Valdespino-Castillo VE, Landa-Mejía J, Maytorena-Córdova G, Ballesteros-Montenegro Y, Zavala-Ramírez G, Valdespino-Gómez V

Language: Spanish
References: 16
Page: 815-819
PDF size: 215.30 Kb.

ABSTRACT

Background: Müllerian abnormalities are between 0.5 and 5% depends on the population in a clinical trial, and endometroid ovarian cancer is 10% of all ovarian cancers.
Clinic case: A 45-year-old patient with chronic abdominal-pelvic pain associated with high concentrations of Ca-125 (94 U). In the extension studies, the radiography reported: uterus didelphys and a solid ovarian tumor. Treatment consisted of resection of the lesion of the right ovary. The histopathology report was: endometrioid carcinoma grade 2 (IC2), moderately differentiated. The adjuvant chemotherapy protocol included 6 cycles of carboplatin and paclitaxel, with good tolerance. Today the patient is disease free and under regular surveillance.
Conclusions: The diagnosis of Müllerian malformations is established by amenorrhea in young patients and failure to achieve a full-term pregnancy in adult women. The association between ovarian malignancy and endometrial hyperplasia in both uterine cavities and gynecological malformations has been very little reported in the literature.

REFERENCES

1. Dietrich JE, et al. Obstructive reproductive tract anomalies. J Pediatr Adolesc Gynecol 2014; 27 (6): 396-402. Doi: 10.1016/j.jpag.2014.09.001

2. The Global Cancer Observatory. Ovary. Globocan 2019. https://gco.iarc.fr/today/data/factsheets/cancers/25- Ovary-fact-sheet.pdf

3. Reid BM, et al. Epidemiology of ovarian cancer: a review TA. Cancer Biol Med. 2017; 14 (1): 9-32. doi: 10.20892/j. issn.2095-3941.2016.0084

4. Prat J. Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features. Virchows Arch 2012; 460 (3): 237-249. doi: 10.1007/s00428-012-1203-5.

5. Jáuregui-Meléndrez RA, et al. Estado actual de la clasificación, diagnóstico y tratamiento de las malformaciones müllerianas. Ginecol Obstet Mex 2013; 81: 34-46. https:// ginecologiayobstetricia.org.mx/secciones/articulos-derevision/ estado-actual-de-la-clasificacion-diagnostico-ytratamiento- de-las-malformaciones-mullerianas/

6. Nahum GG. Uterine anomalies. How common are they, and what is their distribution among subtypes? J Reprod Med 1998; 43 (10): 877-87. http://europepmc.org/article/ med/9800671

7. Kim H, et al.Ovarian dysgerminoma with Müllerian anomaly: a case report. Obstet Gynecol Sci 2020; 63 (1): 98- 101. doi: 10.5468/ogs.2020.63.1.98

8. Bae HS, et al. Cancer of the supernumerary ovary in Mayer Rokitansky- Küster- Hauser Syndrome: A case report. Oncology Letters 2013: 5; 598-600. doi: 10.3892/ol.2012.1073

9. Barik S, et al. Adenocarcinoma of the supernumerary ovary. Int J Gynecol Obstet 1990; 34 (1): 75-77. https:// doi.org/10.1016/0020-7292(91)90543-E

10. Dane C, et al. A single horn endometrial carcinoma of a uterus bicornis unicollis. J Gynecol Oncol 2009; 20 (3): 195-197. doi: 10.3802/jgo.2009.20.3.195

11. American Joint Committee on Cancer. Cancer Staging Manual. 8th Ed. New York: Springer, 2016.

12. Lim YK, et al. Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study. J Gynecol Oncol 2011; 22 (4): 239-243. doi: 10.3802/jgo.2011.22.4.239

13. Gutierrez PL, et al. Tumores triple sincrónicos ginecológicos. Cir y Cir 2016; 84 (1): 69-72. https://doi.org/10.1016/j. circir.2015.06.015

14. Vazquez CF, et al. Adenocarcinoma de endometrio en útero septo: utilidad de la histeroscopia en el diagnóstico. Prog Obstet Ginecol 2006; 49 (7): 398-400. doi: 10.1016/ S0304-5013(06)72625-5

15. Gede BI, et al. Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery. J Turk Ger Gynecol Assoc 2019; 20 (1): 47-54. doi: 10.4274/jtgga. galenos.2018.2018.0119

16. Singh A, et al. Epigenetic biomarkers in the management of ovarian cancer: Current prospectives. Front Cell Dev Biol 2019; 7: 182. doi: 10.3389/fcell.2019.00182