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2020, Number 1

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Rev Cubana Neurol Neurocir 2020; 10 (1)

P300 event-related potential during sustained attention in Parkinson's disease patients

Báez MMM, Casabona FE, Morales CLM, Pedroso II, Alarcón CC, Alfonso AM

Language: Spanish
References: 23
Page: 1-17
PDF size: 399.80 Kb.


ABSTRACT

Objective: To evaluate the relationship between the P300 event-related potential with visual attention significance and the results of neuropsychological evaluation in patients with Parkinson's disease in Hoehn and Yahr stages II and III.
Methods: A cross-sectional analytical study was carried out evaluating 57 patients with idiopathic Parkinson's disease, who were treated from December 2017 to April 2018 at the International Center for Neurological Restoration, in Havana. P300 was recorded during the execution of a visual sustained attention task. The latency and amplitude of P300 were measured, which was correlated (Spearman's correlation test, p <0.01) with demographic variables, efficiency variables in the sustained attention task and neuropsychological variables. The results of Hoehn and Yahr groups II and III were compared with respect to all the variables studied (Mann Whitney U test, p <0.05).
Results: Significant latency difference was found between groups of P300 component in Pz electrode. It was more prolonged in Hoehn and Yahr group III. Negative correlations were found in group II between P300 latency and the frontal evaluation battery test, and positive correlations between P300 latency and Stroop test. The correlations between the frontal evaluation battery test and P300 amplitude were positive, and between Stroop test and P300 amplitude were negative. Similar results were evident in group III regarding P300 amplitude, which corresponded to worse performance in the neuropsychological evaluation.
Conclusions: A close relationship between P300 event-related potential with visual attention significance and the results of the neuropsychological evaluation in Parkinson's disease patients, in Hoehn and Yahr stages II and III, was verified. P300 potential was an objective examination that reinforced the validity of the neuropsychological evaluation results.


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