2019, Number 3
<< Back Next >>
Rev Cuba Endoc 2019; 30 (3)
Mycoplasma hominis and Ureaplasma spp. in women attending to infertility consultations
Rodríguez PBV, Reyes RH, Vázquez NJC, Cabrera GM, González HO, Menéndez CAM
Language: Spanish
References: 30
Page:
PDF size: 0. Kb.
ABSTRACT
Introduction: Infections caused by Mycoplasmas and Ureaplasmas may result in faults in the reproduction process and can be linked to female infertility.
Objective: To determine the frequency of infection by Mycoplasma hominis and Ureaplasma spp. in women who attend to infertility consultations and if these are associated with a history of sexually transmitted infections and pelvic inflammatory disease, gynaecological procedures and symptoms of infections.
Methods: A descriptive cross-sectional study was conducted to evaluate samples of endocervical swabs of 175 women between the ages of 20 to 45 years, from the Infertility consultation of the National Institute of Endocrinology, during June 2016 to January 2017. For the detection of urogenital mycoplasmas it was used the reagents kit Myco Well D-One. There were taken into account the ethical aspects and it was used the chi-square test to assess the statistical significance of the possible associations.
Results: Of the 175 evaluated samples, 102 (58.1 %) showed the presence of infections, 65 of them corresponded to Ureaplasma spp (37.1%), 11 to Mycoplasma hominis (6.2 %), and 26 associations of Mycoplasma hominis and Ureaplasma spp (14.8 %). It was identified association between the detected infections and the presence of a history of sexually transmitted infections and pelvic inflammatory disease, but not with the gynaecological procedures and the symptoms of infections.
Conclusions: The total frequency of infection was relatively high and the most prevalent specie was the Ureaplasma spp. The detected infections were associated with some of the factors studied.
REFERENCES
Tsevat D, Wiesenfeld H, Parks C, Peipert J. Sexually transmitted diseases and infertility. Am J Obstet Gynecol. 2017;216:1-9.
Chen M, Fabrizi S. Challenges to the management of curable sexually transmitted infections. Infect Dis. 2015;15:337-42.
Leli C, Mencacci A, Latino M, Clerici P, Rassu M, Perito S, et al. Prevalence of cervical colonization by Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR: An Italian observational multicentre study. J Microbiol Immunol Infect. 2018;51:220-5.
Munoz J, Goje O. Mycoplasma genitalium: An Emerging Sexually Transmit Infect Scientif.2016; 2016;2016:7537318. doi: 10.1155/2016/7537318. Epub. 2016 Feb 29. Review. PMID: 27034904.
Marovt M, Kese D, Kotar T, Kmet N, Miljkovic J, Soba B, et al. Ureaplasma parvum and Ureaplasma urealyticum detected with the same frequency among women with and without symptoms of urogenital tract infection. Infect Dis. 2015;14:237-45.
Arnold M. Micoplasmas urogenitales como causa de infertilidad femenina. Hospital Ginecobstétrico Provincial de Matanzas. 2014-2015. Rev Med Electrón. [Internet]. 2016 [citado : 24/06/2017];38(3). Disponible en: http://bvs.sld.cu/revistas/end/vol24_1_13/end05113.htm.
Hernández I, Aragón C, Aldama P, Jiménez J. Prevalencia de infecciones (Chlamydia, Ureaplasma y Mycoplasma) en pacientes con factor tuboperitoneal alterado. Rev Ginecol Obstet Mex. 2016;84:14-8.
Sleha R, Bostikova V, Hampl R, Salavec M, Halada P, Stepan M, et al. Prevalence of Mycoplasma hominis and Ureaplasma urealyticum in women undergoing an initial infertility evaluation. Epidemiol Microbiol Imunol. 2016;65:232-7.
Kokkayil P, Dhawan B. Ureaplasma: Current perspectives. Indian J Med Microbiol. 2015;33:205-14.
Cordoví L, Castillo F, Cordero M, Sosa Y. Influencia de la sepsis vaginal endógena sobre la calidad del moco cervical en mujeres infértiles. Medisan. 2014;18:1254-9.
Álvarez A, Rivero L, Martínez J, Álvarez V. La infección en el factor cervical y su relación con la infertilidad. Rev Cub Obst Ginecol. [Internet]. 2004, vol.30, n.2. ISSN 1561-3062.
Tandon D, Munne K, Chauhan S, Patil A. An update on prevalence, diagnosis, treatment and emerging issues of genital mycoplasma infection in Indian women: A narrative review. Indian J Dermatol Venereol Leprol. 2019;85:441-7.
Ortíz C, Hechavarría C, Ley M, Álvarez G, Hernández Y. Estudio de Chlamydia trachomatis, Ureaplasma urealyticum y Mycoplasma hominis en pacientes infértiles y abortadoras habituales. Rev Cub Obstet Ginecol. 2010;36:573-84.
Rojas L, Rodríguez M, Sarría C, Palma S, Sariego I, Fraga J. Frecuencia de infección por Trichomonas vaginales en parejas con trastorno de la fertilidad. Rev Cub Med Trop. 2002;54:85-90.
Duque M. Aislamiento e identificación de Ureaplasma spp y Mycoplasma hominis en muestras endocervicales de pacientes infértiles [Tesis]. La Habana: Instituto Superior Ciencias Médicas, Facultad Comandante Manuel Fajardo; 2008.
Rodríguez N, Rivera A, Fernández C, Mondeja B, Echevarría E, Verdasquera D. Detection of Urogenital Mycoplasmas in Cuban Women with Infertility Antecedents. J of Pure and Applied Microbial. 2014;8:171-5.
Ramírez Y, Zayas A, Mesa I, Rodríguez L, Ramos M, Bell Y. Infección por Mycoplasmas en mujeres infértiles. Revista Cubana de Obstetricia y Ginecología [Internet]. 2019 [citado : 27/08/2019];44(4):[aprox. 0 p.]. Disponible en: http://www.revginecobstetricia.sld.cu/index.php/gin/article/view/391.
Mico well D-one. System for detection, count, and susceptibility testing of urogenital mycoplasmas and ureaplasmas. Liofichen Bacteriology products. [Internet]. Italia; 2008. Liofilchen bacteriology products; 2008. Disponible en www. Liofilchen.net.
Sexually transmitted infections (STIs): the importance of a renewed commitment to STI prevention and control in achieving global sexual and reproductive health. WHO, Geneva; 2013.
Kundsin R. Mycoplasmas in genitourinary tract infection and reproductive failure. In Progress in Gynecology, S. H. Sturgis and M. L. Taymor, Eds., Grune & Stratton, New York, NY, USA; 1970. View at Google Scholar.
Seifoleslami M, Safari A, Khayyat K. Prevalence of Ureaplasma urealyticum and Mycoplasma hominis in High Vaginal Swab Samples of Infertile Females. Iran Red Crescent Med J. 2015;17:105-12.
Miron N, Socolov D, Mareş M, Anton G, Nastasa V, Moraru R, et al. Bacteriological agents which play a role in the development of infertility. Acta Microbiol Immunol Hung. 2013;60:41-53.
Mousavi A, Farhadifar F, Mirnejad R, Ramazanzadeh R. Detection of genital mycoplasma infections among infertile females by multiplex PCR. Iran J Microbiol. 2014;6:398-403.
Imudia A, Detti L, Puscheck E, Yelian F, Diamond M. The prevalence of Ureaplasma urealyticum, Mycoplasma hominis, Chlamydia trachomatis and Neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation. J Assist Reprod Genet. 2008;25:43-6.
Michou I, Constantoulakis P, Makarounis K, Georgoulias G, Kapetanios V, Tsilivakos V. Molecular investigation of menstrual tissue for the presence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis collected by women with a history of infertility. J Obstet Gynecol Res. 2014;40:237-42.
Adesola T, Oluwasola T, Ajani M, Bakare R. The prevalence of and risk factors for mycoplasma genitalium infection among infertile women in Ibadan: A cross-sectional study. Int J Reprod Biomed. 2017;15:613-18.
Tamarelle J, Thiebaut A, Sabin B, Bebear C, Judlin P, Fauconnier A, et al. Early screening for Chlamydia trachomatis in young women for primary prevention of pelvic inflammatory disease: study protocol for a randomised controlled trial. Trials. 2017;18:534-42.
Liu M, Zeng G, Zhang L, Liu Z, Li S. An epidemiological survey on reproductive tract infections and the investigation on syndromic approach on vaginal discharge. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23:422-6.
Wiesenfeld H, Manhart L. Mycoplasma genitalium in Women: Current Knowledge and Research Priorities for This Recently Emerged Pathogen. J Infect Dis. 2017;216:389-95.
Zanotta N, Campisciano G, Morassut S, Castro Silva E, Luksa V, Zito G, et al. Emerging role for Ureaplasma parvum serovar 3: Active infection in women with silent high-risk human papillomavirus and in women with idiopathic infertility. J Cell Physiol. 2019;234:905-11.