medigraphic.com
Anales de Otorrinolaringología Mexicana

2021, Number 1

<< Back Next >>

Otorrinolaringología 2021; 66 (1)

Mandibular lesion as the first sign of Langerhans cell histiocytosis

Ramos-Martínez CI

Language: Spanish
References: 11
Page: 80-86
PDF size: 310.54 Kb.


ABSTRACT

Background: Langerhans cell histiocytosis in children has multiple manifestations in the head and neck region. It can affect any organ, skin, bone (lytic lesions), nodes, ears (otorrhea) and central nervous system. It is caused by the proliferation of CD1a positive immature dendritic cells, mutation of oncogene BRAF and proinflammatory cytokines.
Clinical case: A 2-year-old female patient with a mandibular lytic lesion, solitary bone lesion, known as eosinophilic granuloma; the symptoms were toothache, tenderness, erythema and loose teeth.
Conclusions: This is the mildest form of the disease, Langerhans cell histiocytosis accounts for 1% of all bone neoplastic, and the mandible is involved in 7.9% of the cases. Diagnosis is stablished by biopsy with histological and immunochemistry. Patients have good prognosis in 98%, but some may experience long-term permanent consequences.


REFERENCES

  1. DiCaprio M, Roberts T. Diagnosis and management of Langerhans cell histiocytosis abstract. Am Acad Orthop Surg 2014; 22: 643-652. doi. 10.5435/JAAOS-22-10-643.

  2. Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, et al. Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Adv Dermatol Alergol 2018; 1: 6-17. doi. 10.5114/pdia.2017.67095.

  3. Kaiserian M, Altberg G, Greenstein J, Hahn B. Langerhans cell histiocytosis. J Emerg Med 2019; 56; 12. https://doi. org/10.1016/j.jemermed.2018.12.006.

  4. Donadieu J, Héritier S. Histiocytose langerhansienne de l’enfant. Presse Med 2017; 46: 85-95.

  5. Haupt R, Milen M, Astigarraga I, Scha E, et al. Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer 2013; 60: 175-184. doi. 10.1002/pbc.24367.

  6. Kim J, Yi W, Heo M, Lee S, et al. Langerhans cell histiocytosis of the jaw, a mimicker of osteomyelitis on CT and MR images. Medicine (Baltimore) 2019; 98: 27. doi. 10.1097/ MD.0000000000016331.

  7. Xia X, Liu Y, Wang L, Xing Z, et al. Neck masses in children: a 10-year single-centre experiencein Northwest China. Br J Oral Maxillofac Surg 2019; 57: 729-733. https://doi. org/10.1016/j.bjoms.2019.06.009.

  8. Gov-Ari E, Leann B . Correlation between pre-operative diagnosis and post-operative pathology reading in pediatric neck masses—A review of 282 cases. Int J Pediatr Otorhinolaryngol 2015; 79 (1): 2-7. doi. 10.1016/j. ijporl.2014.11.011.

  9. Bajracharya B, Poudel P, Bajracharya D, Bhattacharyya S, et al. Eosinophilic granuloma of mandible: A diagnostic challenge. Kathmandu Univ Med J 2018; 62 (2): 201-3.

  10. Moudi M, Go R, Yien CY, Nazre M. Vinca alkaloids. Int J Prev Med 2013; 4 (11): 1231-5.

  11. Gao Y, Su M, Tang J, Pan C, et al. Treatment outcome of children with multisystem Langerhans cell histiocytosis: The experience of a single children’s hospital in Shanghai, China. J Pediatr Hematol Oncol 2018; 40 (1): 9-12. doi. 10.1097/MPH.0000000000001016.




2020     |     www.medigraphic.com