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2020, Número 2

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Rev Educ Bioquimica 2020; 39 (2)


Las bombas de calcio serca: su papel en la patogénesis tumoral e implicaciones clínicas

Izquierdo-Torres E, Lozano-Arriaga D, Hernández-Oliveras A, Zarain-Herzberg Á

Idioma: Español
Referencias bibliográficas: 54
Paginas: 40-51
Archivo PDF: 625.36 Kb.


RESUMEN

El ion calcio (Ca2+) es un segundo mensajero que controla una gran variedad de procesos celulares, entre los cuales destacan aquellos que están alterados en células cancerosas. Dentro de las proteínas involucradas en la homeostasis de Ca2+ se encuentran las ATPasas SERCA, que lo bombean desde el citosol hacia el lumen del retículo endoplásmico para restaurar el estado de reposo. Los genes SERCA (ATP2A1- 3) codifican para distintas isoformas funcionales de la proteína. La expresión y/o función de SERCA se encuentra alterada en diversos tipos de cáncer, entre los que se encuentran gástrico, colon, mama, pulmón, tiroides, hígado, oral y próstata, entre otros. Sin embargo, aún se desconocen parte de los mecanismos que controlan la expresión de SERCA tanto en condiciones fisiológicas como patológicas, así como su papel en la carcinogénesis. Entender el rol de SERCA en este proceso podría llevarnos a desarrollar mejores estrategias terapéuticas y de pronóstico para mejorar el tratamiento de los distintos tipos de cáncer.


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