográficas: 42
Paginas: 31-34
Archivo PDF: 78.00 Kb.


RESUMEN

La enzima Na+, K+ ATPasa en cerebro es una proteína integral de la membrana celular encargada de transportar iones de sodio y potasio, es propensa a sufrir alteraciones en presencia de otros iones y moléculas de carácter endógeno y exógeno, incluyendo a los radicales libres provenientes del metabolismo de oxígeno y nitrógeno celular. Los radicales libres provocan estrés oxidativo, daño al ADN e incluso muerte celular, es posible dar seguimiento al daño de estos radicales mediante la evaluación de la enzima Na+, K+ ATPasa como importante biomarcador de estrés oxidativo en cerebro, como se muestra en el presente trabajo de revisión.


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