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2009, Número 1

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Rev Mex Ing Biomed 2009; 30 (1)


Estudio de la hidratación de cementos de fosfato tricálcico

Medina N, Rodríguez H, Piña C

Idioma: Español
Referencias bibliográficas: 33
Paginas: 54-65
Archivo PDF: 386.75 Kb.


RESUMEN

Se estudiaron la cinética de reacción, la microestructura y los mecanismos de transformación de los reactivos de tres biocementos elaborados con a-tricalcio fosfato (a-TCP), semillas de hidroxiapatita (HA) y óxido de zirconio (ZrO2). Se encontró que el uso de aditivos ricos en Ca o P, cuya solubilidad es mayor que la del reactivo base, favorece la sobresaturación de la fase líquida para precipitar en CDHA o HA. El CaCl2 y el NaH2PO4 actúan como importantes fuentes de Ca2+y PO43-. Se demostró que las concentraciones utilizadas convierten comple tamente al a-TCP en HA en sólo horas, además que la cristalinidad es mayor empleando sales de NaH2PO4 que con Na2HPO4. Tienen la ventaja sobre los cementos de metil metacrilato que son usados generalmente, de reaccionar por debajo de los 40 °C mientras los de MMA alcanzan cerca de los 100 °C dañando el tejido circundante. Además, estos biocementos son bioactivos y bioabsorbibles. Se proponen para la reparación ósea y la fijación de implantes y/o prótesis.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clinical Orthopaedics and Related Research 1981; 157: 259-278.

  2. Higgins TF, Dodds SD, Wolfe SW. A Biomechanical analysis of fixation of intra-articular distal radial fractures with calcium phosphate bone cement. J Bone and Joint Surg 2002; 84: 1579-1586.

  3. Bigi A, Panzavolta S, Rubini K. Setting mechanism of a biomimetic bone cement. Chem Mater 2004; 16(19): 3740-3745.

  4. Ginebra MP, Driessens FCM, Planell JA. Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis. Biomaterials 2004; 25: 3453-3462.

  5. Ginebra MP, Fernández E, De Maeyer EAP, Verbeeck RMH, Boltong MG, Ginebra J, Driessens FCM, Planell JA. Setting reaction and hardening of an apatitic calcium phosphate cements. J Dent Res 1997; 76(4): 905-912.

  6. Fernández E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA. Production and characterization of new calcium

  7. phosphate bone cements in the CaHPO4—a-Ca3(PO4)2 system: pH, workability and setting times. J Mater Sci Mater Med 1999; 10: 223-230.

  8. Ginebra MP, Driessens FCN, Planell JA. Effect of the size on the micro and nanostructural features of calcium phosphate cement: a kinetic analysis. Biomaterials 2004; 25: 3453-3462.

  9. Boltong MG, Fernández E. Common ion effect on some calcium phosphate cements. Clinical Materials 1994; 16: 99-103.

  10. Brown PW, Fulmer MT. The effects of electrolytes on the rates of hydroxyapatite formation at 25 and 38 °C. J Biomed Mater Res 1996; 31: 395-400.

  11. Ishikawa K, Ishikawa Y, Tagaki S, Chow LC. Properties and mechanism of fast-setting calcium phosphate cements. J Mater Sci Mater Med 1995; 6: 528-533.

  12. Li J, Liao H, Sjöström. Characterization of calcium phosphates precipitated from simulated body fluid of different buffering capacities. Biomaterials1997; 18: 743-747.

  13. Arai Y. Chemistry of powder production. Chapman & Hall, Great Britain, 1996.

  14. Ginebra MP. Desarrollo y caracterización de un cemento óseo basado en fosfato tricálcico-a para aplicaciones quirúrgicas. Tesis doctoral, Universitat Politecnica de Catalunya, Cataluña, España, 1996.

  15. Fernández E, Gil FJ, Best SM, Ginebra MP, Driessens FCM, Planell JA. Improvement of the mechanical properties of new calcium phosphate bone cements in the CaHPO4—a-Ca3(PO4)2 system: Compressive strength and microstructural development. J Biomed Mater Res 1998; 41: 560-567.

  16. Ginebra MP, Fernández E, Maeyer E et al. Setting reaction and hardening of an apatitic calcium phosphate cement. J Dent Res 1997; 76 (4): 905-912.

  17. Cullity BD. Elements of X-Ray diffraction. Addison-Wesley, USA, 1978.

  18. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clinical Orthopaedics and Related Research 1981; 157: 259-278.

  19. Higgins TF, Dodds SD, Wolfe SW. A Biomechanical analysis of fixation of intra-articular distal radial fractures with calcium phosphate bone cement. J Bone and Joint Surg 2002; 84: 1579-1586.

  20. Bigi A, Panzavolta S, Rubini K. Setting mechanism of a biomimetic bone cement. Chem Mater 2004; 16(19): 3740-3745.

  21. Ginebra MP, Driessens FCM, Planell JA. Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis. Biomaterials 2004; 25: 3453-3462.

  22. Ginebra MP, Fernández E, De Maeyer EAP, Verbeeck RMH, Boltong MG, Ginebra J, Driessens FCM, Planell JA. Setting reaction and hardening of an apatitic calcium phosphate cements. J Dent Res 1997; 76(4): 905-912.

  23. Fernández E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA. Production and characterization of new calcium phosphate bone cements in the CaHPO4—a-Ca3(PO4)2 system: pH, workability and setting times. J Mater Sci Mater Med 1999; 10: 223-230.

  24. Ginebra MP, Driessens FCN, Planell JA. Effect of the size on the micro and nanostructural features of calcium phosphate cement: a kinetic analysis. Biomaterials 2004; 25: 3453-3462.

  25. Boltong MG, Fernández E. Common ion effect on some calcium phosphate cements. Clinical Materials 1994; 16: 99-103.

  26. Brown PW, Fulmer MT. The effects of electrolytes on the rates of hydroxyapatite formation at 25 and 38 °C. J Biomed Mater Res 1996; 31: 395-400.

  27. Ishikawa K, Ishikawa Y, Tagaki S, Chow LC. Properties and mechanism of fast-setting calcium phosphate cements. J Mater Sci Mater Med 1995; 6: 528-533.

  28. Li J, Liao H, Sjöström. Characterization of calcium phosphates precipitated from simulated body fluid of different buffering capacities. Biomaterials1997; 18: 743-747.

  29. Arai Y. Chemistry of powder production. Chapman & Hall, Great Britain, 1996.

  30. Ginebra MP. Desarrollo y caracterización de un cemento óseo basado en fosfato tricálcico-a para aplicaciones quirúrgicas. Tesis doctoral, Universitat Politecnica de Catalunya, Cataluña, España, 1996.

  31. Fernández E, Gil FJ, Best SM, Ginebra MP, Driessens FCM, Planell JA. Improvement of the mechanical properties of new calcium phosphate bone cements in the CaHPO4—a-Ca3(PO4)2 system: Compressive strength and microstructural development. J Biomed Mater Res 1998; 41: 560-567.

  32. Ginebra MP, Fernández E, Maeyer E et al. Setting reaction and hardening of an apatitic calcium phosphate cement. J Dent Res 1997; 76 (4): 905-912.

  33. Cullity BD. Elements of X-Ray diffraction. Addison-Wesley, USA, 1978.




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