2020, Number 3
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Rev Mex Mastol 2020; 10 (3)
Current affairs in breast cancer systemic treatment
Luna-Palencia RL, De la Cruz-Escobar EN
Language: Spanish
References: 61
Page: 71-82
PDF size: 223.32 Kb.
ABSTRACT
Breast cancer is the leading cause of dead because of cancer in women. Four molecular phenotypes are known, associated with a distinct prognosis and treatment options. In the treatment of breast cancer with positive hormonal receptors, without overexpression of HER2, the major progress have been seen in metastatic setting with the addition of cyclin dependent kinases 4/6 inhibitors to endocrine therapy, with median progression-free survival of 27.6 months with palbociclib/letrozole (PALOMA-2 trial) or overall survival of 58.7 months with the addition of ribociclib to the hormonal therapy in premenopausal women (MONALEESA-7 trial). Anti-HER2 therapies have improved considerably the prognosis of the patients with breast cancer with overexpression of HER2, in early breast cancer with adjuvant trastuzumab or trastuzumab emtansine and in metastatic setting with the addition of pertuzumab to trastuzumab and docetaxel therapy (CLEOPATRA trial) with median overall survival of 56.5 meses with the double block. In triple negative women, the addition of immunotherapy with the PD-L1 inhibitor atezolizumab to the chemotherapy with nab-paclitaxel (IMpassion 130 trial) showed a median overall survival of 25 months in patients with positive expression of PD-L1.
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