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2020, Number 1

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Rev Cub Med Int Emerg 2020; 19 (1)

Biomarkers in sepsis and their predictive value

Francisco PJC, Llerena MMM, Piedra GM, Concepción PE

Language: Spanish
References: 29
Page: 1-12
PDF size: 319.97 Kb.


ABSTRACT

Introduction: Sepsis is a disease that causes high mortality and it is recognized worldwide. The incorporation of new biomarkers makes it possible to obtain a rapid and accurate diagnosis.
Objective: To determine the predictive capacity in a group of biomarkers in patients with sepsis.
Methods: A case-control study was conducted with 70 patients admitted to the Intensive Care Unit at Dr. Luis Díaz Central Military Hospital, from January 2015 to January 2017. The sample was divided into 51 patients (group of cases) and 19 (control group). The demographic variables considered were stay and mortality. Most sensitive biomarkers for the initial diagnosis and with the best predictive value were determined. Descriptive statistics were used and diagnostic tests were performed with more than two results (ROC Curve).
Results: The most representative age group was 66-76 years, with a slight predominance of males. Increased mortality was reported in more advanced stages of sepsis. Lactate was the marker with the highest sensitivity.
Conclusions: Lactate, C-reactive protein, hematocrit and prothrombin time were the most sensitive from the classic biomarkers. Despite having low specificity, they are useful for the management of the septic patient, since they have higher values as the stage of sepsis or the risk of dying are advanced.


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