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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2006, Number 3

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An Med Asoc Med Hosp ABC 2006; 51 (3)

Acute intermittent porphyria in pregnancy

González CJ, López RE, Herrera ABP, Alfaro AJ, Navarro MC, Chávez SG

Language: Spanish
References: 8
Page: 134-137
PDF size: 84.05 Kb.


ABSTRACT

History: Porphyrias are a heterogeneous group of either inherited or acquired disorders of the enzymatic biosynthesis of porphyrins. In these diseases, specific abnormalities of enzymes cause diverse clinical manifestations including abdominal pain, gastrointestinal alterations and psychiatric manifestations. Case: A 36 year-old female, gravid 3 cesarean 2 with a 7 week pregnancy was admitted with lumbar and diffuse abdominal pain. She was managed with analgesics and discharged after 48 hrs; she was readmitted 24 hrs later with tonic clonic seizures. Laboratory exams showed hyponatremia, hypokalemia and anemia. A diagnosis of acute intermittent porphyria was confirmed with elevated porphyrinis in urine. The patient was released after 2 weeks, ending in spontaneous abortion 5 days later. Conclusion: The diagnosis of acute intermittent porphyria is complex because of the wide spectrum of symptoms. Pregnancy or the puerperium might exacerbate the disease.


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