2008, Número 1
Linfoma de células grandes con inmunofenotipo B intravascular en una paciente con mastitis recurrente, demencia y lesiones en piel.
Reporte de un caso y revisión de la literatura
Ylgovsky-Weintraub L, Videgaray-Ortega F, De la Barreda-Becerril F, Molinar-Horcasitas L
Idioma: Español
Referencias bibliográficas: 50
Paginas: 25-30
Archivo PDF: 176.31 Kb.
RESUMEN
Reportamos el segundo caso de linfoma de células grandes con inmunofenotipo B intravascular asociado a mastitis bilateral recurrente en una paciente de 87 años de edad. Este tipo de linfoma se caracteriza por la afección del sistema nervioso central y piel. En el sistema nervioso central se manifiesta con confusión, demencia y déficit neurológico múltiple, mientras que en la piel con la presencia de nódulos, zonas eritematosas y telangiectasias. El diagnóstico es histopatológico y el tratamiento es a base de quimioterapia y corticoesteroides. El pronóstico depende del diagnóstico oportuno y tratamiento temprano.
REFERENCIAS (EN ESTE ARTÍCULO)
Jaffe E, Harris N, Stin H, Vardiman J. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization of Tumours. Lyon, France: Press; 2001: 177-178.
Ferreri AJ, Campo E, Seymour JF et al. Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’. Br J Haematol 2004; 127: 173-183.
Kanda M, Suzumiya J, Ohshima K et al. Intravascular large cell lymphoma: clinicopathological, immunohistochemical and molecular genetic studies. Leuk Lymphoma 1999; 34: 569-580.
Khalidi HS, Brynes RK, Browne P et al. Intravascular large B-cell lymphoma: the CD5 antigen is expressed by a subset of cases. Mod Pathol 1998; 11: 983-988.
Ferry JA, Harris NL, Picker LJ et al. Intravascular lymphomatosis (malignant angioendotheliomatosis). A B-cell neoplasm expressing surface homing receptors. Mod Pathol 1988; 1: 444.
Baehring JM, Longtine J, Hochberg FH. A new approach to the diagnosis and treatment of intravascular lymphoma. J Neurooncol 2003; 61: 237-248.
Demirer T, Dail DH, Aboulafia DM. Four varied cases of intravascular lymphomatosis and a literature review. Cancer 1994; 73: 1738-1745.
DiGiuseppe JA, Nelson WG, Seifter EJ et al. Intravascular lymphomatosis: a clinicopathologic study of 10 cases and assessment of response to chemotherapy. J Clin Oncol 1994; 12: 2573-2579.
Stroup RM, Sheibani K, Moncada A et al. Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations. Cancer 1990; 66: 1781-1788.
Domizio P, Hall A, Cotter F et al. Angiotropic large cell lymphoma (ACLC): morphological, immunohistochemical and genotypic studies with analysis of previous reports. Hematol Oncol 1989; 7: 195-206.
Calamia KT, Miller A, Shuster EA et al. Intravascular lymphomatosis. A report of ten patients with central nervous system involvement and a review of the disease process. Adv Exp Med Biol 1999; 455: 249-265.
Walls JG, Hong YG, Cox JE et al. Pulmonary intravascular lymphomatosis: presentation with dyspnea and air trapping. Chest 1999; 115: 1207-1210.
Fukushima A, Okada Y, Tanikawa T et al. Primary bilateral adrenal intravascular large B-cell lymphoma associated with adrenal failure. Intern Med 2003; 42: 609-614.
Aouba A, Diop S, Saadoun D et al. Severe pulmonary arterial hypertension as initial manifestation of intravascular lymphoma: case report. Am J Hematol 2005; 79: 46-49.
Cossu A, Deiana A, Lissia A et al. Nephrotic syndrome and angiotropic lymphoma report of a case. Tumori 2004; 90: 510-513.
Bauer A, Perras B, Sufke S et al. Myocardial infarction as an uncommon clinical manifestation of intravascular large cell lymphoma. Acta Cardiol 2005; 60: 551-555.
Von Kempis J, Kohler G, Herbst EW et al. Intravascular lymphoma presenting as symmetric polyarthritis. Arthritis Rheum 1998; 41: 1126-1130.
Roglin J, Boer A. Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin. Br J Dermatol 2007 May 15 (Epub ahead of print).
Weichert G, Martinka M, Rivers JK. Intravascular lymphoma presenting as telangiectasias: response to rituximab and combination chemotherapy. J Cutan Med Surg 2003; 7(6): 460-463.
Armitage J, Weisenburger D. New approach to classifying Non-Hodgkin’s lymphomas: Clinical features of the major histologic subtypes. J Clin Oncol 1998; 16: 2780.
De Paepe P, Achten R, Verhoef G et al. Large cleaved and immunoblastic lymphoma may represent two distinct clinicopathologic entities within the group of diffuse large B-cell lymphomas. J Clin Oncol 2005; 23: 7060.
Alizadeh AA, Eisen MB, Davis RE et al. Distinct types of diffuse large B-cell limphoma identified by gene expression profiling. Nature 2000; 23: 7060.
Monti S, Savage KJ, Kutok JL et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005; 105: 1851.
McBride JA, Rodríguez J, Luthra R et al. T-cell-rich B large-cell lymphoma simulating lymphocyte-rich Hodgkin’s disease. Am J Surg Pathol 1996; 20: 193.
Ansell SM, Stenson M, Habermann TM et al. CD4+ T-cell immune response to large B-cell non Hodgkin’s lymphoma predicts patient outcome. J Clin Oncol 2001; 19: 720.
Doggett RS, Wood GS, Horning S et al. The immunologic characterizations of 95 nodal and extranodal diffuse large cell lymphomas in 89 patients. Am J Pathol 1984; 115: 245.
Shipp MA, Ross KN, Tamayo P et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 2002; 8: 68.
Moller MB, Pedersen NT, Christensen BE. Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation-a population-based study of 1575 cases. Br J Haematol 2004; 124: 151.
Paryani S, Hoppe R, Burke J et al. Extralymphatic involvement in diffuse non-Hodgkin’s lymphoma. J Clin Oncol 1983; 1: 682
Reddy S, Pellettiere E, Saxena V et al. Extranodal non-Hodgkin’s lymphoma. Cancer 1980; 46: 1925.
Rudders R, Ross M, deLellis R. Primary extranodal lymphoma. Cancer 1978; 42: 406.
Bunn P Jr, Schein P, Banks P et al. Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: Leukemia revisited. Blood 1976; 47: 3.
Grange F, Bekkenk MW, Wechsler J et al. Prognostic factors in primary cutaneous large B-cell lymphomas: a European multicenter study. J Clin Oncol 2001; 19: 3602.
Ribrag V, Bibeau F, El Weshi A, Frayfer J. Primary breast lymphoma: a report of 20 cases. Br J Haematol 2001; 115: 253.
Domchek SM, Hecht JL, Flemig MD et al. Lymphomas of the breast: primary and secondary involvement. Cancer 2005; 94: 6.
Aviles A, Delgado S, Nambo MJ et al. Primary breast lymphoma: result of a controlled clinical trial. Oncology 2005; 69: 256.
A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s lymphoma prognostic factors project. N Engl J Med 1993; 329: 987.
Wilder RB, Rodriguez MA, Medeiroa LJ et al. International prognostic index-based outcomes for diffuse large B-cell lymphomas. Cancer 2002; 94: 3083.
López-Guillermo A, Colomo L, Jiménez M et al. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extra nodal origin. J Clin Oncol 2005; 23: 2797.
Wilson WH, Grossbard ML, Pittaluga S et al. dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood 2002; 99: 2685.
Fisher F, Gaynor ER, Dahlberg S et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma. N Engl J Med 1993; 328: 1002
Lee AY, Connors JM, Kilmo P et al. Late relapse in patients with diffuse large-cell lymphoma treated with MACP-B. J Clin Oncol 1997; 15: 1745.
Moller MB, Pedersen NT, Christensen BE. Conditional survival of patients with diffuse large B-cell lymphoma. Cancer 2006; 106: 2165.
Cobcroft R. Images in haematology. Diagnosis of angiotropic large B-cell lymphoma from a peripheral blood film. Br J Haematol 1999; 104: 42.
Chapin JE, Davis LE, Kornfeld M, Mandler RN. Neurologic manifestations of intravascular lymphomatosis. Acta Neurol Scand 1995; 91: 494.
Kiyohara T, Kumakiri M, Kobayashi H et al. A case of intravascular large B-cell lymphoma mimicking erythema nodosum: the importance of multiple skin biopsies. J Cutan Pathol 2000; 27: 413.
Gill S, Melosky B, Haley L, ChanYan C. Use of random skin biopsy to diagnose intravascular lymphoma presenting as fever of unknown origin. Am J Med 2003; 114: 56.
Bouzani M, Karmiris T, Rontogianni D et al. Disseminated intravascular B-cell lymphoma: clinicopathological features and outcome of three cases treated with anthracycline-based immunochemotherapy. Oncologist 2006; 11: 923.
Monteiro M, Duarte I, Cabecadas J, Orvalho ML. Intravascular large B-cell lymphoma of the breast. Breast 2005; 14(1): 75-8.
Gordan LN, Grow WB, Pusateri A, Douglas V, Mendenhall NP, Lynch JW. Phase II trial of individualized rituximab dosing for patients with CD20-positive lymphoproliferative disorders. Journal of Clinical Oncology 2005; 23: 6-20.