Izquierdo-Torres E, Lozano-Arriaga D, Hernández-Oliveras A, Zarain-Herzberg Á

Language: Spanish
References: 54
Page: 40-51
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ABSTRACT

The calcium ion (Ca²⁺) is a second messenger, which controls a wide variety of cellular processes, among which are those that are altered in cancer cells. One of the proteins involved in Ca²⁺ homeostasis is SERCA ATPase, which pumps it from the cytosol to the lumen of the endoplasmic reticulum to restore the steady state. SERCA genes (ATP2A1-3) encode for different functional isoforms of the protein. The expression and/or function of SERCA is altered in various types of cancer, such as gastric, colon, breast, lung, thyroid, liver, oral, and prostate cancer, among others. However, part of the mechanisms that control SERCA expression in both physiological and pathological conditions are unknown, as well as its role in carcinogenesis. Understanding the role of SERCA in this process could lead us to develop better therapeutic and prognostic strategies, to improve the treatment of patients with different types of cancer.

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