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2020, Number 2

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Invest Medicoquir 2020; 12 (2)

The heart in sepsis

Quevedo BY, Pérez AG, Abdo CA, Quiles GLM, Hernández FE, Leal AG, Blanco GMÁ, Lopez DD

Language: Spanish
References: 33
Page:
PDF size: 336.58 Kb.


ABSTRACT

Sepsis is one of the leading causes of death in the Intensive Care Unit. Myocardial dysfunction paten the multiple organ dysfunction of secondary to sepsis and septic shock. The majority of patients who develop it do so within the first 48 hours of evolution. It is characterized by being transient and reversible; patients who survive recover their cardiac function between 7 and 10 days. Cardiac dysfunction induced by sepsis is the result of variety of hemodynamic disorders,of metabolic, microvascular, inmulogical, neuroendocrine factors, alterations at the level of the endothelium, circulating myocardial depressant substances, dysfunction in intracelular management, activation of apoptosis, mitichondrial dysfunction and oxidative stress which act synergistically to give rise to the clinical manifestations of this dysfunction ,so far the pathophysiology of myocardial dysfunction induced by sepsis is not well defined by its pathogenic complexity. This paper presents a systematic and updated review of septic cardiomiopathy, about pathopysiology and the molecular and cellular mechanisms that cause it, as well as the importance of the use echocardiography and biomarker for the diagnosis and follow-up of patients with sepsis induced myocardial dysfunction.


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