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Instituto Nacional de Salud Pública

2009, Número 2

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salud publica mex 2009; 51 (2)


Asociación de los polimorfismos AgNORs con lesiones intraepiteliales escamosas, carcinoma cervical e infección por VPH

Alarcón-Romero LC, Illades-Aguiar B, Flores-Alfaro E, Terán-Porcayo MA, Antonio-Véjar V, Reyes-Maldonado E

Idioma: Ingles.
Referencias bibliográficas: 40
Paginas: 134-140
Archivo PDF: 142.37 Kb.


RESUMEN

Objetivo. Evaluar la relación entre los polimorfismos de AgNORs con las lesiones intraepiteliales escamosas (LIE) y carcinoma de células escamosas (CCE). Material y métodos. Se estudiaron sesenta mujeres del estado de Guerrero, México. La detección del VPH fue por PCR y los AgNORs por impregnación argéntica; se contaron 100 células y se clasificaron por tipo de polimorfismo de AgNORs: típico (esférico) y atípicos (largo, forma de riñón o de racimo). Resultados. El 100% de los casos presentaron infección por VPH, se encontraron nueve genotipos diferentes de VPH de alto riesgo, el 16 fue el más común (48.6%). La forma esférica de los polimorfismos de AgNORs mostró una disminución con el desarrollo neoplásico y las atípicas incrementaron progresivamente con SIL y SCC (p-tendencia‹0.001). Conclusiones. Los polimorfismos AgNORs se incrementan progresivamente con el grado de lesión histológica, y pueden ser útiles en el pronóstico de progresión del carcinoma cervical.


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