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2021, Number 2

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Med Crit 2021; 35 (2)

Vitamin D status in sepsis in the Adult Intensive Care Unit

López MHA, Razcón EA, Barrientos QL, Sánchez NVM, Chávez PCE

Language: Spanish
References: 29
Page: 65-78
PDF size: 306.29 Kb.


ABSTRACT

Introduction: Nowadays, Vitamin C research in sepsis has been of great importance. However, and especially in the critical care setting, there's limited but significant evidence about the high prevalence of vitamin D deficiency in sepsis and septic shock patients; correlating with the severity and the organ dysfunction risk. Material and methods: Retrospective study, monocentric, observational and descriptive, sample taken by convenience. 492 patients were analyzed, which 105 had sepsis diagnosis, and 30 of these patients had vitamin D quantification. The median age was 56 years, predominantly male (70%), the main medical history were oncologic illness, immunosuppression. At the time of intensive care unit admission 73.3% were in shock state, 70% on mechanical ventilation, with a mean mortality score of 16 points (APACHE II score, 25% mortality risk), and 8 points in the SOFA score (15-20% mortality risk. According with the vitamin D levels, 2 groups were found: Insufficiency (less than 10 ng/mL) and deficiency (more than 10 ng/mL). Results: There was no significant age difference (p = 0.724), length of stay difference (p = 0.755), SOFA (p = 0.241). There is statistically significance on the APACHE II scores, with a mean score of 19.5 points in the less than 10 ng/mL group (mortality risk 25%), and 14.5 points in the greater than 10 ng/mL group (mortality risk 15%). Mortality estimation was 42.9% in the less than 10 ng/mL group, and 12.5% in the greater than 10 ng/mL group, however, this was not statistically significant data. Conclusions: There is no statistically significant correlation between vitamin D levels and hospital length of stay. Mortality was higher in patients with vitamin D levels lesser than 10 ng/mL (42.9%), and 12.5% mortality in those with levels greater than 10 ng/mL. However the study sample is small, it will be necessary to increase the number of patients in order to obtain more statistically significant data.


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